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  1. Article ; Online: Pulmonary Vascular Pathology in Covid-19.

    Som, Avik / Lang, Min / Little, Brent

    The New England journal of medicine

    2020  Volume 383, Issue 9, Page(s) 887

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Thrombosis
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2022068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pulmonary Vascular Pathology in Covid-19.

    Scholkmann, Felix / Nicholls, John

    The New England journal of medicine

    2020  Volume 383, Issue 9, Page(s) 887–888

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Thrombosis
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2022068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pulmonary Vascular Pathology in Covid-19.

    Burel-Vandenbos, Fanny / Cardot-Leccia, Nathalie / Passeron, Thierry

    The New England journal of medicine

    2020  Volume 383, Issue 9, Page(s) 886–887

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Thrombosis
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2022068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pulmonary Vascular Pathology in Covid-19. Reply.

    Ackermann, Maximilian / Mentzer, Steven J / Jonigk, Danny

    The New England journal of medicine

    2020  Volume 383, Issue 9, Page(s) 888–889

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/mortality ; Coronavirus Infections/pathology ; Endothelium, Vascular/pathology ; Endothelium, Vascular/virology ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2022068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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  9. Article ; Online: Autopsy-Based Pulmonary and Vascular Pathology: Pulmonary Endotheliitis and Multi-Organ Involvement in COVID-19 Associated Deaths.

    Haberecker, Martina / Schwarz, Esther Irene / Steiger, Peter / Frontzek, Karl / Scholkmann, Felix / Zeng, Xiankun / Höller, Sylvia / Moch, Holger / Varga, Zsuzsanna

    Respiration; international review of thoracic diseases

    2021  Volume 101, Issue 2, Page(s) 155–165

    Abstract: ... in pulmonary and in extrapulmonary sites. Eight patients died due to COVID-19 associated respiratory failure ... organ involvement (p = 0.026, p = 0.006) correlated significantly with COVID-19 associated death ... pathology.: Methods: Fifteen SARS-CoV-2 positive autopsies with clinically distinct presentations (age 22 ...

    Abstract Background: Findings from autopsies have provided evidence on systemic microvascular damage as one of the underlying mechanisms of Coronavirus disease 2019 (CO-VID-19). The aim of this study was to correlate autopsy-based cause of death in SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients with chest imaging and severity grade of pulmonary and systemic morphological vascular pathology.
    Methods: Fifteen SARS-CoV-2 positive autopsies with clinically distinct presentations (age 22-89 years) were retrospectively analyzed with focus on vascular, thromboembolic, and ischemic changes in pulmonary and in extrapulmonary sites. Eight patients died due to COVID-19 associated respiratory failure with diffuse alveolar damage in various stages and/or multi-organ failure, whereas other reasons such as cardiac decompensation, complication of malignant tumors, or septic shock were the cause of death in 7 further patients. The severity of gross and histopathological changes was semi-quantitatively scored as 0 (absent), 1 (mild), and 3 (severe). Severity scores between the 2 groups were correlated with selected clinical parameters, initial chest imaging, autopsy-based cause of death, and compared using Pearson χ2 and Mann-Whitney U tests.
    Results: Severe pulmonary endotheliitis (p = 0.031, p = 0.029) and multi-organ involvement (p = 0.026, p = 0.006) correlated significantly with COVID-19 associated death. Pulmonary microthrombi showed limited statistical correlation, while tissue necrosis, gross pulmonary embolism, and bacterial superinfection did not differentiate the 2 study groups. Chest imaging at hospital admission did not differ either.
    Conclusions: Extensive pulmonary endotheliitis and multi-organ involvement are characteristic autopsy features in fatal CO-VID-19 associated deaths. Thromboembolic and ischemic events and bacterial superinfections occur frequently in SARS-CoV-2 infection independently of outcome.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Autopsy ; COVID-19/complications ; COVID-19/mortality ; COVID-19/pathology ; Cause of Death ; Cohort Studies ; Endothelium, Vascular/pathology ; Female ; Humans ; Male ; Middle Aged ; Multiple Organ Failure/mortality ; Multiple Organ Failure/pathology ; Multiple Organ Failure/virology ; Pulmonary Alveoli/pathology ; Respiratory Distress Syndrome/mortality ; Respiratory Distress Syndrome/pathology ; Respiratory Distress Syndrome/virology ; Vasculitis/mortality ; Vasculitis/pathology ; Vasculitis/virology ; Young Adult
    Language English
    Publishing date 2021-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000518914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Demystifying pulmonary vascular complications in severe coronavirus disease-19 pneumonia (COVID-19) in the light of clinico-radiologic-pathologic correlation.

    Parry, Arshed Hussain / Wani, Abdul Haseeb / Yaseen, Mudasira / Dar, Mohd Iqbal

    Thrombosis research

    2020  Volume 196, Page(s) 559–560

    MeSH term(s) COVID-19 ; Humans ; Light ; Pandemics ; Pneumonia ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.06.043
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