Article ; Online: NETosis in Wound Healing: When Enough Is Enough.
2021 Volume 10, Issue 3
Abstract: ... in COVID-19 patients. The positive effects of NETs on wound healing have been linked to their antimicrobial ... physiological NETs effects on wound healing that are worthy of a broader research effort. ... collectively called NETosis. NETosis, initially only considered a defensive/apoptotic mechanism, is now ...
| Abstract | The neutrophils extracellular traps (NETs) are a meshwork of chromatin, histonic and non-histonic proteins, and microbicidal agents spread outside the cell by a series of nuclear and cytoplasmic events, collectively called NETosis. NETosis, initially only considered a defensive/apoptotic mechanism, is now considered an extreme defensive solution, which in particular situations induces strong negative effects on tissue physiology, causing or exacerbating pathologies as recently shown in NETs-mediated organ damage in COVID-19 patients. The positive effects of NETs on wound healing have been linked to their antimicrobial activity, while the negative effects appear to be more common in a plethora of pathological conditions (such as diabetes) and linked to a NETosis upregulation. Recent evidence suggests there are other positive physiological NETs effects on wound healing that are worthy of a broader research effort. |
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| MeSH term(s) | Animals ; COVID-19/immunology ; Extracellular Traps/immunology ; Humans ; Immunity, Innate ; Inflammation/immunology ; Neutrophils/immunology ; Wound Healing |
| Language | English |
| Publishing date | 2021-02-25 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2661518-6 |
| ISSN | 2073-4409 ; 2073-4409 |
| ISSN (online) | 2073-4409 |
| ISSN | 2073-4409 |
| DOI | 10.3390/cells10030494 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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