Article ; Online: Extracorporeal Blood Purification and Organ Support in the Critically Ill Patient during COVID-19 Pandemic: Expert Review and Recommendation.
2020 Volume 50, Issue 1, Page(s) 17–27
Abstract: ... for sequential extracorporeal therapies designed to remove inflammatory mediators and support different organ ... Critically ill COVID-19 patients are generally admitted to the ICU for respiratory insufficiency ... could represent an option to prevent organ failure and improve survival. The enormous demand in care for COVID-19 ...
| Abstract | Critically ill COVID-19 patients are generally admitted to the ICU for respiratory insufficiency which can evolve into a multiple-organ dysfunction syndrome requiring extracorporeal organ support. Ongoing advances in technology and science and progress in information technology support the development of integrated multi-organ support platforms for personalized treatment according to the changing needs of the patient. Based on pathophysiological derangements observed in COVID-19 patients, a rationale emerges for sequential extracorporeal therapies designed to remove inflammatory mediators and support different organ systems. In the absence of vaccines or direct therapy for COVID-19, extracorporeal therapies could represent an option to prevent organ failure and improve survival. The enormous demand in care for COVID-19 patients requires an immediate response from the scientific community. Thus, a detailed review of the available technology is provided by experts followed by a series of recommendation based on current experience and opinions, while waiting for generation of robust evidence from trials. |
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| MeSH term(s) | COVID-19/blood ; COVID-19/complications ; COVID-19/therapy ; Continuous Renal Replacement Therapy/instrumentation ; Continuous Renal Replacement Therapy/methods ; Critical Illness/epidemiology ; Critical Illness/therapy ; Cytokines/blood ; Cytokines/isolation & purification ; Equipment Design ; Extracorporeal Membrane Oxygenation/instrumentation ; Extracorporeal Membrane Oxygenation/methods ; Hemoperfusion/instrumentation ; Hemoperfusion/methods ; Humans ; Multiple Organ Failure/blood ; Multiple Organ Failure/etiology ; Multiple Organ Failure/therapy |
| Chemical Substances | Cytokines |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-26 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 605548-5 |
| ISSN | 1421-9735 ; 0253-5068 |
| ISSN (online) | 1421-9735 |
| ISSN | 0253-5068 |
| DOI | 10.1159/000508125 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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