Article ; Online: DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2017 Volume 372, Issue 1731
Abstract: ... CHD-type chromatin remodellers alter chromatin structure during the signalling and repair of DSBs and ... of the themed issue 'Chromatin modifiers and remodellers in DNA repair and signalling'. ... Proper signalling and repair of DNA double-strand breaks (DSB) is critical to prevent ...
| Abstract | Proper signalling and repair of DNA double-strand breaks (DSB) is critical to prevent genome instability and diseases such as cancer. The packaging of DNA into chromatin, however, has evolved as a mere obstacle to these DSB responses. Posttranslational modifications and ATP-dependent chromatin remodelling help to overcome this barrier by modulating nucleosome structures and allow signalling and repair machineries access to DSBs in chromatin. Here we recap our current knowledge on how ATP-dependent SMARCA- and CHD-type chromatin remodellers alter chromatin structure during the signalling and repair of DSBs and discuss how their dysfunction impacts genome stability and human disease.This article is part of the themed issue 'Chromatin modifiers and remodellers in DNA repair and signalling'. |
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| MeSH term(s) | Animals ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/metabolism ; DNA Breaks, Double-Stranded ; DNA Helicases/metabolism ; DNA Repair ; DNA-Binding Proteins/metabolism ; Humans ; Transcription Factors/metabolism | |||||
| Chemical Substances | Chromosomal Proteins, Non-Histone ; DNA-Binding Proteins ; Transcription Factors ; DNA Helicases (EC 3.6.4.-) | |||||
| Language | English | |||||
| Publishing date | 2017-08-25 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 208382-6 | |||||
| ISSN | 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436 | |||||
| ISSN (online) | 1471-2970 | |||||
| ISSN | 0080-4622 ; 0264-3839 ; 0962-8436 | |||||
| DOI | 10.1098/rstb.2016.0285 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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