Article ; Online: Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide.
2020 Volume 95, Issue 7, Page(s) 1445–1453
Abstract: ... outcomes with COVID-19 infection, including respiratory failure, need for mechanical ventilation, and ... Obesity has reached epidemic proportions in the United States and in much of the westernized world ... which means that adipose tissue may be vulnerable to COVID-19 infection. Obese patients also have worse ...
Abstract | Obesity has reached epidemic proportions in the United States and in much of the westernized world, contributing to considerable morbidity. Several of these obesity-related morbidities are associated with greater risk for death with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 penetrates human cells through direct binding with angiotensin-converting enzyme 2 receptors on the cell surface. Angiotensin-converting enzyme 2 expression in adipose tissue is higher than that in lung tissue, which means that adipose tissue may be vulnerable to COVID-19 infection. Obese patients also have worse outcomes with COVID-19 infection, including respiratory failure, need for mechanical ventilation, and higher mortality. Clinicians need to be more aggressive when treating obese, especially severely obese, patients with COVID-19 infection. |
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MeSH term(s) | Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Obesity/complications ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Prognosis ; SARS-CoV-2 |
Keywords | covid19 |
Language | English |
Publishing date | 2020-05-19 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 124027-4 |
ISSN | 1942-5546 ; 0025-6196 |
ISSN (online) | 1942-5546 |
ISSN | 0025-6196 |
DOI | 10.1016/j.mayocp.2020.05.006 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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