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  1. Article: PET/CT: challenge for nuclear cardiology.

    Schwaiger, Markus / Ziegler, Sibylle / Nekolla, Stephan G

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2005  Volume 46, Issue 10, Page(s) 1664–1678

    Abstract: This review focuses on the clinical potential of PET/CT for the characterization ... performances and speculate on future clinical applications in the field of cardiology. ... of coronary artery disease. We describe the technical challenges of combining instrumentation with very different imaging ...

    Abstract This review focuses on the clinical potential of PET/CT for the characterization of coronary artery disease. We describe the technical challenges of combining instrumentation with very different imaging performances and speculate on future clinical applications in the field of cardiology.
    MeSH term(s) Cardiology/methods ; Cardiology/trends ; Coronary Artery Disease/diagnosis ; Humans ; Image Enhancement/methods ; Nuclear Medicine/methods ; Nuclear Medicine/trends ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/trends ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/trends ; Subtraction Technique ; Tomography, X-Ray Computed/methods ; Tomography, X-Ray Computed/trends
    Language English
    Publishing date 2005-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
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  2. Article ; Online: Assessment of external radiation dose rate after 18FDG-PET/CT examination

    Hanan Aldousari / Nouf Abuhadi / Mariam Izz / Thekra Alshammari / Zainab Ali / Razan Aldaas / Abdoelrahman Hassan Ali Bakry / Ahmed Abukonna / Abdulredha Esmail

    The Egyptian Journal of Radiology and Nuclear Medicine, Vol 54, Iss 1, Pp 1-

    2023  Volume 5

    Abstract: Abstract Background F-18 FDG (fluorodeoxyglucose) PET/CT procedures are one of the most growing ... of disease progression and cure. This study was conducted to assess the external radiation dose after 18FDG-PET/CT ... the patient can be safely released after 2 h of injection in (18F-FDG) PET/CT and the radiation dose can be ...

    Abstract Abstract Background F-18 FDG (fluorodeoxyglucose) PET/CT procedures are one of the most growing studies used for patient management in oncology, cardiology, neurology, and other indications, in which the challenges meet both patients and clinicians, especially when we are looking for the presence/absence of disease progression and cure. This study was conducted to assess the external radiation dose after 18FDG-PET/CT examination. In total, 117 patients were enrolled in the study. Radiation exposure was measured using a calibrated RadEye SPRD-ER personal radiation detector. The measurements were taken at 0, 30, 100, 150, and 200 cm distance from the patient. The time of measurement was immediately post-injection, 30 min, 60 min after injection, and at the time of releasing the patient. Results The result showed that the mean radiation equivalent dose rate at 0 min/0 cm was 414 µSv/h, at 30 min/30 cm was 99.7 µSv/h, and 60 min/100 cm was 18.3 µSv/h. The radiation doses at different distances (0, 30, 100, 150, and 200 cm) were 160.9 µSv/h, 70.9 µSv/h, 12.4 µSv/h, 7 µSv/h, and 3.7 µSv/h, respectively. Conclusion In conclusion, the patient can be safely released after 2 h of injection in (18F-FDG) PET/CT and the radiation dose can be limited by increasing distance from the radiation source and also instructing them to drink much more water to enhance the process of excretions. The dose rates are low in this study; if the staff interact with multiple patients, they will not approach exposure limits. Similarly, dose rates are so low at patient release that family will not receive doses above regulatory limits.
    Keywords 18FDG-PET/CT ; Dose rate ; Radiation exposure ; Molecular imaging ; Patient safety ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 616
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: PET/CT-identified atrial hypermetabolism is an index of atrial inflammation in patients with atrial fibrillation.

    Kupusovic, J / Weber, M / Bruns, F / Kessler, L / Pesch, E / Bohnen, J / Dobrev, D / Rassaf, T / Wakili, R / Rischpler, C / Siebermair, J

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Volume 30, Issue 5, Page(s) 1761–1772

    Abstract: ... a positron emission tomography/computed tomography (PET/CT) protocol with : Methods: We included n = 75 AF and n = 75 non-AF ... patients undergoing three common PET/CT protocols (n = 25 per group) optimized for the detection ... of atrial fibrillation (AF), the identification of atrial inflammation remains challenging. We aimed to establish ...

    Abstract Background: Although atrial inflammation has been implicated in the pathophysiology of atrial fibrillation (AF), the identification of atrial inflammation remains challenging. We aimed to establish a positron emission tomography/computed tomography (PET/CT) protocol with
    Methods: We included n = 75 AF and n = 75 non-AF patients undergoing three common PET/CT protocols (n = 25 per group) optimized for the detection of (a) inflammation and (b) malignancy in predefined fasting protocols, and (c) cardiac viability allowing for maximized glucose uptake.
    Results: Differences of visual atrial uptake in AF vs non-AF patients were observed in fasting (inflammation [13/25 vs 0/25] and malignancy [10/25 vs 0/25]) protocols while viability protocols showed non-specific uptake in both the groups. In the inflammation protocol, AF patients showed higher uptake in the right atrium [(SUVmax: 2.5 ± .7 vs 2.0 ± .7, P = .01), atrial appendage (SUVmax: 2.4 ± .7 vs 2.0 ± .6, P = .03), and epicardial adipose tissue (SUVmax: 1.4 ± .5 vs 1.1 ± .4, P = .04)]. Malignancy and viability protocols failed to differentiate between AF and non-AF.
    Conclusion: Glucose uptake suppression protocols appear suitable in detecting differential atrial
    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography/methods ; Atrial Fibrillation/diagnostic imaging ; Fluorodeoxyglucose F18 ; Radiopharmaceuticals ; Heart Atria/diagnostic imaging ; Inflammation/diagnostic imaging ; Glucose ; Neoplasms ; Positron-Emission Tomography
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-023-03248-w
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  4. Article ; Online: The prevalence of image degradation due to motion in rest-stress rubidium-82 imaging on a SiPM PET-CT system.

    Armstrong, Ian S / Memmott, Matthew J / Hayden, Charles / Arumugam, Parthiban

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2021  Volume 29, Issue 4, Page(s) 1596–1606

    Abstract: ... of motion blurring in routine cardiac PET is not fully appreciated due to challenges identifying subtle ... Background: Motion of the heart is known to affect image quality in cardiac PET. The prevalence ...

    Abstract Background: Motion of the heart is known to affect image quality in cardiac PET. The prevalence of motion blurring in routine cardiac PET is not fully appreciated due to challenges identifying subtle motion artefacts. This study utilizes a recent prototype Data-Driven Motion Correction (DDMC) algorithm to generate corrected images that are compared with non-corrected images to identify visual differences in relative rubidium-82 perfusion images due to motion.
    Methods: 300 stress and 300 rest static images were reconstructed with DDMC and without correction (NMC). The 600 DDMC/NMC image pairs were assigned Visual Difference Score (VDS). The number of non-diagnostic images were noted. A "Dwell Fraction" (DF) was derived from the data to quantify motion and predict image degradation.
    Results: Motion degradation (VDS = 1 or 2) was evident in 58% of stress images and 33% of rest images. Seven NMC images were non-diagnostic-these originated from six studies giving a 2% rate of non-diagnostic studies due to motion. The DF metric was able to effectively predict image degradation. The DDMC heart identification and tracking was successful in all images.
    Conclusion: Motion degradation is present in almost half of all relative perfusion images. The DDMC algorithm is a robust tool for predicting, assessing and correcting image degradation.
    MeSH term(s) Artifacts ; Humans ; Image Processing, Computer-Assisted/methods ; Movement ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Rubidium Radioisotopes
    Chemical Substances Rubidium Radioisotopes ; Rubidium-82 (9K730EL8KU)
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-021-02531-y
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  5. Article ; Online: Analytical quantification of aortic valve 18F-sodium fluoride PET uptake.

    Massera, Daniele / Doris, Mhairi K / Cadet, Sebastien / Kwiecinski, Jacek / Pawade, Tania A / Peeters, Frederique E C M / Dey, Damini / Newby, David E / Dweck, Marc R / Slomka, Piotr J

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2018  Volume 27, Issue 3, Page(s) 962–972

    Abstract: Background: Challenges to cardiac PET-CT include patient motion, prolonged image acquisition and ... for quantification of gated cardiac 18F-sodium fluoride (18F-fluoride) PET-CT imaging.: Methods: Twenty-seven ... for mean tissue-to-background ratio (TBR: Conclusion: 18F-fluoride PET quantification with FusionQuant ...

    Abstract Background: Challenges to cardiac PET-CT include patient motion, prolonged image acquisition and a reduction of counts due to gating. We compared two analytical tools, FusionQuant and OsiriX, for quantification of gated cardiac 18F-sodium fluoride (18F-fluoride) PET-CT imaging.
    Methods: Twenty-seven patients with aortic stenosis were included, 15 of whom underwent repeated imaging 4 weeks apart. Agreement between analytical tools and scan-rescan reproducibility was determined using the Bland-Altman method and Lin's concordance correlation coefficients (CCC).
    Results: Image analysis was faster with FusionQuant [median time (IQR) 7:10 (6:40-8:20) minutes] compared with OsiriX [8:30 (8:00-10:10) minutes, p = .002]. Agreement of uptake measurements between programs was excellent, CCC = 0.972 (95% CI 0.949-0.995) for mean tissue-to-background ratio (TBR
    Conclusion: 18F-fluoride PET quantification with FusionQuant and OsiriX is comparable. FusionQuant with motion correction offers advantages with respect to analysis time and reproducibility of TBR
    MeSH term(s) Aged ; Algorithms ; Aortic Valve/diagnostic imaging ; Female ; Fluorine Radioisotopes ; Humans ; Image Processing, Computer-Assisted/methods ; Male ; Middle Aged ; Motion ; Observer Variation ; Positron Emission Tomography Computed Tomography/methods ; Reproducibility of Results ; Signal-To-Noise Ratio ; Sodium Fluoride ; Software ; User-Computer Interface
    Chemical Substances Fluorine Radioisotopes ; Sodium Fluoride (8ZYQ1474W7) ; Fluorine-18 (GZ5I74KB8G)
    Language English
    Publishing date 2018-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-018-01542-6
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  6. Article ; Online: Meta-analysis of 18F-FDG PET/CT in the diagnosis of infective endocarditis.

    Mahmood, Maryam / Kendi, Ayse Tuba / Ajmal, Saira / Farid, Saira / O'Horo, John C / Chareonthaitawee, Panithaya / Baddour, Larry M / Sohail, M Rizwan

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2017  Volume 26, Issue 3, Page(s) 922–935

    Abstract: ... the accuracy of PET/CT for the evaluation of possible IE.: Results: We identified 13 studies involving 537 ... patients that were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of IE was ... 76.8% (95% CI 71.8-81.4%; Q = 39.9, P < 0.01; I: Conclusion: PET/CT is a useful adjunctive ...

    Abstract Background: The current diagnosis of infective endocarditis (IE) is based on the modified Duke criteria, which has approximately 80% sensitivity for the diagnosis of native valve endocarditis (NVE), with lower sensitivity for the diagnosis of prosthetic valve endocarditis (PVE) and culture-negative endocarditis. There is preliminary evidence that
    Methods: PubMed, Embase, Cochrane library, CINAHL, Web of Knowledge, and www.clinicaltrials.gov were searched from January 1990 to April 2017 for studies evaluating the accuracy of PET/CT for the evaluation of possible IE.
    Results: We identified 13 studies involving 537 patients that were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of IE was 76.8% (95% CI 71.8-81.4%; Q = 39.9, P < 0.01; I
    Conclusion: PET/CT is a useful adjunctive diagnostic tool in the evaluation of diagnostically challenging cases of IE, particularly in prosthetic valve endocarditis. It also has the potential to detect clinically relevant extracardiac foci of infection, malignancy, and other sources of inflammation leading to more appropriate treatment regimens and surgical intervention.
    MeSH term(s) Endocarditis/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals ; Sensitivity and Specificity
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2017-10-30
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-017-1092-8
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  7. Article ; Online: Analysis of partial volume correction on quantification and regional heterogeneity in cardiac PET.

    Turco, A / Nuyts, J / Duchenne, J / Gheysens, O / Voigt, J U / Claus, P / Vunckx, K

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2017  Volume 27, Issue 1, Page(s) 62–70

    Abstract: Background: The partial volume correction (PVC) of cardiac PET datasets using anatomical side ... was evaluated as a means to perform PVC. Anatomical priors based on a high-resolution CT are compared ... information during reconstruction is appealing but not straightforward. Other techniques, which do not make ...

    Abstract Background: The partial volume correction (PVC) of cardiac PET datasets using anatomical side information during reconstruction is appealing but not straightforward. Other techniques, which do not make use of additional anatomical information, could be equally effective in improving the reconstructed myocardial activity.
    Methods: Resolution modeling in combination with different noise suppressing priors was evaluated as a means to perform PVC. Anatomical priors based on a high-resolution CT are compared to non-anatomical, edge-preserving priors (relative difference and total variation prior). The study is conducted on ex vivo datasets from ovine hearts. A simulation study additionally clarifies the relationship between prior effectiveness and myocardial wall thickness.
    Results: Simple resolution modeling during data reconstruction resulted in over- and underestimation of activity, which hampers the absolute left ventricular quantification when compared to the ground truth. Both the edge-preserving and the anatomy-based PVC techniques improve the absolute quantification, with comparable results (Student t-test, P = .17). The relative tracer distribution was preserved with any reconstruction technique (repeated ANOVA, P = .98).
    Conclusions: The use of edge-preserving priors emerged as optimal choice for quantification of tracer uptake in the left ventricular wall of the available datasets. Anatomical priors visually outperformed edge-preserving priors when the thinnest structures were of interest.
    MeSH term(s) Algorithms ; Animals ; Cardiac Imaging Techniques ; Computer Simulation ; Heart/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Models, Animal ; Positron-Emission Tomography ; Sheep
    Language English
    Publishing date 2017-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-016-0773-z
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  8. Article ; Online: Focal mass-like cardiac uptake on oncologic FDG PET/CT: Real lesion or atypical pattern of physiologic uptake?

    Liu, Yiyan

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2018  Volume 26, Issue 4, Page(s) 1205–1211

    Abstract: Background: Cardiac uptake on oncologic FDG PET/CT can be unpredictable. Focal or mass-like ... results: Eight patients with suspicious mass-like cardiac uptake on oncologic FDG PET/CT were ... PET/CT. Four patients had real cardiac lesions or metastases. Focal uptake was benign and ...

    Abstract Background: Cardiac uptake on oncologic FDG PET/CT can be unpredictable. Focal or mass-like cardiac uptake not confined to normal pattern is a real challenge for interpretation due to great variability in physiologic uptake and rarity of either primary or metastatic cardiac neoplasms.
    Methods and results: Eight patients with suspicious mass-like cardiac uptake on oncologic FDG PET/CT were retrospectively analyzed with correlation to cardiac workups including contrast CT, echocardiography, and repeat PET/CT. Four patients had real cardiac lesions or metastases. Focal uptake was benign and might represent papillary muscle in the other four. SUV
    Conclusions: Focal suspicious cardiac uptake on oncology FDG PET/CT warranted further evaluation. SUV
    MeSH term(s) Adult ; Aged ; False Positive Reactions ; Female ; Fluorodeoxyglucose F18 ; Heart Diseases/diagnostic imaging ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/secondary ; Humans ; Image Processing, Computer-Assisted ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/secondary ; Male ; Melanoma/diagnostic imaging ; Middle Aged ; Neoplasm Metastasis ; Positron Emission Tomography Computed Tomography ; Retrospective Studies
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2018-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-018-01524-8
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  9. Article ; Online: 18-FDG-PET in a patient cohort suspected for cardiac sarcoidosis: Right ventricular uptake is associated with pathological uptake in mediastinal lymph nodes.

    Tuominen, Heikki / Haarala, Atte / Tikkakoski, Antti / Kähönen, Mika / Nikus, Kjell / Sipilä, Kalle

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2018  Volume 27, Issue 1, Page(s) 109–117

    Abstract: ... consecutive cardiac FDG-PET/CT studies performed on subjects suspected of having cardiac sarcoidosis were ... systemic sarcoidosis, compared with patients with PET findings indicative of isolated cardiac disease. ... Diagnosing isolated cardiac sarcoidosis is challenging due to the low sensitivity of endomyocardial biopsy ...

    Abstract Introduction: In up to 65% of cardiac sarcoidosis patients, the disease is confined to the heart. Diagnosing isolated cardiac sarcoidosis is challenging due to the low sensitivity of endomyocardial biopsy. If cardiac sarcoidosis is part of biopsy-confirmed systemic sarcoidosis, the diagnosis can be based on cardiac imaging studies. We compared the imaging features of patients with isolated cardiac FDG uptake on positron emission tomography with those who had findings indicative of systemic sarcoidosis.
    Materials and methods: 137 consecutive cardiac FDG-PET/CT studies performed on subjects suspected of having cardiac sarcoidosis were retrospectively analyzed.
    Results: 33 patients had pathological left ventricular FDG uptake, and 12 of these also had pathological right ventricular uptake. 16/33 patients with pathological cardiac uptake had pathological extracardiac uptake. 10/12 patients with both LV- and RV-uptake patterns had extracardiac uptake compared to 6/21 of those with pathological LV uptake without RV uptake. SUVmax values in the myocardium were higher among patients with abnormal extracardiac uptake. The presence of extracardiac uptake was the only imaging-related factor that could predict a biopsy indicative of sarcoidosis.
    Conclusion: Right ventricular involvement seems to be more common in patients who also have findings suggestive of suspected systemic sarcoidosis, compared with patients with PET findings indicative of isolated cardiac disease.
    MeSH term(s) Adult ; Aged ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/metabolism ; Cohort Studies ; Female ; Fluorodeoxyglucose F18/pharmacokinetics ; Heart Ventricles/metabolism ; Humans ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Male ; Mediastinum ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals/pharmacokinetics ; Sarcoidosis/diagnostic imaging ; Sarcoidosis/metabolism
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2018-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-018-1291-y
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  10. Article: Clinical myocardial perfusion PET/CT.

    Di Carli, Marcelo F / Dorbala, Sharmila / Meserve, Jolene / El Fakhri, Georges / Sitek, Arkadiusz / Moore, Stephen C

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2007  Volume 48, Issue 5, Page(s) 783–793

    Abstract: The field of nuclear cardiology is witnessing growing interest in the use of cardiac PET ... Although the introduction of hybrid PET/CT technology offers the exciting possibility of assessing the extent of anatomic ... there are technical challenges in the implementation of CT-based transmission imaging for attenuation ...

    Abstract The field of nuclear cardiology is witnessing growing interest in the use of cardiac PET for the evaluation of patients with coronary artery disease (CAD). The available evidence suggests that myocardial perfusion PET provides an accurate means for diagnosing obstructive CAD, which appears superior to SPECT especially in the obese and in those undergoing pharmacologic stress. The ability to record changes in left ventricular function from rest to peak stress and to quantify myocardial perfusion (in mL/min/g of tissue) provides an added advantage over SPECT for evaluating multivessel CAD. There is growing and consistent evidence that gated myocardial perfusion PET also provides clinically useful risk stratification. Although the introduction of hybrid PET/CT technology offers the exciting possibility of assessing the extent of anatomic CAD (CT coronary angiography) and its functional consequences (ischemic burden) in the same setting, there are technical challenges in the implementation of CT-based transmission imaging for attenuation correction. Nonetheless, this integrated platform for assessing anatomy and biology offers a great potential for translating advances in molecularly targeted imaging into humans.
    MeSH term(s) Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Humans ; Image Enhancement/methods ; Positron-Emission Tomography/methods ; Subtraction Technique ; Tomography, X-Ray Computed/methods ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/etiology
    Language English
    Publishing date 2007-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
    DOI 10.2967/jnumed.106.032789
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