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  1. TI=Combined therapy for pyoderma gangrenosum
  2. AU="Bisi Bright"

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  1. Artikel: Combined therapy for pyoderma gangrenosum.

    Rozin, A P / Balbir-Gurman, A / Gilead, L / Slodownik, D

    Annals of the rheumatic diseases

    2004  Band 63, Heft 7, Seite(n) 888–889

    Mesh-Begriff(e) Aged ; Cyclophosphamide/therapeutic use ; Cyclosporine/therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Leg Ulcer/drug therapy ; Prednisolone/therapeutic use ; Pyoderma Gangrenosum/drug therapy
    Chemische Substanzen Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Cyclophosphamide (8N3DW7272P) ; Prednisolone (9PHQ9Y1OLM)
    Sprache Englisch
    Erscheinungsdatum 2004-07
    Erscheinungsland England
    Dokumenttyp Case Reports ; Letter ; Review
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard.2003.016824
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Pyoderma gangrenosum successfully treated with split-thickness skin grafting in combination with negative pressure wound therapy: A case report.

    Saito, Naoya / Sagara, Chihiro / Terada, Akari / Akasaka, Eijiro / Nakano, Hajime / Nakajima, Koji / Sawamura, Daisuke

    The Journal of dermatology

    2023  Band 51, Heft 5, Seite(n) e156–e157

    Mesh-Begriff(e) Humans ; Pyoderma Gangrenosum/therapy ; Pyoderma Gangrenosum/surgery ; Negative-Pressure Wound Therapy/methods ; Skin Transplantation/methods ; Female ; Treatment Outcome ; Male ; Combined Modality Therapy/methods ; Middle Aged ; Wound Healing
    Sprache Englisch
    Erscheinungsdatum 2023-11-27
    Erscheinungsland England
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17048
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Combination immunosuppressant therapy for rapidly progressive pyoderma gangrenosum in a child.

    Kawabe, Shinji / Iwata, Naomi / Nishida, Emi / Kohagura, Toaki / Abe, Naoki / Nakaseko, Haruna / Morita, Akimichi

    Modern rheumatology case reports

    2020  Band 5, Heft 1, Seite(n) 137–140

    Abstract: ... right fifth toe, and multiple large deep-seated ulcerations. She was diagnosed with pyoderma gangrenosum ... may be a treatment option for patients with severe, rapidly progressive pyoderma gangrenosum. ... of the corticosteroid therapy and avoiding systemic infection through the ulcers. Combination immunosuppressant therapy ...

    Abstract An 8-year-old girl was presented to our clinic with fever, arthritis in her left knee, a necrotic right fifth toe, and multiple large deep-seated ulcerations. She was diagnosed with pyoderma gangrenosum. Treatment with corticosteroids alone was ineffective for her skin lesions, and therefore combination immunosuppressant therapy was administered. Her skin lesions rapidly improved, enabling discontinuation of the corticosteroid therapy and avoiding systemic infection through the ulcers. Combination immunosuppressant therapy may be a treatment option for patients with severe, rapidly progressive pyoderma gangrenosum.
    Sprache Englisch
    Erscheinungsdatum 2020-10-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1080/24725625.2020.1749359
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Case Report: Triple Combination Therapy for Recalcitrant Perineal Pyoderma Gangrenosum

    Shaath, Tarek S. / Om, Amit / Wolfe, Christopher M. / Cohen, George F.

    Journal of drugs in dermatology : JDD

    2019  Band 18, Heft 3, Seite(n) 307–310

    Mesh-Begriff(e) Adalimumab/administration & dosage ; Adrenal Cortex Hormones/administration & dosage ; Adult ; Anti-Inflammatory Agents/administration & dosage ; Crohn Disease/complications ; Cyclosporine/administration & dosage ; Diagnosis, Differential ; Drug Therapy, Combination ; Humans ; Immunosuppressive Agents/administration & dosage ; Male ; Perineum ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/drug therapy ; Pyoderma Gangrenosum/pathology ; Thalidomide/administration & dosage
    Chemische Substanzen Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Immunosuppressive Agents ; Thalidomide (4Z8R6ORS6L) ; Cyclosporine (83HN0GTJ6D) ; Adalimumab (FYS6T7F842)
    Sprache Englisch
    Erscheinungsdatum 2019-04-24
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting.

    Goto, Hiroyuki / Okada, Yoshimoto / Watanabe, Seimi / Danno, Kanako / Yamamoto, Shinya / Ishiura, Ryohei / Nakayama, Yuichi / Mitsui, Kohei / Ueki, Ayaka / Nakai, Yasuo / Narushima, Mitsunaga / Yamanaka, Keiichi

    Case reports in dermatology

    2021  Band 13, Heft 3, Seite(n) 497–501

    Abstract: Pyoderma gangrenosum (PG) is a relatively rare inflammatory skin disease that progressively causes ... tissue in combination with skin grafting may be necessary to promote wound healing. Our report presents ...

    Abstract Pyoderma gangrenosum (PG) is a relatively rare inflammatory skin disease that progressively causes necrotic ulceration mainly on the lower extremities and trunk. Systemic corticosteroid is considered a first-line treatment for PG as it facilitates wound healing; however, several cases where tumor necrosis factor-α inhibitors, adalimumab and infliximab, were administered showed good response. For intractable PG with a large ulcer or problematic epithelization, chemical or mechanical debridement of necrotic tissue in combination with skin grafting may be necessary to promote wound healing. Our report presents a case of intractable ulcerative PG requiring oral prednisolone and skin grafting. Although mechanical debridement was performed, granulation was poor; therefore, after the PG activity became quiescent, we utilized a vacuum-assisted closure (VAC) system to promote granulation and adaptation of the grafted skin. Although more cases are required for a definitive conclusion, the VAC system may be a choice for PG with large ulcers.
    Sprache Englisch
    Erscheinungsdatum 2021-10-21
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2505300-0
    ISSN 1662-6567
    ISSN 1662-6567
    DOI 10.1159/000519659
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Therapeutic Efficacy of the Combination Therapy of Corticosteroids and 5-Aminosalicylic Acid for Treatment of Pyoderma Gangrenosum with Ulcerative Colitis.

    Chen, Wei / Xiang, Lijuan / Li, Li

    Indian journal of dermatology

    2020  Band 65, Heft 1, Seite(n) 38–41

    Abstract: Background: Pyoderma gangrenosum (PG) in inflammatory bowel disease (IBD) is a rare cutaneous ... had multiple lesions. In total, 20/39 UC patients received the combination therapy of systemic ... considered as the first-line therapy for UC-associated PG. ...

    Abstract Background: Pyoderma gangrenosum (PG) in inflammatory bowel disease (IBD) is a rare cutaneous condition and its treatment remains controversial due to limited data.
    Aims and objectives: The purpose of this study was to investigate the characteristics and treatment response to specific therapies of IBD-associated PG.
    Methods: In this retrospective study, we reviewed a series of cases of IBD-associated PG patients who presented at our institution, and collected clinical data, such as demographics, characteristics, subtype, and disease activity of IBD and specific therapies used and their treatment response.
    Results: In total, 42 cases were identified: 69% female and 92.9% with ulcerative colitis (UC). At PG diagnosis, 93% had active and 7% inactive IBD. PG ulcers occurred predominantly on the legs (33.3%); 14.3% had multiple lesions. In total, 20/39 UC patients received the combination therapy of systemic corticosteroids and 5-aminosalicylic acid (5-ASA) with a good response in 19 patients (95%). Seven patients received the monotherapy of 5-ASA with a response rate of 43%. Five patients were successfully treated with systemic corticosteroids alone. Other patients were treated with intravenous immunoglobulin, infliximab, or cyclophosphamide alone or in combination with corticosteroids and all showed a good response.
    Conclusion: Our study indicates the therapeutic efficacy of corticosteroids in combination with 5-ASA, which may be considered as the first-line therapy for UC-associated PG.
    Sprache Englisch
    Erscheinungsdatum 2020-02-07
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.IJD_505_18
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Pyoderma gangrenosum: combination therapy with excellent results in a patient with underlying hepatitis C.

    Iardino, Alfredo / Garner, Orlando / Ahmed, Yasir / Bhairavarasu, Kalpana

    BMJ case reports

    2017  Band 2017

    Mesh-Begriff(e) Combined Modality Therapy ; Debridement ; Hepatitis, Chronic/immunology ; Hepatitis, Chronic/physiopathology ; Humans ; Immunoglobulins/therapeutic use ; Male ; Middle Aged ; Pyoderma Gangrenosum/immunology ; Pyoderma Gangrenosum/pathology ; Pyoderma Gangrenosum/therapy ; Steroids/therapeutic use ; Treatment Outcome
    Chemische Substanzen Immunoglobulins ; Steroids
    Sprache Englisch
    Erscheinungsdatum 2017-11-14
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-223113
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Successful combined antibiotic therapy with oral clindamycin and oral rifampicin for pyoderma gangrenosum in patient with PASH syndrome.

    Lamiaux, Marie / Dabouz, Fadia / Wantz, Maud / Lebas, Damien / Lasek, Audrey / Courivaud, Domitille / Modiano, Philippe

    JAAD case reports

    2017  Band 4, Heft 1, Seite(n) 17–21

    Sprache Englisch
    Erscheinungsdatum 2017-12-18
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2017.05.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Intestinal Behçet's disease with pyoderma gangrenosum successfully treated with the combination therapy of adalimumab and glucocorticoids.

    Kashiwado, Yusuke / Uchino, Ayumi / Ota, Toshiyuki / Nagano, Shuji

    Modern rheumatology

    2016  Band 28, Heft 5, Seite(n) 901–905

    Abstract: ... in the ascending colon, and hence, he was diagnosed as intestinal Behçets disease (BD) with pyoderma gangrenosum (PG ...

    Abstract A 24-year-old male presented with orogenital ulcers, folliculitis, and progressive painful skin ulcers with a raised inflammatory border. Colonoscopy revealed volcano-shaped intestinal ulcers in the ascending colon, and hence, he was diagnosed as intestinal Behçets disease (BD) with pyoderma gangrenosum (PG). Treatment with systemic glucocorticoids and adalimumab dramatically improved the patient's symptoms. Our case demonstrates that early induction of adalimumab may contribute to the successful treatment of such difficult-to-treat conditions as intestinal BD with PG.
    Mesh-Begriff(e) Adalimumab/administration & dosage ; Adalimumab/therapeutic use ; Behcet Syndrome/complications ; Behcet Syndrome/drug therapy ; Combined Modality Therapy ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Humans ; Male ; Pyoderma Gangrenosum/complications ; Pyoderma Gangrenosum/drug therapy ; Young Adult
    Chemische Substanzen Glucocorticoids ; Adalimumab (FYS6T7F842)
    Sprache Englisch
    Erscheinungsdatum 2016-05-04
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.3109/14397595.2016.1174327
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Combination of negative pressure wound therapy and systemic steroid therapy in postsurgical pyoderma gangrenosum after reduction mammoplasty; a case of proven efficacy and safety.

    Tanini, Sara / Calugi, Gianmarco / Russo, Giulia Lo

    Dermatology reports

    2017  Band 9, Heft 2, Seite(n) 7209

    Sprache Englisch
    Erscheinungsdatum 2017-12-04
    Erscheinungsland Italy
    Dokumenttyp Case Reports
    ZDB-ID 2568735-9
    ISSN 2036-7406 ; 2036-7392
    ISSN (online) 2036-7406
    ISSN 2036-7392
    DOI 10.4081/dr.2017.7209
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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