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  1. Article ; Online: TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.

    Romagnani, Andrea / Vettore, Valentina / Rezzonico-Jost, Tanja / Hampe, Sarah / Rottoli, Elsa / Nadolni, Wiebke / Perotti, Michela / Meier, Melanie A / Hermanns, Constanze / Geiger, Sheila / Wennemuth, Gunther / Recordati, Camilla / Matsushita, Masayuki / Muehlich, Susanne / Proietti, Michele / Chubanov, Vladimir / Gudermann, Thomas / Grassi, Fabio / Zierler, Susanna

    Nature communications

    2017  Volume 8, Issue 1, Page(s) 1917

    Abstract: ... a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 ... The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and ... kinase-dead mutant (Trpm7 ...

    Abstract The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7
    MeSH term(s) Animals ; Antigens, CD/immunology ; Cell Differentiation/genetics ; Genes, MHC Class II/genetics ; Genes, MHC Class II/immunology ; Graft vs Host Disease/genetics ; Graft vs Host Disease/immunology ; Integrin alpha Chains/immunology ; Intestines/immunology ; Lymphopoiesis/genetics ; Mice ; Mutation ; Smad2 Protein/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; TRPM Cation Channels/genetics ; TRPM Cation Channels/immunology ; Th17 Cells/cytology ; Th17 Cells/immunology ; Transforming Growth Factor beta/immunology
    Chemical Substances Antigens, CD ; Integrin alpha Chains ; Smad2 Protein ; Smad2 protein, mouse ; TRPM Cation Channels ; Transforming Growth Factor beta ; alpha E integrins ; Trpm7 protein, mouse (EC 2.7.1.-)
    Language English
    Publishing date 2017-12-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2041-1723
    ISSN (online) 2041-1723
    DOI 10.1038/s41467-017-01960-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut

    Andrea Romagnani / Valentina Vettore / Tanja Rezzonico-Jost / Sarah Hampe / Elsa Rottoli / Wiebke Nadolni / Michela Perotti / Melanie A. Meier / Constanze Hermanns / Sheila Geiger / Gunther Wennemuth / Camilla Recordati / Masayuki Matsushita / Susanne Muehlich / Michele Proietti / Vladimir Chubanov / Thomas Gudermann / Fabio Grassi / Susanna Zierler

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 14

    Abstract: ... protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell ... alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells ... Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and ...

    Abstract Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells
    Keywords Science ; Q
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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