Article: Soluble Spike DNA Vaccine Provides Long-Term Protective Immunity against SARS-CoV-2 in Mice and Nonhuman Primates.
2021 Volume 9, Issue 4
Abstract: ... soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19. In mice, immunization with GX-19 elicited ... in a dose-dependent manner. GX-19-vaccinated nonhuman primates seroconverted rapidly and exhibited ... The unprecedented and rapid spread of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2 ...
| Abstract | The unprecedented and rapid spread of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) has motivated the need for a rapidly producible and scalable vaccine. Here, we developed a synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19. In mice, immunization with GX-19 elicited not only S-specific systemic and pulmonary antibody responses but also Th1-biased T cell responses in a dose-dependent manner. GX-19-vaccinated nonhuman primates seroconverted rapidly and exhibited a detectable neutralizing antibody response as well as multifunctional CD4+ and CD8+ T cell responses. Notably, when the immunized nonhuman primates were challenged at 10 weeks after the last vaccination with GX-19, they had reduced viral loads in contrast to non-vaccinated primates as a control. These findings indicate that GX-19 vaccination provides a durable protective immune response and also support further development of GX-19 as a vaccine candidate for SARS-CoV-2. |
|---|---|
| Language | English |
| Publishing date | 2021-03-24 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2703319-3 |
| ISSN | 2076-393X |
| ISSN | 2076-393X |
| DOI | 10.3390/vaccines9040307 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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