Article: Optimizing Anti-Viral Vaccine Responses: Input from a Non-Specialist.
Antibiotics (Basel, Switzerland)
2020 Volume 9, Issue 5
Abstract: ... responses to emerging RNA viruses. Here, a vaccine non-specialist suggests how this might be done. I propose ... pathogen, evolve its phage homolog to bind antibodies neutralizing for the viral pathogen. Vaccinate ... of comparison is feasibility in achieving what we need: a safe, mass-produced, emerging virus-targeted vaccine ...
| Abstract | Recently, the research community has had a real-world look at reasons for improving vaccine responses to emerging RNA viruses. Here, a vaccine non-specialist suggests how this might be done. I propose two alternative options and compare the primary alternative option with current practice. The basis of comparison is feasibility in achieving what we need: a safe, mass-produced, emerging virus-targeted vaccine on 2-4 week notice. The primary option is the following. (1) Start with a platform based on live viruses that infect bacteria, but not humans (bacteriophages, or phages). (2) Isolate phages (to be called pathogen homologs) that resemble and provide antigenic context for membrane-covered, pathogenic RNA viruses; coronavirus-phage homologs will probably be found if the search is correctly done. (3) Upon isolating a viral pathogen, evolve its phage homolog to bind antibodies neutralizing for the viral pathogen. Vaccinate with the evolved phage homolog by generating a local, non-hazardous infection with the phage host and then curing the infection by propagating the phage in the artificially infecting bacterial host. I discuss how this alternative option has the potential to provide what is needed after appropriate platforms are built. |
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| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-15 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2681345-2 |
| ISSN | 2079-6382 |
| ISSN | 2079-6382 |
| DOI | 10.3390/antibiotics9050255 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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