Article ; Online: Serum levels of magnesium in sudden cardiac deaths among people with schizophrenia: hit or miss?
2012 Volume 70, Issue 10, Page(s) 814–816
Abstract: ... low levels of serum Mg are considered to be at high risk for sudden cardiac death. As low serum Mg is ... Understanding the mechanisms behind sudden cardiac death in individuals with schizophrenia is a key ... Schizophrenia is a devastating mental disorder, affecting cognitive, emotional, and behavioral ...
| Abstract | Schizophrenia is a devastating mental disorder, affecting cognitive, emotional, and behavioral conditions, ability to work, social functioning, family stability and self-esteem of the patient. People with schizophrenia show a two to three-fold increased risk to die prematurely than those without schizophrenia. Understanding the mechanisms behind sudden cardiac death in individuals with schizophrenia is a key to prevention. Although different mechanisms may be related, there are clear indications that cardiac abnormalities play a potential role. Some antipsychotics may be associated with cardiovascular adverse events, e.g., QT interval prolongation, metabolic dysfunction, blood pressure and heart rate alterations. Magnesium (Mg) abnormalities may lead to various morphological and functional dysfunctions of the heart and low levels of serum Mg are considered to be at high risk for sudden cardiac death. As low serum Mg is associated with detrimental effects on the heart and that antipsychotic-treated schizophrenia patients frequently affect the heart rate, possibly, these factors together must change the normal functioning of the heart and consequently being able to culminate in a catastrophic event. |
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| MeSH term(s) | Antipsychotic Agents/adverse effects ; Arrhythmias, Cardiac/chemically induced ; Biomarkers/blood ; Death, Sudden, Cardiac/etiology ; Humans ; Long QT Syndrome/chemically induced ; Magnesium/blood ; Risk Factors ; Schizophrenia/blood ; Schizophrenia/complications ; Schizophrenia/drug therapy |
| Chemical Substances | Antipsychotic Agents ; Biomarkers ; Magnesium (I38ZP9992A) |
| Language | English |
| Publishing date | 2012-09-27 |
| Publishing country | Brazil |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 418916-4 |
| ISSN | 1678-4227 ; 0004-282X |
| ISSN (online) | 1678-4227 |
| ISSN | 0004-282X |
| DOI | 10.1590/s0004-282x2012001000011 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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