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  1. Article ; Online: Penile and generalised calciphylaxis in peritoneal dialysis.

    Sarkis, Edmond

    BMJ case reports

    2015  Volume 2015

    Abstract: This is a rare case of penile and generalised calciphylaxis. We describe the case ... for penile debridement and started on antibiotics. He was treated with sodium thiosulfate and switched ... on peritoneal dialysis. Skin findings turned out to be calciphyactic lesions. The patient was taken to the operating room ...

    Abstract This is a rare case of penile and generalised calciphylaxis. We describe the case of a patient admitted to our hospital for septic shock and necrotic skin findings, end-stage renal disease on peritoneal dialysis. Skin findings turned out to be calciphyactic lesions. The patient was taken to the operating room for penile debridement and started on antibiotics. He was treated with sodium thiosulfate and switched to haemodialysis. Calciphylaxis is a rare disease in which the treatment is basically supportive. Further studies are needed to identify the risk factors, mechanisms of disease and treatment modalities.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Calciphylaxis/complications ; Calciphylaxis/etiology ; Calciphylaxis/pathology ; Calciphylaxis/prevention & control ; Debridement/methods ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Necrosis/drug therapy ; Necrosis/etiology ; Necrosis/surgery ; Penile Diseases/drug therapy ; Penile Diseases/etiology ; Penile Diseases/pathology ; Penile Diseases/surgery ; Peritoneal Dialysis/adverse effects ; Renal Dialysis/methods ; Shock, Septic/etiology ; Thiosulfates/administration & dosage
    Chemical Substances Anti-Bacterial Agents ; Thiosulfates ; sodium thiosulfate (HX1032V43M)
    Language English
    Publishing date 2015-04-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2014-209153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Penile necrosis due to calciphylaxis in peritoneal dyalisis patient

    Dahril Dahril / Fitro Manurun / Rovy Pratama

    Bali Medical Journal, Vol 9, Iss 1, Pp 163-

    a case report

    2020  Volume 166

    Abstract: ... and antibiotic. Conclusion: Calciphylaxis in peritoneal dialysis patients as reported in this case was ... from urethra and undersurface of penile lesion. Laboratory examination showed elevated calcium level of 7.3 mg ... cholesterol embolism. The treatment varies, from surgical to conservative, and is usually depends on patient’s general ...

    Abstract Introduction: Calciphylaxis (or calcific uremic arteriolopathy) is a life-threatening condition that affects 1–4% of patients with end-stage renal disease (ESRD). Penile necrosis is one of the complications of calciphylaxis that occur in ESRD patients undergone haemodialysis. Although rarely happen, this condition is potentially life-threatening and usually has a poor prognosis. It is associated with diabetes mellitus (DM), cholesterol embolism. The treatment varies, from surgical to conservative, and is usually depends on patient’s general condition. Case presentation : A 41-years-old male, known to have ESRD and underwent hemodialysis for 1 year in 2014, but has been switched to peritoneal dialysis ever since, presented with complaints of severe pain, purulent and progressive necrosis of glans penis within the last two months, and history of long-term DM and hypertension. Physical examination showed that the patient was alert, with blood pressure of 141/80 mmHg, pulse rate of 88 bpm, respiration rate of 20 times per minute, and temperature of 36.8ºC. A yellow purulent tissue was noticed over the glans penis, foul-smelling discharge was observed from urethra and undersurface of penile lesion. Laboratory examination showed elevated calcium level of 7.3 mg/dL. Ultrasound revealed multiple calcifications at the base of penis, hypoechoic lesion, nearly circular, irregular border, likely sac with thin wall, attached to the gland penis, and filled with exudate. Doppler confirmation showed avascular area. The patient was treated with partial penectomy, debridement, and antibiotic. Conclusion: Calciphylaxis in peritoneal dialysis patients as reported in this case was rarely found. Although the treatment is still debatable, however, we decided to impose surgical approach in this patient along with antibiotics. Despite its poor prognosis, the patient in this case showed improvement after the procedure.
    Keywords calciphylaxis ; end-stage renal disease ; penile necrosis ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher DiscoverSys
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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