Article ; Online: MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
2010 Volume 51, Issue 2, Page(s) 311–328
Abstract: ... to provide guidance and recommendations for human alpha-particle emitter dosimetry. ... to review those aspects of the field that are pertinent to targeted alpha-particle emitter therapy and ... Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and ...
| Abstract | The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle emitter therapy and to provide guidance and recommendations for human alpha-particle emitter dosimetry. |
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| MeSH term(s) | Alpha Particles/adverse effects ; Alpha Particles/therapeutic use ; Cell Death/radiation effects ; Cell Survival/radiation effects ; Clinical Trials as Topic ; Dose-Response Relationship, Radiation ; Female ; Humans ; Male ; Neoplasms/radiotherapy ; Neoplasms, Radiation-Induced/etiology ; Pamphlets ; Radiation-Protective Agents/therapeutic use ; Radiobiology ; Radioisotopes/adverse effects ; Radioisotopes/therapeutic use ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Relative Biological Effectiveness ; Societies, Medical | ||||||||||
| Chemical Substances | Radiation-Protective Agents ; Radioisotopes | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2010-01-15 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 80272-4 | ||||||||||
| ISSN | 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123 | ||||||||||
| ISSN (online) | 1535-5667 | ||||||||||
| ISSN | 0097-9058 ; 0161-5505 ; 0022-3123 | ||||||||||
| DOI | 10.2967/jnumed.108.058651 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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