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  1. Article: WITHDRAWN: Convalescent plasma, an apheresis research project targeting and motivating the fully recovered COVID 19 patients: A rousing message of clinical benefit to both donors and recipients alike.

    Seghatchian, J / Lanza, F

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2020  , Page(s) 102792

    Abstract: ... withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com ...

    Abstract The Publisher regrets that this article is an accidental duplication of an article that has already been published, https://doi.org/10.1016/j.transci.2020.102794. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2020.102792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Convalescent plasma, an apheresis research project targeting and motivating the fully recovered COVID 19 patients: A rousing message of clinical benefit to both donors and recipients alike.

    Seghatchian, J / Lanza, F

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2020  Volume 59, Issue 3, Page(s) 102794

    MeSH term(s) Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/isolation & purification ; Antibodies, Viral/therapeutic use ; Anticoagulants/therapeutic use ; Betacoronavirus/immunology ; Blood Donors/psychology ; Blood Preservation ; Blood Specimen Collection ; COVID-19 ; Convalescence ; Coronavirus Infections/blood ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Donor Selection ; Humans ; Immunization, Passive ; Immunocompromised Host ; Male ; Motivation ; Pandemics/prevention & control ; Plasma ; Plasma Exchange ; Plasmapheresis/methods ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; RNA, Viral/blood ; SARS-CoV-2 ; Thrombophilia/drug therapy ; Thrombophilia/etiology ; Thrombophilia/therapy ; Thrombosis/prevention & control ; Total Quality Management ; Volunteers
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Anticoagulants ; RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2020.102794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: WITHDRAWN: Convalescent Plasma, an Apheresis Research Project Targeting and Motivating the Fully Recovered COVID 19 Patients: A Rousing Message of Clinical Benefit To Both Donors and Recipients Alike

    Seghatchian, J. / Lanza, F.

    Transfus Apher Sci

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #657843
    Database COVID19

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  4. Article ; Online: Convalescent Plasma, an Apheresis Research Project Targeting and Motivating the Fully Recovered COVID 19 Patients: A Rousing Message of Clinical Benefit To Both Donors and Recipients Alike

    Seghatchian, J / Lanza, F

    Transfus Apher Sci

    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1016/j.transci.2020.102794
    Database COVID19

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  5. Article ; Online: Convalescent plasma, an apheresis research project targeting and motivating the fully recovered COVID 19 patients

    Seghatchian, J. / Lanza, F.

    Transfusion and Apheresis Science

    A rousing message of clinical benefit to both donors and recipients alike

    2020  Volume 59, Issue 3, Page(s) 102794

    Keywords Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2020.102794
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Convalescent plasma, an apheresis research project targeting and motivating the fully recovered COVID 19 patients

    Seghatchian, J. / Lanza, F.

    A rousing message of clinical benefit to both donors and recipients alike

    2020  

    Abstract: ... of using fully recovered COVID 19 Heroes, that is, brave volunteers, as the source of antibodies in plasma ... targeted to male donors, who consist of about 75 % of the COVID-19 population and who are able to undergo ... in critically ill COVID 19 patients and as a preventative measure, in those at potential risk of infection as no ...

    Abstract This concise manuscript aims to make suggestions for a small step forward in both preventative and therapeutic measures against the Coronavirus disease 2019 (COVID 19) pandemic. This targeted strategy consists of using fully recovered COVID 19 Heroes, that is, brave volunteers, as the source of antibodies in plasma collected by plasmapheresis or affinity column- derived antibodies, both are sterilised and pathogen inactivated for substitution therapy for use in those populations in need of antibody. This include for use in critically ill COVID 19 patients and as a preventative measure, in those at potential risk of infection as no vaccine is yet available. This would be a small step forward, while we are waiting to produce an effective, validated vaccine and witnessing increasing demands for testing and self-isolation which are the two most effective current strategies. In line with this concept, some methodological aspects of the use of the UVC sterilization of FFP/ cryoprecipitate-depleted FFP or immunoglobulins containing neutralizing antibodies for clinical use against COVID-19 are highlighted. The plasmapheresis procedure is, of course, particularly targeted to male donors, who consist of about 75 % of the COVID-19 population and who are able to undergo multiple double, or even triple plasmapheresis procedures. Moreover, as some of these donors have already been in an induced-hypercoagulable state and prone to thrombosis and DVT, this strategy will be partially aimed at improving their health with the use of citrate based anticoagulants and removal of high molecular weight viscous components which contribute to the untoward clinical effects of DVT. Repeated targeted plasmapheresis or plasma exchange of selected COVID-19 positive individuals would undoubtedly lower their state of hypercoagulability and normalize their hypercoagulability. The recipients of such a derived FFP-product would benefit from the two to 3 doses of viral inactivated antibodies, which could neutralize the viral antigens even at very low concentration if present in the early stage. So, this practice would be a double-edged sword with benefits for both donors and recipients.
    Keywords Affinity column prepared immunoglobulins ; Convalescent plasma preparation ; COVID19 antibodies ; Cryoppt- depleted plasma sup ; Pathogen inactivation ; Plasmapheresis FFP ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: WITHDRAWN

    Seghatchian, J. / Lanza, F.

    Transfusion and Apheresis Science

    Convalescent Plasma, an Apheresis Research Project Targeting and Motivating the Fully Recovered COVID 19 Patients: A Rousing Message of Clinical Benefit To Both Donors and Recipients Alike

    2020  , Page(s) 102792

    Keywords Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2020.102792
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

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