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  1. Article ; Online: Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis.

    Santoso, Anwar / Pranata, Raymond / Wibowo, Arief / Al-Farabi, Makhyan Jibril / Huang, Ian / Antariksa, Budhi

    The American journal of emergency medicine

    2020  Volume 44, Page(s) 352–357

    Abstract: ... associated with higher mortality (RR 7.95 [5.12, 12.34], : Conclusion: Cardiac injury is associated ... with mortality, need for ICU care, and severity of disease in patients with COVID-19. ... between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory ...

    Abstract Background: In this systematic review and meta-analysis, we aimed to explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia.
    Methods: We performed a comprehensive literature search from several databases. Definition of cardiac injury follows that of the included studies, which includes highly sensitive cardiac troponin I (hs-cTnl) >99th percentile.The primary outcome was mortality, and the secondary outcomes were ARDS, the need for ICU care, and severe COVID-19. ARDS and severe COVID-19 were defined per the World Health Organization (WHO) interim guidance of severe acute respiratory infection (SARI) of COVID-19.
    Results: There were a total of 2389 patients from 13 studies. This meta-analysis showed that cardiac injury was associated with higher mortality (RR 7.95 [5.12, 12.34],
    Conclusion: Cardiac injury is associated with mortality, need for ICU care, and severity of disease in patients with COVID-19.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/mortality ; Critical Illness/mortality ; Heart Diseases/etiology ; Heart Diseases/mortality ; Heart Diseases/virology ; Humans ; Intensive Care Units/statistics & numerical data ; Risk Factors
    Keywords covid19
    Language English
    Publishing date 2020-04-19
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2020.04.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis

    Santoso, Anwar / Pranata, Raymond / Wibowo, Arief / Al-Farabi, Makhyan Jibril / Huang, Ian / Antariksa, Budhi

    Am. j. emerg. med

    Abstract: ... is associated with mortality, need for ICU care, and severity of disease in patients with COVID-19. ... associated with higher mortality (RR 7.95 [5.12, 12.34], p < 0.001; I2: 65%). Cardiac injury was associated ... between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory ...

    Abstract BACKGROUND: In this systematic review and meta-analysis, we aimed to explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia. METHODS: We performed a comprehensive literature search from several databases. Definition of cardiac injury follows that of the included studies, which includes highly sensitive cardiac troponin I (hs-cTnl) >99th percentile.The primary outcome was mortality, and the secondary outcomes were ARDS, the need for ICU care, and severe COVID-19. ARDS and severe COVID-19 were defined per the World Health Organization (WHO) interim guidance of severe acute respiratory infection (SARI) of COVID-19. RESULTS: There were a total of 2389 patients from 13 studies. This meta-analysis showed that cardiac injury was associated with higher mortality (RR 7.95 [5.12, 12.34], p < 0.001; I2: 65%). Cardiac injury was associated with higher need for ICU care (RR 7.94 [1.51, 41.78], p = 0.01; I2: 79%), and severe COVID-19 (RR 13.81 [5.52, 34.52], p < 0.001; I2: 0%). The cardiac injury was not significant for increased risk of ARDS (RR 2.57 [0.96, 6.85], p = 0.06; I2: 84%). The level of hs-cTnI was higher in patients with primary + secondary outcome (mean difference 10.38 pg/mL [4.44, 16.32], p = 0.002; I2: 0%). CONCLUSION: Cardiac injury is associated with mortality, need for ICU care, and severity of disease in patients with COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #72504
    Database COVID19

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  3. Article ; Online: Cardiac injury associated with severe disease or ICU admission and death in hospitalized patients with COVID-19: a meta-analysis and systematic review.

    Li, Xinye / Pan, Xiandu / Li, Yanda / An, Na / Xing, Yanfen / Yang, Fan / Tian, Li / Sun, Jiahao / Gao, Yonghong / Shang, Hongcai / Xing, Yanwei

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 468

    Abstract: Background: Cardiac injury is now a common complication of coronavirus disease (COVID-19 ... but it remains unclear whether cardiac injury-related biomarkers can be independent predictors of mortality and ... with the development of severe disease and need for ICU admission, and the mortality is significantly higher ...

    Abstract Background: Cardiac injury is now a common complication of coronavirus disease (COVID-19), but it remains unclear whether cardiac injury-related biomarkers can be independent predictors of mortality and severe disease development or intensive care unit (ICU) admission.
    Methods: Two investigators searched the PubMed, EMBASE, Cochrane Library, MEDLINE, Chinese National Knowledge Infrastructure (CNKI), Wanfang, MedRxiv, and ChinaXiv databases for articles published through March 30, 2020. Retrospective studies assessing the relationship between the prognosis of COVID-19 patients and levels of troponin I (TnI) and other cardiac injury biomarkers (creatine kinase [CK], CK myocardial band [CK-MB], lactate dehydrogenase [LDH], and interleukin-6 [IL-6]) were included. The data were extracted independently by two investigators.
    Results: The analysis included 23 studies with 4631 total individuals. The proportions of severe disease, ICU admission, or death among patients with non-elevated TnI (or troponin T [TnT]), and those with elevated TnI (or TnT) were 12.0% and 64.5%, 11.8% and 56.0%, and 8.2% and. 59.3%, respectively. Patients with elevated TnI levels had significantly higher risks of severe disease, ICU admission, and death (RR 5.57, 95% CI 3.04 to 10.22, P < 0.001; RR 6.20, 95% CI 2.52 to 15.29, P < 0.001; RR 5.64, 95% CI 2.69 to 11.83, P < 0.001). Patients with an elevated CK level were at significantly increased risk of severe disease or ICU admission (RR 1.98, 95% CI 1.50 to 2.61, P < 0.001). Patients with elevated CK-MB levels were at a higher risk of developing severe disease or requiring ICU admission (RR 3.24, 95% CI 1.66 to 6.34, P = 0.001). Patients with newly occurring arrhythmias were at higher risk of developing severe disease or requiring ICU admission (RR 13.09, 95% CI 7.00 to 24.47, P < 0.001). An elevated IL-6 level was associated with a higher risk of developing severe disease, requiring ICU admission, or death.
    Conclusions: COVID-19 patients with elevated TnI levels are at significantly higher risk of severe disease, ICU admission, and death. Elevated CK, CK-MB, LDH, and IL-6 levels and emerging arrhythmia are associated with the development of severe disease and need for ICU admission, and the mortality is significantly higher in patients with elevated LDH and IL-6 levels.
    MeSH term(s) Biomarkers/blood ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Heart Injuries/blood ; Heart Injuries/etiology ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Predictive Value of Tests ; Risk Assessment ; Severity of Illness Index ; Troponin I/blood
    Chemical Substances Biomarkers ; Troponin I
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03183-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19

    Santoso, Anwar / Pranata, Raymond / Wibowo, Arief / Al-Farabi, Makhyan Jibril / Huang, Ian / Antariksa, Budhi

    The American Journal of Emergency Medicine ; ISSN 0735-6757

    A meta-analysis

    2020  

    Keywords Emergency Medicine ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.ajem.2020.04.052
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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