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  1. Article ; Online: Capacity in the time of Coronavirus.

    Ruck Keene, Alex

    International journal of law and psychiatry

    2020  Volume 70, Page(s) 101560

    Abstract: ... amended, the impact of other legislation (especially the Coronavirus Act 2020) means that duties ... to decision-making in England & Wales in respect of those with impaired decision-making capacity have been ripped up ... or apparently rendered all but unusable. Although the Mental Capacity Act 2005 itself has not been ...

    Abstract In the course of a few short weeks, many of the established legal frameworks relating to decision-making in England & Wales in respect of those with impaired decision-making capacity have been ripped up, or apparently rendered all but unusable. Although the Mental Capacity Act 2005 itself has not been amended, the impact of other legislation (especially the Coronavirus Act 2020) means that duties towards those with impaired decision-making capacity have been radically changed. This article reflects the experience of a practising barrister in England & Wales grappling with the impact of COVID-19 upon the Mental Capacity Act 2005 across a range of fields in the weeks after the world appeared to change in mid-March 2020.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/psychology ; Coronavirus Infections/therapy ; Decision Making ; England ; Human Rights/psychology ; Humans ; Mental Competency/legislation & jurisprudence ; Mental Competency/psychology ; Pandemics ; Pneumonia, Viral/psychology ; Pneumonia, Viral/therapy ; Public Health ; SARS-CoV-2 ; State Medicine ; Wales
    Keywords covid19
    Language English
    Publishing date 2020-04-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 304429-4
    ISSN 1873-6386 ; 0160-2527
    ISSN (online) 1873-6386
    ISSN 0160-2527
    DOI 10.1016/j.ijlp.2020.101560
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  2. Article: Capacity in the time of Coronavirus

    Ruck Keene, Alex

    Int J Law Psychiatry

    Abstract: ... amended, the impact of other legislation (especially the Coronavirus Act 2020) means that duties ... to decision-making in England & Wales in respect of those with impaired decision-making capacity have been ripped up ... or apparently rendered all but unusable. Although the Mental Capacity Act 2005 itself has not been ...

    Abstract In the course of a few short weeks, many of the established legal frameworks relating to decision-making in England & Wales in respect of those with impaired decision-making capacity have been ripped up, or apparently rendered all but unusable. Although the Mental Capacity Act 2005 itself has not been amended, the impact of other legislation (especially the Coronavirus Act 2020) means that duties towards those with impaired decision-making capacity have been radically changed. This article reflects the experience of a practising barrister in England & Wales grappling with the impact of COVID-19 upon the Mental Capacity Act 2005 across a range of fields in the weeks after the world appeared to change in mid-March 2020.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #47861
    Database COVID19

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  3. Article ; Online: Capacity in the time of Coronavirus

    Barrister, Alex Ruck Keene

    International Journal of Law and Psychiatry

    Abstract: ... the impact of other legislation (especially the Coronavirus Act 2020) means that duties ... to decision-making in England & Wales in respect of those with impaired decision-making capacity have been ripped up ... or apparently rendered all but unusable. Although the Mental Capacity Act 2005 itself was not amended ...

    Abstract Abstract In the course of a few short weeks, many of the established legal frameworks relating to decision-making in England & Wales in respect of those with impaired decision-making capacity have been ripped up, or apparently rendered all but unusable. Although the Mental Capacity Act 2005 itself was not amended, the impact of other legislation (especially the Coronavirus Act 2020) means that duties towards those with impaired decision-making capacity have been radically changed. This article reflects the experience of a practising barrister in England & Wales grappling with the impact of COVID-19 upon the Mental Capacity Act 2005 across a range of fields in the weeks after the world appeared to change in mid-March 2020.
    Keywords covid19
    Publisher Elsevier
    Document type Article ; Online
    DOI 10.1016/j.ijlp.2020.101560
    Database COVID19

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  4. Article ; Online: Minimizing Population Health Loss in Times of Scarce Surgical Capacity During the Coronavirus Disease 2019 Crisis and Beyond: A Modeling Study.

    Gravesteijn, Benjamin / Krijkamp, Eline / Busschbach, Jan / Geleijnse, Geert / Helmrich, Isabel Retel / Bruinsma, Sophie / van Lint, Céline / van Veen, Ernest / Steyerberg, Ewout / Verhoef, Kees / van Saase, Jan / Lingsma, Hester / Baatenburg de Jong, Rob

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2021  Volume 24, Issue 5, Page(s) 648–657

    Abstract: Objectives: Coronavirus disease 2019 has put unprecedented pressure on healthcare systems ... of surgical procedures to minimize population health loss in times of scarcity. The model results should be ... worldwide, leading to a reduction of the available healthcare capacity. Our objective was to develop ...

    Abstract Objectives: Coronavirus disease 2019 has put unprecedented pressure on healthcare systems worldwide, leading to a reduction of the available healthcare capacity. Our objective was to develop a decision model to estimate the impact of postponing semielective surgical procedures on health, to support prioritization of care from a utilitarian perspective.
    Methods: A cohort state-transition model was developed and applied to 43 semielective nonpediatric surgical procedures commonly performed in academic hospitals. Scenarios of delaying surgery from 2 weeks were compared with delaying up to 1 year and no surgery at all. Model parameters were based on registries, scientific literature, and the World Health Organization Global Burden of Disease study. For each surgical procedure, the model estimated the average expected disability-adjusted life-years (DALYs) per month of delay.
    Results: Given the best available evidence, the 2 surgical procedures associated with most DALYs owing to delay were bypass surgery for Fontaine III/IV peripheral arterial disease (0.23 DALY/month, 95% confidence interval [CI]: 0.13-0.36) and transaortic valve implantation (0.15 DALY/month, 95% CI: 0.09-0.24). The 2 surgical procedures with the least DALYs were placing a shunt for dialysis (0.01, 95% CI: 0.005-0.01) and thyroid carcinoma resection (0.01, 95% CI: 0.01-0.02).
    Conclusion: Expected health loss owing to surgical delay can be objectively calculated with our decision model based on best available evidence, which can guide prioritization of surgical procedures to minimize population health loss in times of scarcity. The model results should be placed in the context of different ethical perspectives and combined with capacity management tools to facilitate large-scale implementation.
    MeSH term(s) COVID-19/complications ; Cohort Studies ; Computer Simulation ; Global Burden of Disease ; Humans ; Life Expectancy/trends ; Population Health/statistics & numerical data ; Probability Theory ; Quality-Adjusted Life Years ; Surge Capacity/standards ; Surge Capacity/statistics & numerical data
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2020.12.010
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    Zs.A 5904: Show issues Location:
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  5. Article ; Online: Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?

    Romero, Alejandro / Ramos, Eva / López-Muñoz, Francisco / Gil-Martín, Emilio / Escames, Germaine / Reiter, Russel J

    Cellular and molecular neurobiology

    2020  Volume 42, Issue 3, Page(s) 489–500

    Abstract: ... by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequently termed the coronavirus disease 2019 (COVID-19 ...

    Abstract The world faces an exceptional new public health concern caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequently termed the coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO). Although the clinical symptoms mostly have been characterized, the scientific community still doesn´t know how SARS-CoV-2 successfully reaches and spreads throughout the central nervous system (CNS) inducing brain damage. The recent detection of SARS-CoV-2 in the cerebrospinal fluid (CSF) and in frontal lobe sections from postmortem examination has confirmed the presence of the virus in neural tissue. This finding reveals a new direction in the search for a neurotherapeutic strategy in the COVID-19 patients with underlying diseases. Here, we discuss the COVID-19 outbreak in a neuroinvasiveness context and suggest the therapeutic use of high doses of melatonin, which may favorably modulate the immune response and neuroinflammation caused by SARS-CoV-2. However, clinical trials elucidating the efficacy of melatonin in the prevention and clinical management in the COVID-19 patients should be actively encouraged.
    MeSH term(s) Animals ; Brain/drug effects ; Brain/pathology ; Brain/virology ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/pathology ; Central Nervous System/drug effects ; Central Nervous System/pathology ; Central Nervous System/virology ; Central Nervous System Agents/pharmacology ; Central Nervous System Agents/therapeutic use ; Central Nervous System Viral Diseases/drug therapy ; Central Nervous System Viral Diseases/pathology ; Humans ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; SARS-CoV-2/pathogenicity
    Chemical Substances Central Nervous System Agents ; Neuroprotective Agents ; Melatonin (JL5DK93RCL)
    Keywords covid19
    Language English
    Publishing date 2020-08-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 283404-2
    ISSN 1573-6830 ; 0272-4340
    ISSN (online) 1573-6830
    ISSN 0272-4340
    DOI 10.1007/s10571-020-00938-8
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    Zs.A 1727: Show issues Location:
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  6. Article: Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?

    Romero, Alejandro / Ramos, Eva / López-Muñoz, Francisco / Gil-Martín, Emilio / Escames, Germaine / Reiter, Russel J

    Cell. mol. neurobiol

    Abstract: ... by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequently termed the coronavirus disease 2019 (COVID-19 ...

    Abstract The world faces an exceptional new public health concern caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequently termed the coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO). Although the clinical symptoms mostly have been characterized, the scientific community still doesn´t know how SARS-CoV-2 successfully reaches and spreads throughout the central nervous system (CNS) inducing brain damage. The recent detection of SARS-CoV-2 in the cerebrospinal fluid (CSF) and in frontal lobe sections from postmortem examination has confirmed the presence of the virus in neural tissue. This finding reveals a new direction in the search for a neurotherapeutic strategy in the COVID-19 patients with underlying diseases. Here, we discuss the COVID-19 outbreak in a neuroinvasiveness context and suggest the therapeutic use of high doses of melatonin, which may favorably modulate the immune response and neuroinflammation caused by SARS-CoV-2. However, clinical trials elucidating the efficacy of melatonin in the prevention and clinical management in the COVID-19 patients should be actively encouraged.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #706891
    Database COVID19

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  7. Article ; Online: Impact of COVID-19 on the capacity to self-manage health and chronic conditions.

    Russell, Andrea / Filec, Sarah / Serper, Marina / Opsasnick, Lauren / Batio, Stephanie / O'Conor, Rachel M / Curtis, Laura / Kwasny, Mary / Benavente, Julia Yoshino / Wismer, Guisselle / Bonham, Morgan / Zheng, Pauline / Lovett, Rebecca / Arvanitis, Marina / Ladner, Daniela P / McCaffery, Kirsten / Linder, Jeffrey A / Bailey, Stacy Cooper / Wolf, Michael S

    PEC innovation

    2023  Volume 2, Page(s) 100163

    Abstract: ... to the coronavirus.: Conclusions: Mental well-being, lifestyle behaviors, self-management capacity, and healthcare ... data collection at both timepoints. One in five (20.7%) participants experienced stress due to the coronavirus ... most or all the time and rates of negative well-being were high (WHO-5 Index mean = 58.7%). Almost ...

    Abstract Objective: To investigate well-being, lifestyle behaviors, self-management capacity and healthcare utilization among adults with chronic conditions at the outbreak of the COVID-19 pandemic.
    Methods: Data was collected from two interviewer-administered telephone surveys conducted between March 27 - May 22, 2020. Participants were patients at Chicago-area clinics. Self-report and validated measures were used for study-related outcomes.
    Results: A total of 553 participants (age range 23-88) completed data collection at both timepoints. One in five (20.7%) participants experienced stress due to the coronavirus most or all the time and rates of negative well-being were high (WHO-5 Index mean = 58.7%). Almost a quarter (22.3%) engaged in hazardous drinking and 79.7% reported insufficient physical activity. Nearly one in four participants (23.7%) avoided seeking medical care due to worry about COVID-19. In multivariable analyses, greater COVID-19 related stress was associated with less physical activity, lower self-efficacy, greater difficulty managing health and medications, and delays in seeking medical care due to the coronavirus.
    Conclusions: Mental well-being, lifestyle behaviors, self-management capacity, and healthcare utilization were impacted in the months following the COVID outbreak.
    Innovation: These findings suggest health systems should implement proactive measures for detecting and treating emotional and behavioral COVID-related concerns.
    Language English
    Publishing date 2023-05-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-6282
    ISSN (online) 2772-6282
    DOI 10.1016/j.pecinn.2023.100163
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  8. Article: Assessment of Exercise Capacity of Individuals with Long COVID: A Cross-sectional Study.

    Yelin, Dana / Levi, Ran / Babu, Chinanit / Moshe, Roi / Shitenberg, Dorit / Atamna, Alaa / Tishler, Ori / Babich, Tanya / Shapira-Lichter, Irit / Abecasis, Donna / Cohen Zubary, Nira / Leibovici, Leonard / Yahav, Dafna / Margalit, Ili

    The Israel Medical Association journal : IMAJ

    2023  Volume 25, Issue 2, Page(s) 83–87

    Abstract: Background: Clinical investigations of long-term effects of coronavirus disease 2019 (COVID-19 ... are rarely translated to objective findings.: Objectives: To assess the functional capacity ... P = 0.013) and rose by 2.7 meters per each 1% increase in the diffusing capacity of carbon monoxide ...

    Abstract Background: Clinical investigations of long-term effects of coronavirus disease 2019 (COVID-19) are rarely translated to objective findings.
    Objectives: To assess the functional capacity of individuals reported on deconditioning that hampered their return to their pre-COVID routine.
    Methods: Assessment included the 6-minute walk test (6MWT) and the 30-second sit-to-stand test (30-STST). We compared the expected and observed scores using the Wilcoxon signed-rank test. Predictors of test scores were identified using linear regression models.
    Results: We included 49 individuals, of whom 38 (77.6%) were recovering from mild COVID-19. Twenty-seven (55.1%) individuals had a 6MWT score lower than 80% of expected. The average 6MWT scores were 129.5 ± 121.2 meters and 12.2 ± 5.0 repeats lower than expected scores, respectively (P < 0.001 for both). The 6MWT score was 107.3 meters lower for individuals with severe COVID-19 (P = 0.013) and rose by 2.7 meters per each 1% increase in the diffusing capacity of carbon monoxide (P = 0.007). The 30-STST score was 3.0 repeats lower for individuals who reported moderate to severe myalgia (P = 0.038).
    Conclusions: Individuals with long COVID who report on deconditioning exhibit significantly decreased physical capacity, even following mild acute illness. Risk factors include severe COVID-19 and impaired diffusing capacity or myalgia during recovery.
    MeSH term(s) Humans ; Exercise Test ; Post-Acute COVID-19 Syndrome ; Cross-Sectional Studies ; Exercise Tolerance ; Myalgia ; COVID-19
    Language English
    Publishing date 2023-02-25
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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    Zs.A 5470: Show issues Location:
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  9. Book ; Online: Capacity Constraint Analysis Using Object Detection for Smart Manufacturing

    Ahmad, Hafiz Mughees / Rahimi, Afshin / Hayat, Khizer

    2024  

    Abstract: ... by capacity constraints after Coronavirus Disease (COVID-19) require non-invasive methods for in-depth ... We identified that the Station C is only 70.6% productive through 6 months. Additionally, the time spent ... and effectively managing labor and material over time. ...

    Abstract The increasing popularity of Deep Learning (DL) based Object Detection (OD) methods and their real-world applications have opened new venues in smart manufacturing. Traditional industries struck by capacity constraints after Coronavirus Disease (COVID-19) require non-invasive methods for in-depth operations' analysis to optimize and increase their revenue. In this study, we have initially developed a Convolutional Neural Network (CNN) based OD model to tackle this issue. This model is trained to accurately identify the presence of chairs and individuals on the production floor. The identified objects are then passed to the CNN based tracker, which tracks them throughout their life cycle in the workstation. The extracted meta-data is further processed through a novel framework for the capacity constraint analysis. We identified that the Station C is only 70.6% productive through 6 months. Additionally, the time spent at each station is recorded and aggregated for each object. This data proves helpful in conducting annual audits and effectively managing labor and material over time.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; I.2.10 ; I.4.8 ; I.4.9 ; I.5.1 ; I.5.4
    Subject code 006
    Publishing date 2024-01-31
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Lung Diffusion Capacity in Patients With Bilateral COVID-19 Pneumonia: A Three-Month Follow-Up Study.

    Vasilj, Marina / Galic, Kristina / Zovko, Tanja / Kraljevic, Gordana / Pravdic, Nikolina / Saric-Zolj, Belma / Goluza Sesar, Marija / Pravdic, Danijel

    Cureus

    2024  Volume 16, Issue 4, Page(s) e58897

    Abstract: ... year-old patients, COVID-19 infection confirmed using real-time RT-PCR, radiologically confirmed ... Objectives: The aim of this study was to determine the short-term consequences of coronavirus ... bilateral COVID-19 pneumonia, and diffusion capacity of the lungs for carbon monoxide (DLCO) one and three ...

    Abstract Objectives: The aim of this study was to determine the short-term consequences of coronavirus disease 2019 (COVID-19) infection on pulmonary diffusion in patients with severe (but not critical) and moderately severe COVID-19 pneumonia during three months after COVID-19 infection.
    Methods: A prospective study included 81 patients with an RT-PCR-test confirmed diagnosis of COVID-19 infection treated in the COVID Department of Lung Diseases of University Clinical Hospital Mostar. Inclusion criteria were ≥18-year-old patients, COVID-19 infection confirmed using real-time RT-PCR, radiologically confirmed bilateral COVID-19 pneumonia, and diffusion capacity of the lungs for carbon monoxide (DLCO) one and three months after COVID-19 infection. The pulmonary function was tested using the MasterScreen Body Jaeger (Jaeger Corporation, Omaha, USA) and MasterScreen PFT Jaeger (Jaeger Corporation, Omaha, USA) according to American Thoracic Society guidelines one and three months after COVID-19 infection.
    Results: Forced vital capacity significantly increased three months after COVID-19 infection compared to the first-month control (p<0.0005). Also, a statistically significant increase in the FEV1 value (p<0.0005), FEV1%FVC ratio (p<0.005), DLCO/SB (p<0.0005), DLCO/VA value (p<0.0005), and total lung capacity (TLC) (p<0.0005) was observed in all patients.
    Conclusion: Our study showed that recovery of DLCO/VA and spirometry parameters was complete after three months, while DLCO/SB was below normal values even after three months. Therefore, one month after the COVID-19 infection patients had partial recovery of lung function, while a significant recovery of lung function was observed three months after the COVID-19 infection.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.58897
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