Article ; Online: COVID-19 mortality among kidney transplant candidates is strongly associated with social determinants of health.
2021 Volume 21, Issue 7, Page(s) 2563–2572
Abstract: ... 19 mortality. Among kidney transplant candidates in the United States, social determinants of health ... associated with COVID-19 mortality among kidney transplant candidates from the National Scientific Registry ... have been shown to be particularly associated with COVID-19 mortality including demographic ...
| Abstract | The COVID-19 pandemic has affected all portions of the global population. However, many factors have been shown to be particularly associated with COVID-19 mortality including demographic characteristics, behavior, comorbidities, and social conditions. Kidney transplant candidates may be particularly vulnerable to COVID-19 as many are dialysis-dependent and have comorbid conditions. We examined factors associated with COVID-19 mortality among kidney transplant candidates from the National Scientific Registry of Transplant Recipients from March 1 to December 1, 2020. We evaluated crude rates and multivariable incident rate ratios (IRR) of COVID-19 mortality. There were 131 659 candidates during the study period with 3534 all-cause deaths and 384 denoted a COVID-19 cause (5.00/1000 person years). Factors associated with increased COVID-19 mortality included increased age, males, higher body mass index, and diabetes. In addition, Blacks (IRR = 1.96, 95% C.I.: 1.43-2.69) and Hispanics (IRR = 3.38, 95% C.I.: 2.46-4.66) had higher COVID-19 mortality relative to Whites. Patients with lower educational attainment, high school or less (IRR = 1.93, 95% C.I.: 1.19-3.12, relative to post-graduate), Medicaid insurance (IRR = 1.73, 95% C.I.: 1.26-2.39, relative to private), residence in most distressed neighborhoods (fifth quintile IRR = 1.93, 95% C.I.: 1.28-2.90, relative to first quintile), and most urban and most rural had higher adjusted rates of COVID-19 mortality. Among kidney transplant candidates in the United States, social determinants of health in addition to demographic and clinical factors are significantly associated with COVID-19 mortality. |
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| MeSH term(s) | COVID-19 ; Humans ; Kidney Transplantation/adverse effects ; Male ; Pandemics ; SARS-CoV-2 ; Social Determinants of Health ; United States/epidemiology | |||||
| Language | English | |||||
| Publishing date | 2021-04-08 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. | |||||
| ZDB-ID | 2060594-8 | |||||
| ISSN | 1600-6143 ; 1600-6135 | |||||
| ISSN (online) | 1600-6143 | |||||
| ISSN | 1600-6135 | |||||
| DOI | 10.1111/ajt.16578 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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