Article ; Online: TAK1 regulates resident macrophages by protecting lysosomal integrity.
2017 Volume 8, Issue 2, Page(s) e2598
Abstract: ... Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity ... during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1 ...
| Abstract | Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1 |
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| MeSH term(s) | Animals ; Cell Death/physiology ; Cell Survival/physiology ; Embryonic Development/physiology ; Lung/metabolism ; Lysosomes/metabolism ; MAP Kinase Kinase Kinases/metabolism ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Protective Agents/metabolism ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Signal Transduction/physiology ; Thymocytes/physiology ; Thymus Gland/metabolism ; Toll-Like Receptors/metabolism |
| Chemical Substances | Protective Agents ; Receptors, Tumor Necrosis Factor, Type I ; Toll-Like Receptors ; MAP Kinase Kinase Kinases (EC 2.7.11.25) ; MAP kinase kinase kinase 7 (EC 2.7.11.25) |
| Language | English |
| Publishing date | 2017-02-09 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural |
| ZDB-ID | 2541626-1 |
| ISSN | 2041-4889 ; 2041-4889 |
| ISSN (online) | 2041-4889 |
| ISSN | 2041-4889 |
| DOI | 10.1038/cddis.2017.23 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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