Article: Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia-a new therapeutic strategy?
Molecular and cellular pediatrics
2016 Volume 3, Issue 1, Page(s) 29
Abstract: ... functions of alveolar macrophages and dendritic cells (DCs) and also improves epithelial repair processes ... to promote differentiation, activation and mobilization of myeloid cells. In the lung, GM-CSF drives immune ... treatment strategies are still missing, research refocuses attention to lung pathology and cellular ...
| Abstract | Influenza viruses (IVs) circulate seasonally and are a common cause of respiratory infections in pediatric and adult patients. Additionally, recurrent pandemics cause massive morbidity and mortality worldwide. Infection may result in rapid progressive viral pneumonia with fatal outcome. Since accurate treatment strategies are still missing, research refocuses attention to lung pathology and cellular crosstalk to develop new therapeutic options.Alveolar epithelial cells (AECs) play an important role in orchestrating the pulmonary antiviral host response. After IV infection they release a cascade of immune mediators, one of which is granulocyte and macrophage colony-stimulating factor (GM-CSF). GM-CSF is known to promote differentiation, activation and mobilization of myeloid cells. In the lung, GM-CSF drives immune functions of alveolar macrophages and dendritic cells (DCs) and also improves epithelial repair processes through direct interaction with AECs. During IV infection, AEC-derived GM-CSF shows a lung-protective effect that is also present after local GM-CSF application. This mini-review provides an overview on GM-CSF-modulated immune responses to IV pneumonia and its therapeutic potential in severe IV pneumonia. |
|---|---|
| Keywords | covid19 |
| Language | English |
| Publishing date | 2016-08-01 |
| Publishing country | Germany |
| Document type | Journal Article ; Review |
| ZDB-ID | 2785551-X |
| ISSN | 2194-7791 |
| ISSN | 2194-7791 |
| DOI | 10.1186/s40348-016-0055-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.