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Article ; Online: Neutrophils: Their Role in Innate and Adaptive Immunity 2017.

Rosales, Carlos / Lowell, Clifford A / Schnoor, Michael / Uribe-Querol, Eileen

2017 Volume 2017, Page(s) 9748345

MeSH term(s)	Adaptive Immunity ; Animals ; Extracellular Traps/immunology ; Humans ; Immune Evasion ; Immunity, Innate ; Neutrophils/immunology ; Receptors, Interleukin-8B/metabolism ; Signal Transduction ; Staphylococcal Infections/immunology ; Staphylococcus aureus/immunology ; Syk Kinase/metabolism
Chemical Substances	Receptors, Interleukin-8B ; Syk Kinase (EC 2.7.10.2)
Language	English
Publishing date	2017-11-07
Publishing country	Egypt
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-8861
ISSN (online)	2314-7156
ISSN	2314-8861
DOI	10.1155/2017/9748345
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Article ; Online: Neutrophils: Their Role in Innate and Adaptive Immunity.

Rosales, Carlos / Demaurex, Nicolas / Lowell, Clifford A / Uribe-Querol, Eileen

Journal of immunology research

2016 Volume 2016, Page(s) 1469780

MeSH term(s)	Adaptive Immunity ; Humans ; Immunity, Innate ; Neutrophils/immunology
Language	English
Publishing date	2016
Publishing country	Egypt
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-8861
ISSN (online)	2314-7156
ISSN	2314-8861
DOI	10.1155/2016/1469780
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Article ; Online: Neutrophils

Petty Howard R / Jiang Kaiyu / Jarvis James N / Centola Michael

Pediatric Rheumatology, Vol 5, Iss 1, p

the forgotten cell in JIA disease pathogenesis

2007 Volume 13

Abstract: ... to this family of diseases have suggested complex interactions between innate and adaptive immunity that underlie ... regulatory functions that link neutrophils to adaptive immune responses, and discuss future areas ... JIA. In particular, new data suggest an important role for neutrophils in JIA pathogenesis ...

Abstract	Abstract Juvenile idiopathic arthritis (JIA) has long been assumed to be an autoimmune disease, triggered by aberrant recognition of "self" antigens by T-cells. However, systems biology approaches to this family of diseases have suggested complex interactions between innate and adaptive immunity that underlie JIA. In particular, new data suggest an important role for neutrophils in JIA pathogenesis. In this short review, we will discuss the new data that support a role for neutrophils in JIA, discuss regulatory functions that link neutrophils to adaptive immune responses, and discuss future areas of investigation. Above all else, we invite the reader to re-consider the use of the term "autoimmunity" as applied to the family of illnesses we collectively call JIA.
Keywords	Diseases of the musculoskeletal system ; RC925-935 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Pediatrics ; RJ1-570 ; DOAJ:Pediatrics
Language	English
Publishing date	2007-06-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neutrophils: from IBD to the gut microbiota.

Danne, Camille / Skerniskyte, Jurate / Marteyn, Benoit / Sokol, Harry

Nature reviews. Gastroenterology & hepatology

2023 Volume 21, Issue 3, Page(s) 184–197

Abstract: ... that results from dysfunction in innate and/or adaptive immune responses. Impaired innate immunity, which leads ... players in innate immunity in IBD, but their roles have been neglected compared ... roles played by neutrophils in host-microbiota interactions, both at steady state and in inflammatory ...

Abstract	Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that results from dysfunction in innate and/or adaptive immune responses. Impaired innate immunity, which leads to lack of control of an altered intestinal microbiota and to activation of the adaptive immune system, promotes a secondary inflammatory response that is responsible for tissue damage. Neutrophils are key players in innate immunity in IBD, but their roles have been neglected compared with those of other immune cells. The latest studies on neutrophils in IBD have revealed unexpected complexities, with heterogeneous populations and dual functions, both deleterious and protective, for the host. In parallel, interconnections between disease development, intestinal microbiota and neutrophils have been highlighted. Numerous IBD susceptibility genes (such as NOD2, NCF4, LRRK2, CARD9) are involved in neutrophil functions related to defence against microorganisms. Moreover, severe monogenic diseases involving dysfunctional neutrophils, including chronic granulomatous disease, are characterized by intestinal inflammation that mimics IBD and by alterations in the intestinal microbiota. This observation demonstrates the dialogue between neutrophils, gut inflammation and the microbiota. Neutrophils affect microbiota composition and function in several ways. In return, microbial factors, including metabolites, regulate neutrophil production and function directly and indirectly. It is crucial to further investigate the diverse roles played by neutrophils in host-microbiota interactions, both at steady state and in inflammatory conditions, to develop new IBD therapies. In this Review, we discuss the roles of neutrophils in IBD, in light of emerging evidence proving strong interconnections between neutrophils and the gut microbiota, especially in an inflammatory context.
MeSH term(s)	Humans ; Gastrointestinal Microbiome ; Neutrophils ; Microbiota ; Inflammatory Bowel Diseases ; Inflammation
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2493722-8
ISSN	1759-5053 ; 1759-5045
ISSN (online)	1759-5053
ISSN	1759-5045
DOI	10.1038/s41575-023-00871-3
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Zs.A 6020: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Neutrophils as Sentinel Cells of the Immune System: A Role of the MPO-halide-system in Innate and Adaptive Immunity.

Marcinkiewicz, Janusz / Walczewska, Maria

Current medicinal chemistry

2019 Volume 27, Issue 17, Page(s) 2840–2851

Abstract: ... of adaptive immunity. Thereafter, we developed our theory concerning the role of neutrophils as the cells which link ... innate and adaptive immunity. We proposed that protein modification by HOCl may act ... microbial and anti-inflammatory properties. In this review, the role of HOCl, taurine and TauCl in innate ...

Abstract	For decades, neutrophils were generally regarded as the cells of innate immunity with proinflammatory and phagocytic properties involved in a dual activity, beneficial (antimicrobial) and detrimental (tissue damage). Importantly, until the discovery of toll-like receptors (TLRs), a role of neutrophils in adaptive immunity was limited to the effector stage of humoral response and phagocytosis of opsonized antigens. Moreover, in common opinion, neutrophils, as well as the entire innate immune system, were not functionally associated with adaptive immunity. At the time we demonstrated protein chlorination by HOCl, the major product of neutrophil MPO-halide system enhances protein immunogenicity. Based on this discovery, we proposed, as the first, a new role for neutrophils as APC-accessory cells involved in the induction stage of adaptive immunity. Thereafter, we developed our theory concerning the role of neutrophils as the cells which link innate and adaptive immunity. We proposed that protein modification by HOCl may act as a neutrophildependent molecular tagging system, by which sentinel dendritic cells can faster recognise pathogen- derived antigens. Contemporaneously, it was demonstrated that taurine, the most abundant free amino acid in neutrophil cytosol and the major scavenger of HOCl, is a part of the oxidantantioxidant network and is responsible for the regulation and termination of acute inflammation. Moreover, it has been described, that taurine chloramine (TauCl), the physiological products of the reaction of HOCl with taurine, show anti-microbial and anti-inflammatory properties. In this review, the role of HOCl, taurine and TauCl in innate and adaptive immunity will be discussed.
MeSH term(s)	Adaptive Immunity ; Humans ; Hypochlorous Acid ; Immunity, Innate ; Inflammation ; Inflammation Mediators ; Neutrophils ; Peroxidase
Chemical Substances	Inflammation Mediators ; Hypochlorous Acid (712K4CDC10) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2019-08-18
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867326666190819123300
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Zs.A 4432: Show issues

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Article ; Online: Neutrophils at the Crossroads: Unraveling the Multifaceted Role in the Tumor Microenvironment.

Awasthi, Deepika / Sarode, Aditya

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: ... system. While these innate functions enable neutrophils to interact with adaptive immune cells such as T, B, and NK cells ... immune system, neutrophils play a pivotal and abundant role, constituting approximately ∼70% of all peripheral ... Consequently, neutrophils are emerging as crucial regulators in both pro- and anti-tumor immunity ...

Abstract	Over the past decade, research has prominently established neutrophils as key contributors to the intricate landscape of tumor immune biology. As polymorphonuclear granulocytes within the innate immune system, neutrophils play a pivotal and abundant role, constituting approximately ∼70% of all peripheral leukocytes in humans and ∼10-20% in mice. This substantial presence positions them as the frontline defense against potential threats. Equipped with a diverse array of mechanisms, including reactive oxygen species (ROS) generation, degranulation, phagocytosis, and the formation of neutrophil extracellular traps (NETs), neutrophils undeniably serve as indispensable components of the innate immune system. While these innate functions enable neutrophils to interact with adaptive immune cells such as T, B, and NK cells, influencing their functions, they also engage in dynamic interactions with rapidly dividing tumor cells. Consequently, neutrophils are emerging as crucial regulators in both pro- and anti-tumor immunity. This comprehensive review delves into recent research to illuminate the multifaceted roles of neutrophils. It explores their diverse functions within the tumor microenvironment, shedding light on their heterogeneity and their impact on tumor recruitment, progression, and modulation. Additionally, the review underscores their potential anti-tumoral capabilities. Finally, it provides valuable insights into clinical therapies targeting neutrophils, presenting a promising approach to leveraging innate immunity for enhanced cancer treatment.
MeSH term(s)	Humans ; Animals ; Mice ; Neutrophils ; Tumor Microenvironment ; Immunity, Innate ; Extracellular Traps ; Phagocytosis
Language	English
Publishing date	2024-03-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052929
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Article ; Online: Neutrophils, functions beyond host defense.

Wang, Jin / Wang, Jing

Cellular immunology

2022 Volume 379, Page(s) 104579

Abstract: ... of neutrophils beyond a phagocyte. Furthermore, neutrophils are known to actively communicate with innate and ... heterogeneity and function under disease and homeostasis settings has revealed many unexpected roles ... plasticity of neutrophils under homeostatic and inflammatory conditions. The exploration of neutrophil ...

Abstract	Neutrophils are the most abundant, ephemeral cell type in human blood. As the first line of defense in the host immune system, neutrophils mature in the bone marrow after undergoing multiple stages of development and then are released into the peripheral blood and conduct a surveillance function. Recent advances in cutting-edge techniques such as single-cell sequencing have uncovered the complexity and plasticity of neutrophils under homeostatic and inflammatory conditions. The exploration of neutrophil heterogeneity and function under disease and homeostasis settings has revealed many unexpected roles of neutrophils beyond a phagocyte. Furthermore, neutrophils are known to actively communicate with innate and adaptive immunocytes via direct or indirect interactions, allowing the modulation of various immune cells. In this review, we will discuss the versatile identities of neutrophils that have been discovered in recent decades, as well as the interplay between neutrophils and other cells.
MeSH term(s)	Homeostasis ; Humans ; Neutrophils
Language	English
Publishing date	2022-07-19
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2022.104579
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Zs.A 417: Show issues

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Article ; Online: Neutrophils in respiratory viral infections.

Johansson, Cecilia / Kirsebom, Freja C M

Mucosal immunology

2021 Volume 14, Issue 4, Page(s) 815–827

Abstract: ... who are immunocompromised, and in the elderly. Neutrophils, an important innate immune cell, infiltrate ... in protection from numerous bacterial and fungal infections is well established. However, the role ... inherently less clear how neutrophils can contribute to host immunity to viruses without causing ...

Abstract	Viral respiratory infections are a common cause of severe disease, especially in infants, people who are immunocompromised, and in the elderly. Neutrophils, an important innate immune cell, infiltrate the lungs rapidly after an inflammatory insult. The most well-characterized effector mechanisms by which neutrophils contribute to host defense are largely extracellular and the involvement of neutrophils in protection from numerous bacterial and fungal infections is well established. However, the role of neutrophils in responses to viruses, which replicate intracellularly, has been less studied. It remains unclear whether and, by which underlying immunological mechanisms, neutrophils contribute to viral control or confer protection against an intracellular pathogen. Furthermore, neutrophils need to be tightly regulated to avoid bystander damage to host tissues. This is especially relevant in the lung where damage to delicate alveolar structures can compromise gas exchange with life-threatening consequences. It is inherently less clear how neutrophils can contribute to host immunity to viruses without causing immunopathology and/or exacerbating disease severity. In this review, we summarize and discuss the current understanding of how neutrophils in the lung direct immune responses to viruses, control viral replication and spread, and cause pathology during respiratory viral infections.
MeSH term(s)	Adaptive Immunity ; Animals ; Biomarkers ; Cell Communication ; Coinfection ; Cytokines/metabolism ; Disease Resistance/genetics ; Disease Resistance/immunology ; Disease Susceptibility ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Neutrophil Infiltration/genetics ; Neutrophil Infiltration/immunology ; Neutrophils/immunology ; Neutrophils/metabolism ; Respirovirus/physiology ; Respirovirus Infections/etiology ; Respirovirus Infections/metabolism ; Respirovirus Infections/pathology ; Severity of Illness Index ; Virus Replication
Chemical Substances	Biomarkers ; Cytokines
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1038/s41385-021-00397-4
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Zs.A 6796: Show issues

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Article ; Online: Neutrophils in Mycobacterium tuberculosis

Cheldon Ann Alcantara / Ira Glassman / Kevin H. Nguyen / Arpitha Parthasarathy / Vishwanath Venketaraman

Vaccines, Vol 11, Iss 631, p

2023 Volume 631

Abstract: ... on the efficacy of the BCG vaccine. Critical within their role in the innate immune response, neutrophils serve ... to highlight and summarize the role of neutrophils during an M. tb infection. Furthermore, the authors ... within developing countries. The BCG vaccine to promote immunity against M. tb is widely used in developing countries and only ...

Abstract	Mycobacterium tuberculosis ( M. tb ) continues to be a leading cause of mortality within developing countries. The BCG vaccine to promote immunity against M. tb is widely used in developing countries and only in specific circumstances within the United States. However, current the literature reports equivocal data on the efficacy of the BCG vaccine. Critical within their role in the innate immune response, neutrophils serve as one of the first responders to infectious pathogens such as M. tb . Neutrophils promote effective clearance of M. tb through processes such as phagocytosis and the secretion of destructive granules. During the adaptative immune response, neutrophils modulate communication with lymphocytes to promote a strong pro-inflammatory response and to mediate the containment M. tb through the production of granulomas. In this review, we aim to highlight and summarize the role of neutrophils during an M. tb infection. Furthermore, the authors emphasize the need for more studies to be conducted on effective vaccination against M. tb .
Keywords	neutrophils ; tuberculosis ; infection ; Mycobacterium tuberculosis ; immune system ; Medicine ; R
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Importance of Neutrophils in Osteoarthritis

Yeganeh Mehrani / Rasool Rahimi Junqani / Solmaz Morovati / Hossein Mehrani / Negar Karimi / Samaneh Ghasemi

Immuno, Vol 3, Iss 17, Pp 250-

Current Concepts and Therapeutic Perspectives

2023 Volume 272

Abstract: ... specialized functions contributing to innate and adaptive immune functions. Although neutrophils produce ... disability. Different innate immune components, including macrophages, T cells, and neutrophils, participate ... biology, their role in inflammation and its association with OA, and possible therapeutic approaches ...

Abstract	Osteoarthritis (OA) is the most common degenerative joint disease that causes chronic pain and disability. Different innate immune components, including macrophages, T cells, and neutrophils, participate in OA pathophysiology. Neutrophils are the most abundant circulating leukocytes with multiple specialized functions contributing to innate and adaptive immune functions. Although neutrophils produce proinflammatory cytokines and chemokines, reactive oxygen species (ROS), matrix-degrading enzymes, and neutrophil extracellular traps (NET) that promote joint degradation as the first recruit cells in an inflamed joint, these cells also play an important role in joint repair by regulating the immune response, releasing anti-inflammatory factors, and activating certain protective genes. In this review, various aspects of neutrophil biology, their role in inflammation and its association with OA, and possible therapeutic approaches to target neutrophils for the treatment of OA are described. Since neutrophils play a complex role in the pathophysiology of osteoarthritis, contributing to joint degradation as well as joint repair, targeting these cells is likely to pave the way for a potential therapeutic approach for the management of OA. Future studies are needed to investigate the use of targeted therapies to modulate neutrophil function and identify their subpopulations that are associated with osteoarthritis progression or response to treatment.
Keywords	osteoarthritis ; neutrophil ; innate immunity ; NET ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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