Article ; Online: French multicentre observational study on SARS-CoV-2 infections intensive care initial management: the FRENCH CORONA study.
Anaesthesia, critical care & pain medicine
2021 Volume 40, Issue 4, Page(s) 100931
Abstract: ... Prospective multicentre, cohort study conducted in 29 French ICUs. Baseline characteristics, comorbidities ... Aim: Describing acute respiratory distress syndrome patterns, therapeutics management, and ... to optimise hospital and ICU resources and provide the appropriate intensity level of care. ...
| Abstract | Aim: Describing acute respiratory distress syndrome patterns, therapeutics management, and outcomes of ICU COVID-19 patients and indentifying risk factors of 28-day mortality. Methods: Prospective multicentre, cohort study conducted in 29 French ICUs. Baseline characteristics, comorbidities, adjunctive therapies, ventilatory support at ICU admission and survival data were collected. Results: From March to July 2020, 966 patients were enrolled with a median age of 66 (interquartile range 58-73) years and a median SAPS II of 37 (29-48). During the first 24 h of ICU admission, COVID-19 patients received one of the following respiratory supports: mechanical ventilation for 559 (58%), standard oxygen therapy for 228 (24%) and high-flow nasal cannula (HFNC) for 179 (19%) patients. Overall, 721 (75%) patients were mechanically ventilated during their ICU stay. Prone positioning and neuromuscular blocking agents were used in 494 (51%) and 460 (48%) patients, respectively. Bacterial co-infections and ventilator-associated pneumonia were diagnosed in 79 (3%) and 411 (43%) patients, respectively. The overall 28-day mortality was 18%. Age, pre-existing comorbidities, severity of respiratory failure and the absence of antiviral therapy on admission were identified as independent predictors of 28-day outcome. Conclusion: Severity of hypoxaemia on admission, older age (> 70 years), cardiovascular and renal comorbidities were associated with worse outcome in COVID-19 patients. Antiviral treatment on admission was identified as a protective factor for 28-day mortality. Ascertaining the outcomes of critically ill COVID-19 patients is crucial to optimise hospital and ICU resources and provide the appropriate intensity level of care. |
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| MeSH term(s) | Aged ; COVID-19 ; Cohort Studies ; Critical Care ; Humans ; Intensive Care Units ; Middle Aged ; Prospective Studies ; Respiration, Artificial ; SARS-CoV-2 |
| Language | English |
| Publishing date | 2021-07-10 |
| Publishing country | France |
| Document type | Journal Article ; Multicenter Study ; Observational Study |
| ISSN | 2352-5568 |
| ISSN (online) | 2352-5568 |
| DOI | 10.1016/j.accpm.2021.100931 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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