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Article ; Online: Impact of pre-existing heart failure on 60-day outcomes in patients hospitalized with COVID-19.

Ruge, Max / Gomez, Joanne Michelle D / du Fay de Lavallaz, Jeanne / Hlepas, Alexander / Rahman, Annas / Patel, Priya / Hoster, Clay / Lavani, Prutha / Nair, Gatha G / Jahan, Nusrat / Alan Simmons, J / Rao, Anupama K / Cotts, William / Williams, Kim / Volgman, Annabelle Santos / Marinescu, Karolina / Suboc, Tisha

American heart journal plus : cardiology research and practice

2021  Volume 4, Page(s) 100022

Abstract: ... with higher case fatality rates. However, the relationship between COVID-19 and heart failure (HF) is unclear ... for these numerous factors, those with HF appear to be at no higher risk of 60-day mortality from COVID-19 but are ... in both the HF and no HF groups. HF patients did not have lower 60-day mortality (OR 0.81; : Conclusions ...

Abstract Background: In the coronavirus disease 2019 (COVID-19) global pandemic, patients with cardiovascular disease represent a vulnerable population with higher risk for contracting COVID-19 and worse prognosis with higher case fatality rates. However, the relationship between COVID-19 and heart failure (HF) is unclear, specifically whether HF is an independent risk factor for severe infection or if other accompanying comorbidities are responsible for the increased risk.
Methods: This is a retrospective analysis of 1331 adult patients diagnosed with COVID-19 infection between March and June 2020 admitted at Rush University System for Health (RUSH) in metropolitan Chicago, Illinois, USA. Patients with history of HF were identified by International Classification of Disease, Tenth Revision (ICD-10) code assignments extracted from the electronic medical record. Propensity score matching was utilized to control for the numerous confounders, and univariable logistic regression was performed to assess the relationship between HF and 60-day morbidity and mortality outcomes.
Results: The propensity score matched cohort consisted of 188 patients in both the HF and no HF groups. HF patients did not have lower 60-day mortality (OR 0.81;
Conclusions: This study highlights the complex network of confounders present between HF and COVID-19. When balanced for these numerous factors, those with HF appear to be at no higher risk of 60-day mortality from COVID-19 but are at increased risk for morbidity.
Language English
Publishing date 2021-06-15
Publishing country United States
Document type Journal Article
ISSN 2666-6022
ISSN (online) 2666-6022
DOI 10.1016/j.ahjo.2021.100022
Database MEDical Literature Analysis and Retrieval System OnLINE

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