Article ; Online: Synovial Biopsy in the Diagnosis of Crystal-Associated Arthropathies.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
2020 Volume 26, Issue 4, Page(s) 142–146
Abstract: ... of crystal-associated arthropathies (CAAs) in a clinical setting.: Methods: In this retrospective study ...
| Abstract | Background/ objective: This study seeks to assess the utility of synovial biopsy in the diagnosis of crystal-associated arthropathies (CAAs) in a clinical setting. Methods: In this retrospective study, we reviewed biopsy reports involving synovial tissue between 1988 and 2015. We then reviewed the records of patients where the biopsy was performed for a clinical suspicion of CAA-the clinical group-and calculated the frequency of a positive diagnosis. The t test, Mann-Whitney-Wilcoxon test, and Fisher test were used to compare clinical characteristics of patients with and without a tissue diagnosis of CAA. We also reviewed cases of unexpected detection of crystalline disease involving synovial tissue-the incidental group. Results: Among 2786 biopsies involving the synovium, we identified 65 cases in the clinical group and 33 cases in the incidental group. In the clinical group, a relevant diagnosis was obtained from synovial tissue in 36.9%, and a CAA was diagnosed in 20%. Restricting analysis to clinical biopsies performed for a primary suspicion of CAA, a relevant diagnosis was obtained in 61.3%, and a CAA was diagnosed in 38.7%. The incidental group comprised 1.2% of all synovial biopsies and included 7 mass lesions. Basic calcium phosphate was not reported on any biopsy in the study period. Conclusions: Synovial biopsy is a diagnostic option when suspected CAA is resistant to conventional modes of diagnosis. Crystalline diseases should be considered in the differential diagnosis of musculoskeletal mass lesions mimicking neoplasms. |
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| MeSH term(s) | Aged ; Biopsy/methods ; Biopsy/statistics & numerical data ; Bone Neoplasms/diagnosis ; Crystal Arthropathies/diagnosis ; Crystal Arthropathies/epidemiology ; Crystal Arthropathies/pathology ; Crystal Arthropathies/physiopathology ; Diagnosis, Differential ; Female ; Gout/epidemiology ; Gout/pathology ; Gout/physiopathology ; Humans ; Incidental Findings ; Male ; Middle Aged ; Muscle Neoplasms/diagnosis ; Symptom Assessment/methods ; Symptom Assessment/statistics & numerical data ; Synovial Membrane/pathology ; United States/epidemiology |
| Language | English |
| Publishing date | 2020-05-08 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1283266-2 |
| ISSN | 1536-7355 ; 1076-1608 |
| ISSN (online) | 1536-7355 |
| ISSN | 1076-1608 |
| DOI | 10.1097/RHU.0000000000000993 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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