Article ; Online: Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19).
2021 Volume 295, Page(s) 198283
Abstract: The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 ... patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 ... patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and ...
| Abstract | The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity. |
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| MeSH term(s) | Adult ; Aged ; COVID-19/immunology ; Female ; Humans ; Interferon Type I/genetics ; Interferons/genetics ; Male ; Middle Aged ; Oropharynx/immunology ; SARS-CoV-2 ; Severity of Illness Index | |||||
| Chemical Substances | Interferon Type I ; interferon type III ; Interferons (9008-11-1) | |||||
| Language | English | |||||
| Publishing date | 2021-01-05 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 605780-9 | |||||
| ISSN | 1872-7492 ; 0168-1702 | |||||
| ISSN (online) | 1872-7492 | |||||
| ISSN | 0168-1702 | |||||
| DOI | 10.1016/j.virusres.2020.198283 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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