Article: Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms.
2004 Volume 55, Issue 5, Page(s) 734–737
Abstract: ... of a novel dual-function ion channel/kinase protein have recently converged with the identification ... into vertebrate magnesium regulatory mechanisms. ... Although magnesium is the dominant divalent intracellular cation and is required for the function ...
| Abstract | Although magnesium is the dominant divalent intracellular cation and is required for the function of diverse types of enzymes that participate in virtually every cellular process, the molecular mechanisms that regulate its homeostasis are poorly understood. Electrophysiologic and biochemical investigations of a novel dual-function ion channel/kinase protein have recently converged with the identification of the gene locus for an autosomal recessive form of inherited hypomagnesemia to provide new insight into vertebrate magnesium regulatory mechanisms. |
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| MeSH term(s) | Animals ; Biological Transport ; Cations ; Cations, Divalent ; Electrophysiology ; Humans ; Ion Channels/chemistry ; Ion Channels/physiology ; Magnesium/chemistry ; Membrane Proteins/physiology ; Models, Biological ; Protein Kinases/chemistry ; Protein Kinases/physiology ; Protein-Serine-Threonine Kinases ; TRPM Cation Channels | ||||||||||
| Chemical Substances | Cations ; Cations, Divalent ; Ion Channels ; Membrane Proteins ; TRPM Cation Channels ; TRPM6 protein, human ; Protein Kinases (EC 2.7.-) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TRPM7 protein, human (EC 2.7.11.1) ; Magnesium (I38ZP9992A) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2004-05 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review | ||||||||||
| ZDB-ID | 4411-8 | ||||||||||
| ISSN | 1530-0447 ; 0031-3998 | ||||||||||
| ISSN (online) | 1530-0447 | ||||||||||
| ISSN | 0031-3998 | ||||||||||
| DOI | 10.1203/01.PDR.0000117848.37520.A2 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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