Article ; Online: High Seroconversion Rate Against Severe Acute Respiratory Syndrome Coronavirus 2 in Symptomatic Pediatric Inflammatory Bowel Disease Patients.
Journal of pediatric gastroenterology and nutrition
2021 Volume 73, Issue 3, Page(s) 363–366
Abstract: ... where seroconversion against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was examined.Immunosuppressed ... inflammatory bowel disease (PIBD) is important. We describe a single-center cohort of COVID-19 PIBD patients ... rates of COVID-19 seroconversion occurred in immunosuppressed and symptomatic PIBD patients. More ...
| Abstract | Abstract: Understanding coronavirus disease 2019 (COVID-19) in pediatric inflammatory bowel disease (PIBD) is important. We describe a single-center cohort of COVID-19 PIBD patients where seroconversion against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was examined.Immunosuppressed PIBD patients at Texas Children's Hospital who tested positive for SARS-CoV-2 by nasopharyngeal reverse transcriptase polymerase chain reaction were included in the study. The clinical course of IBD, concurrent medications, COVID-19 related symptoms, SARS-CoV-2 testing date, and SARS-CoV-2 immunoglobulin G (IgG) antibody testing date and result were examined. Of 14 SARS-CoV-2 positive PIBD patients, 12 were tested for qualitative anti-SARS-CoV-2 IgG (seven with transient COVID-19 symptoms, five asymptomatic). All symptomatic (7/7) and 60% of asymptomatic (3/5) patients seroconverted. No patients required hospitalization attributed to COVID-19.High rates of COVID-19 seroconversion occurred in immunosuppressed and symptomatic PIBD patients. More research to evaluate the significance of COVID-19 seroconversion is needed. |
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| MeSH term(s) | Antibodies, Viral ; COVID-19 ; COVID-19 Testing ; Child ; Humans ; Inflammatory Bowel Diseases ; SARS-CoV-2 ; Seroconversion | |||||
| Chemical Substances | Antibodies, Viral | |||||
| Language | English | |||||
| Publishing date | 2021-06-22 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 603201-1 | |||||
| ISSN | 1536-4801 ; 0277-2116 | |||||
| ISSN (online) | 1536-4801 | |||||
| ISSN | 0277-2116 | |||||
| DOI | 10.1097/MPG.0000000000003211 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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