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Artikel: Neonatal seizures: diagnosis and management.

Seshia, Shashikant Subramani / Huntsman, Richard James / Lowry, Noel John / Seshia, Mary / Yager, Jerome Yale / Sankaran, Koravangattu

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2011 Band 13, Heft 2, Seite(n) 81–100

Abstract: ... of outcome. Management is based on uncontrolled studies and expert opinions. Information on neonatal seizures ... pyridoxal phosphate, folinic acid and biotin should be considered early, if seizures are intractable. The management ... monitoring, is crucial for management. Causes are often multi-factorial, specific to country/region, and ...

Abstract	The recognition of epileptic seizures in newborns is challenging as neonates exhibit a variety of paroxysmal motor phenomena, some epileptic but others not. The distinction, frequently requiring video-EEG monitoring, is crucial for management. Causes are often multi-factorial, specific to country/region, and change over time. Hypoxia-ischemia and infection are still common in both developed and developing countries. Venous and arterial strokes are being increasingly recognized. Treatable conditions, including inborn errors of metabolism, must be anticipated and considered early in the course. Etiology is the principal determinant of outcome. Management is based on uncontrolled studies and expert opinions. Information on neonatal seizures is reviewed, and suggestions for management provided. Phenobarbital remains the first anti-epileptic drug of choice, worldwide. Pharmacogenetic information and hepatic or renal dysfunction will influence doses of all drugs. The toxicity of excipients present in intravenous medicines should be kept in mind, especially when infusions are given to critically ill neonates. Therapeutic trials with pyridoxine or ideally pyridoxal phosphate, folinic acid and biotin should be considered early, if seizures are intractable. The management of electrographic seizures without clinical seizures needs critical study. When anti-epileptic drug treatment is required, maintenance should be for a short duration if seizures are of an acute symptomatic nature.
Mesh-Begriff(e)	Anticonvulsants/therapeutic use ; Diagnosis, Differential ; Electroencephalography ; Humans ; Infant, Newborn ; Seizures/diagnosis ; Seizures/drug therapy ; Seizures/etiology
Chemische Substanzen	Anticonvulsants
Sprache	Englisch
Erscheinungsdatum	2011-02
Erscheinungsland	China
Dokumenttyp	Journal Article ; Review
ISSN	1008-8830
ISSN	1008-8830
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Neonatal seizures: How should we make a diagnosis and management?

Yamanouchi, Hideo

Pediatrics international : official journal of the Japan Pediatric Society

2020 Band 62, Heft 9, Seite(n) 1016

Mesh-Begriff(e)	Anticonvulsants/therapeutic use ; Electroencephalography ; Epilepsy/diagnosis ; Epilepsy/drug therapy ; Humans ; Infant, Newborn ; Seizures/diagnosis ; Seizures/drug therapy
Chemische Substanzen	Anticonvulsants
Sprache	Englisch
Erscheinungsdatum	2020-07-08
Erscheinungsland	Australia
Dokumenttyp	Editorial
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.14336
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Neonatal Seizures: Diagnosis, Etiologies, and Management.

Ziobro, Julie / Shellhaas, Renée A

Seminars in neurology

2020 Band 40, Heft 2, Seite(n) 246–256

Abstract: Neonates are exquisitely susceptible to seizures due to several physiologic factors and combination ... symptomatic seizures, though additional studies are needed to understand optimal seizure control metrics and ... seizure etiology. Early identification and treatment are likely important for long-term outcomes in acute ...

Abstract	Neonates are exquisitely susceptible to seizures due to several physiologic factors and combination of risks that are uniquely associated with gestation, delivery, and the immediate postnatal period. Neonatal seizures can be challenging to identify; therefore, it is imperative that clinicians have a high degree of suspicion for seizures based on the clinical history or the presence of encephalopathy with or without paroxysmal abnormal movements. Acute symptomatic neonatal seizures are due to an acute brain injury, whereas neonatal-onset epilepsy may be related to underlying structural, metabolic, or genetic disorders. Though initial, acute treatment is similar, long-term treatment and prognosis varies greatly based on underlying seizure etiology. Early identification and treatment are likely important for long-term outcomes in acute symptomatic seizures, though additional studies are needed to understand optimal seizure control metrics and the ideal duration of treatment. Advances in genetic medicine are increasingly expanding our understanding of neonatal-onset epilepsies and will continue to open doors for personalized medicine to optimize outcomes in this fragile population.
Mesh-Begriff(e)	Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; Seizures/diagnosis ; Seizures/etiology ; Seizures/therapy
Sprache	Englisch
Erscheinungsdatum	2020-03-06
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603165-1
ISSN	1098-9021 ; 0271-8235
ISSN (online)	1098-9021
ISSN	0271-8235
DOI	10.1055/s-0040-1702943
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch: Diagnosis and management of neonatal seizures

Mizrahi, Eli M. / Kellaway, Peter

1998

Verfasserangabe	Eli M. Mizrahi ; Peter Kellaway
Schlagwörter	Seizures / in infancy & childhood ; Seizures / diagnosis ; Seizures / therapy ; Infant, Newborn, Diseases / diagnosis ; Infant, Newborn, Diseases / therapy ; Electroencephalography ; Neugeborenes ; Anfallsleiden
Schlagwörter	Anfallskrankheit ; Neugeborene
Sprache	Englisch
Umfang	IX, 181 S. : Ill., graph. Darst.
Verlag	Lippincott-Raven
Erscheinungsort	Philadelphia u.a.
Erscheinungsland	Vereinigte Staaten
Dokumenttyp	Buch
HBZ-ID	HT008813186
ISBN	0-7817-0296-8 ; 978-0-7817-0296-6
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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1998 A 5005	bestellbar zur Ausleihe	Magazin

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Artikel: Neonatal Seizures: Diagnosis, Etiologies, and Management

Ziobro, Julie / Shellhaas, Renée A.

Seminars in Neurology

(Pediatric Neurology)

2020 Band 40, Heft 02, Seite(n) 246–256

Serientitel	Pediatric Neurology
Abstract	Neonates are exquisitely susceptible to seizures due to several physiologic factors and combination of risks that are uniquely associated with gestation, delivery, and the immediate postnatal period. Neonatal seizures can be challenging to identify; therefore, it is imperative that clinicians have a high degree of suspicion for seizures based on the clinical history or the presence of encephalopathy with or without paroxysmal abnormal movements. Acute symptomatic neonatal seizures are due to an acute brain injury, whereas neonatal-onset epilepsy may be related to underlying structural, metabolic, or genetic disorders. Though initial, acute treatment is similar, long-term treatment and prognosis varies greatly based on underlying seizure etiology. Early identification and treatment are likely important for long-term outcomes in acute symptomatic seizures, though additional studies are needed to understand optimal seizure control metrics and the ideal duration of treatment. Advances in genetic medicine are increasingly expanding our understanding of neonatal-onset epilepsies and will continue to open doors for personalized medicine to optimize outcomes in this fragile population.
Schlagwörter	epilepsy ; neonate ; encephalopathy ; seizure
Sprache	Englisch
Erscheinungsdatum	2020-03-06
Verlag	Thieme Medical Publishers
Erscheinungsort	Stuttgart ; New York
Dokumenttyp	Artikel
ZDB-ID	603165-1
ISSN	1098-9021 ; 0271-8235
ISSN (online)	1098-9021
ISSN	0271-8235
DOI	10.1055/s-0040-1702943
Datenquelle	Thieme Verlag

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Artikel: Questions and Controversies in Neonatal Seizures.

Cappellari, Alberto M / Palumbo, Sarah / Margiotta, Stefania

Children (Basel, Switzerland)

2023 Band 11, Heft 1

Abstract: Neonatal seizures are relatively common, but their diagnosis and management remain challenging ... still many issues on the diagnosis and treatment of neonatal seizures, including the meaning or ... treatment. Recent classification system of seizures and epilepsies in the newborn, as well as treatment ...

Abstract	Neonatal seizures are relatively common, but their diagnosis and management remain challenging. We reviewed the scientific literature on neonatal seizures from July 1973 to November 2023. Several parameters were considered, including pathophysiology, diagnostic criteria, electroencephalographic findings and treatment. Recent classification system of seizures and epilepsies in the newborn, as well as treatment recommendations of neonatal seizures, have been proposed. Nonetheless, the approach to neonatal seizures varies among clinicians and centres, including detection, investigation, treatment and follow-up of patients. There are still many issues on the diagnosis and treatment of neonatal seizures, including the meaning or relevance of some electroencephalographic findings, the precise estimation of the seizure burden, the limited efficacy and side effects risk of antiseizure medications, and the best measures to establish the outcome.
Sprache	Englisch
Erscheinungsdatum	2023-12-29
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children11010040
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The role of metabolic diseases in neonatal convulsions.

Samanci, S / Celik, M / Akdeniz, O / Deger, I / Özgün, N / Kanar, B / Tüzün, H

European review for medical and pharmacological sciences

2023 Band 27, Heft 4, Seite(n) 1384–1390

Abstract: ... to the immature brain and constitute a neurological emergency, necessitating urgent diagnosis and management ... Objective: The neonatal period is the most vulnerable time for the development of seizures ... particularly in the first weeks after birth. These seizures often signify serious malfunction or damage ...

Abstract	Objective: The neonatal period is the most vulnerable time for the development of seizures, particularly in the first weeks after birth. These seizures often signify serious malfunction or damage to the immature brain and constitute a neurological emergency, necessitating urgent diagnosis and management. This study was performed to identify the etiology of convulsions during the neonatal period and to determine the rate of congenital metabolic disease. Patients and methods: A total of 107 term and preterm infants 0-28 days old who were treated and followed-up in the neonatal intensive care unit of our hospital between January 2014 and December 2019 were analyzed retrospectively based on data obtained by scanning the hospital information system and patient files. Results: The study population included 54.2% male infants, and 35.5% of infants were born by caesarean section. Birth weight was 3,016 ± 560 (1,300-4,250) g, mean length of gestation was 38 (29-41) weeks, and mean maternal age was 27.4 ± 6.1 (16-42) years. Of the infants, 26 (24.3%) were preterm and 81 (75.7%) were term deliveries. Examination of family history revealed 21 (19.6%) cases with consanguineous parents and 14 (13.1%) cases with a family history of epilepsy. Hypoxic ischemic encephalopathy was the most common etiology of the seizures (34.5%). Burst suppression was detected on amplitude integrated electroencephalography in 21 (56.7%) monitored cases. Although subtle convulsions were most common, myoclonic, clonic, tonic and unclassified convulsions were also observed. The convulsions appeared during the first week of life in 66.3% of cases and during the second week or later in 33.7%. Fourteen (13.1%) patients examined by metabolic screening due to suspected congenital metabolic disease had a different congenital metabolic diagnosis. Conclusions: Although hypoxic ischemic encephalopathy was the most common cause of neonatal convulsions in our study, congenital metabolic diseases with autosomal recessive inheritance were detected at a high rate.
Mesh-Begriff(e)	Infant, Newborn ; Pregnancy ; Infant ; Humans ; Male ; Female ; Young Adult ; Adult ; Cesarean Section ; Hypoxia-Ischemia, Brain ; Retrospective Studies ; Infant, Premature ; Seizures ; Epilepsy ; Metabolic Diseases ; Infant, Newborn, Diseases
Sprache	Englisch
Erscheinungsdatum	2023-03-05
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202302_31375
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Neonatal Seizures Revisited.

Kaminiów, Konrad / Kozak, Sylwia / Paprocka, Justyna

Children (Basel, Switzerland)

2021 Band 8, Heft 2

Abstract: ... pathomechanism, clinical symptoms and guidelines for the management of neonates with acute symptomatic seizures. ... Seizures are the most common neurological disorder in newborns and are most prevalent ... in acute brain damage and can manifest as seizures in neonates include hypoxic-ischemic encephalopathy (HIE ...

Abstract	Seizures are the most common neurological disorder in newborns and are most prevalent in the neonatal period. They are mostly caused by severe disorders of the central nervous system (CNS). However, they can also be a sign of the immaturity of the infant's brain, which is characterized by the presence of specific factors that increase excitation and reduce inhibition. The most common disorders which result in acute brain damage and can manifest as seizures in neonates include hypoxic-ischemic encephalopathy (HIE), ischemic stroke, intracranial hemorrhage, infections of the CNS as well as electrolyte and biochemical disturbances. The therapeutic management of neonates and the prognosis are different depending on the etiology of the disorders that cause seizures which can lead to death or disability. Therefore, establishing a prompt diagnosis and implementing appropriate treatment are significant, as they can limit adverse long-term effects and improve outcomes. In this review paper, we present the latest reports on the etiology, pathomechanism, clinical symptoms and guidelines for the management of neonates with acute symptomatic seizures.
Sprache	Englisch
Erscheinungsdatum	2021-02-18
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children8020155
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Congenital neurosyphilis presenting as neonatal sepsis.

Iskandar, Wedi / Permatagalih, Vidi / Primadi, Aris / Gamayani, Uni

Journal of infection in developing countries

2022 Band 16, Heft 6, Seite(n) 1113–1117

Abstract: ... Pallidum Hemagglutination Assay TPHA tests titters were 1:16 and 1:1,280, respectively. The diagnosis ... with early management of sepsis. Blood culture was sterile later on. Then, the infant was administered ... at admission was respiratory failure and neonatal sepsis. The infant was mechanically ventilated and treated ...

Abstract	Introduction: Congenital syphilis involves any organs with various symptoms, including neurological signs. Neurosyphilis is a severe syphilis complication that can develop at any stage of illness. Case presentation: A 2,520 g male infant was spontaneously born at term from an untreated syphilis mother. Physical examination revealed decreased consciousness, respiratory distress, seizure, but without neurologic abnormality sign. The serum and cerebrospinal fluid Venereal Disease Research Laboratory and Treponemal Pallidum Hemagglutination Assay TPHA tests titters were 1:16 and 1:1,280, respectively. The diagnosis at admission was respiratory failure and neonatal sepsis. The infant was mechanically ventilated and treated with early management of sepsis. Blood culture was sterile later on. Then, the infant was administered intramuscular benzathine penicillin G (50,000 units/kg/dose) for a total of three weeks. The infant's condition was improved during the treatment. Conclusions: There are many challenges associated with screening and monitoring neurosyphilis in congenital syphilis. Congenital syphilis presenting as sepsis is easily misdiagnosed as bacterial sepsis.
Mesh-Begriff(e)	Humans ; Infant, Newborn ; Male ; Neonatal Sepsis/diagnosis ; Neurosyphilis/complications ; Neurosyphilis/diagnosis ; Neurosyphilis/drug therapy ; Syphilis ; Syphilis, Congenital/complications ; Syphilis, Congenital/diagnosis ; Syphilis, Congenital/drug therapy ; Treponema pallidum
Sprache	Englisch
Erscheinungsdatum	2022-06-30
Erscheinungsland	Italy
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.15662
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Genetic Etiologies of Neonatal Seizures.

Kaur, Shagun / Pappas, Kara

NeoReviews

2020 Band 21, Heft 10, Seite(n) e663–e672

Abstract: Neonates presenting with seizures are frequently assessed and managed by neonatologists in the NICU ... Although hypoxic-ischemic encephalopathy and infection are common underlying causes of neonatal seizures, many patients with neonatal ... with a geneticist. The categories of genetic causes of neonatal seizures include 1) structural brain malformations ...

Abstract	Neonates presenting with seizures are frequently assessed and managed by neonatologists in the NICU. Although hypoxic-ischemic encephalopathy and infection are common underlying causes of neonatal seizures, many patients with neonatal epilepsy will have an identifiable genetic etiology. Often these cases will be evaluated in collaboration with a geneticist. The categories of genetic causes of neonatal seizures include 1) structural brain malformations; 2) inborn errors of metabolism; 3) syndromic; and 4) nonsyndromic, single gene. Evaluation of these patients involves a comprehensive history and examination, followed by appropriate investigations and diagnostic genetic testing. Components of the diagnostic process will vary based on the clinical suspicion and differential diagnoses. In certain cases, syndromic surveillance for evaluation of other congenital anomalies may be recommended. Determination of the underlying genetic diagnosis, when present, will have important implications for treatment. Targeted therapies are currently available for specific genetic syndromes, and outcomes may improve with earlier initiation of therapy. Certain genetic diagnoses may also have guideline-based management involving screening for other manifestations of the disorder.
Mesh-Begriff(e)	Diagnosis, Differential ; Epilepsy/diagnosis ; Epilepsy/genetics ; Humans ; Hypoxia-Ischemia, Brain/diagnosis ; Infant, Newborn ; Infant, Newborn, Diseases ; Seizures/diagnosis ; Seizures/genetics
Sprache	Englisch
Erscheinungsdatum	2020-10-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1526-9906
ISSN (online)	1526-9906
DOI	10.1542/neo.21-10-e663
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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