Article ; Online: Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.
2017 Volume 6, Issue 23
Abstract: ... of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and ... This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity ... Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding ...
| Abstract | Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad-spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure-activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad-spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer-based antivirals and represent promising candidates for further development as preventive microbicides. |
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| MeSH term(s) | Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Chlorocebus aethiops ; Ebolavirus/metabolism ; HEK293 Cells ; Humans ; Polymers/chemistry ; Polymers/pharmacology ; SARS Virus/metabolism ; Vero Cells ; Virus Diseases/drug therapy ; Virus Diseases/metabolism ; Virus Diseases/pathology ; Zika Virus/metabolism | |||||
| Chemical Substances | Antiviral Agents ; Polymers | |||||
| Keywords | covid19 | |||||
| Language | English | |||||
| Publishing date | 2017-09-25 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2649576-4 | |||||
| ISSN | 2192-2659 ; 2192-2640 | |||||
| ISSN (online) | 2192-2659 | |||||
| ISSN | 2192-2640 | |||||
| DOI | 10.1002/adhm.201700748 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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