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  1. Article ; Online: Severity of SARS-CoV-2 Omicron variant infection in heart transplant recipients.

    Hazan, Fanny / Verdonk, Constance / Coutance, Guillaume / Ferré, Valentine Marie / Marot, Stéphane / Melo, Vania Da Dilva / Legeai, Camille / Lebreton, Guillaume / Para, Marylou / Varnous, Shaida / Dorent, Richard

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2023  Volume 42, Issue 5, Page(s) 558–561

    Abstract: ... characteristics of HT recipients infected with SARS-CoV-2 during Omicron (December 1st, 2021-February 7, 2022) and ... in heart transplant (HT) recipients. In this study, we examined incidence and mortality rate of COVID-19 ... SARS-CoV-2 Omicron variant was first detected in France mid-November 2021 ...

    Abstract SARS-CoV-2 Omicron variant was first detected in France mid-November 2021 in wastewater treatment plants while cases started to increase at the beginning of December. The maximum incidence occurred in mid-January 2022. The Omicron wave spread rapidly throughout France in general population with lower case-fatality rate compared with previous waves. Little is known about infection with Omicron variant in heart transplant (HT) recipients. In this study, we examined incidence and mortality rate of COVID-19 in the general population and among 1,263 HT recipients during the period from June, 2021 to February, 2022, described characteristics of HT recipients infected with SARS-CoV-2 during Omicron (December 1st, 2021-February 7, 2022) and Delta (June 1st- November 30, 2021) periods, and compared hospital course of HT recipients with Omicron and Delta variant infection. Our findings contrast with the reported lower severity for Omicron variant infection compared with Delta variant infection in immunocompetent individuals.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; France/epidemiology ; Heart Transplantation
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2023.01.012
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  2. Article ; Online: Rapidly progressive graft vasculopathy in a heart transplant recipient with confirmed SARS-CoV-2 infection.

    MacKay, Micaela / Clewis, Madison / Khalife, Wissam

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 26, Issue 1, Page(s) e14225

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Heart Transplantation/adverse effects ; Vascular Diseases ; Transplant Recipients ; Graft Rejection
    Language English
    Publishing date 2023-12-28
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14225
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  3. Article: SARS-CoV-2 Infection in the Heart Transplant Recipient.

    Shah, Jassim Zaheen / Elbdri, Salah / Patel, Ashfaq Ahmad / Badr, Amr Mohamed Hamed

    Heart views : the official journal of the Gulf Heart Association

    2020  Volume 21, Issue 3, Page(s) 220–224

    Abstract: ... being the most common. The SARS-CoV-2 infection did not increase the risk of transplant allograft ... infection in heart transplant recipients. However, this population is at increased risk of a more severe ... in transplant recipients. However, the International Society of Heart and Lung and Transplant has issued guidance on how ...

    Abstract Review of the literature and reported case series has not reported an increased risk of SARS-CoV-2 infection in heart transplant recipients. However, this population is at increased risk of a more severe infection with increased mortality because of age and the presence of multiple comorbid conditions There is no significant difference in presenting symptoms in transplant recipients as compared to nontransplant patients, although diarrhea has been reported to be more frequent in transplant patients, a common side effect of immunosuppressive medications. Standard preventive measures have been shown to be equally protective in heart transplant recipients. Risk factors for severe disease and mortality are similar in both transplant recipients and nontransplant patients and include older age and the presence of comorbidities hypertension being the most common. The SARS-CoV-2 infection did not increase the risk of transplant allograft rejection. Currently, there are no specific treatment recommendations for SARS-CoV-2 infection in transplant recipients. However, the International Society of Heart and Lung and Transplant has issued guidance on how to modulate immunosuppressive therapy during SARS-CoV-2 infection.
    Language English
    Publishing date 2020-10-13
    Publishing country India
    Document type Case Reports
    ZDB-ID 2575257-1
    ISSN 0976-5123 ; 1995-705X
    ISSN (online) 0976-5123
    ISSN 1995-705X
    DOI 10.4103/HEARTVIEWS.HEARTVIEWS_155_20
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  4. Article ; Online: Neutralization of SARS-CoV-2 variants elicited by the combination of vaccination and natural infection in heart transplant recipients.

    Peled, Yael / Afek, Arnon / Patel, Jignesh K / Raanani, Ehud / Segev, Amit / Ram, Eilon / Atari, Nofar / Kliker, Limor / Elkader, Bayan Abd / Mandelboim, Michal

    Clinical transplantation

    2023  Volume 37, Issue 11, Page(s) e15092

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Vaccination ; Heart Transplantation/adverse effects
    Language English
    Publishing date 2023-08-11
    Publishing country Denmark
    Document type Letter
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15092
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  5. Article ; Online: SARS-CoV-2 infection in the heart transplant recipient

    Jassim Zaheen Shah / Salah Elbdri / Ashfaq Ahmad Patel / Amr Mohamed Hamed Badr

    Heart Views, Vol 21, Iss 3, Pp 220-

    2020  Volume 224

    Abstract: ... being the most common. The SARS-CoV-2 infection did not increase the risk of transplant allograft ... infection in heart transplant recipients. However, this population is at increased risk of a more severe ... in transplant recipients. However, the International Society of Heart and Lung and Transplant has issued guidance on how ...

    Abstract Review of the literature and reported case series has not reported an increased risk of SARS-CoV-2 infection in heart transplant recipients. However, this population is at increased risk of a more severe infection with increased mortality because of age and the presence of multiple comorbid conditions There is no significant difference in presenting symptoms in transplant recipients as compared to nontransplant patients, although diarrhea has been reported to be more frequent in transplant patients, a common side effect of immunosuppressive medications. Standard preventive measures have been shown to be equally protective in heart transplant recipients. Risk factors for severe disease and mortality are similar in both transplant recipients and nontransplant patients and include older age and the presence of comorbidities hypertension being the most common. The SARS-CoV-2 infection did not increase the risk of transplant allograft rejection. Currently, there are no specific treatment recommendations for SARS-CoV-2 infection in transplant recipients. However, the International Society of Heart and Lung and Transplant has issued guidance on how to modulate immunosuppressive therapy during SARS-CoV-2 infection.
    Keywords covid-19 ; heart transplant ; immunosuppressive therapy ; sars-cov-2 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: SARS-CoV-2 infection in heart transplant recipients: a systematic literature review of clinical outcomes and immunosuppression strategies.

    Ilonze, Onyedika J / Ballut, Kareem / Rao, Roopa S / Jones, Mark A / Guglin, Maya

    Heart failure reviews

    2021  Volume 27, Issue 5, Page(s) 1653–1663

    Abstract: ... We identified 74 cases of SARS-CoV-2 infection in heart transplant and heart-kidney transplant recipients ... The impact of SARS-CoV-2 infection on heart transplant recipients is unknown. Literature is limited ... immunosuppression strategies of heart transplant recipients with COVID-19 infection. A systematic review was ...

    Abstract The impact of SARS-CoV-2 infection on heart transplant recipients is unknown. Literature is limited to case reports and series. The purpose of this study is to identify the clinical features, outcomes, and immunosuppression strategies of heart transplant recipients with COVID-19 infection. A systematic review was conducted using the search term "Coronavirus" or COVID," "SARS-CoV-2," "cardiac transplantation," and "heart transplant." Case reports and retrospective studies were gathered by searching Medline/PubMed, Google Scholar, CINAHL, Cochrane CENTRAL, and Web of Science. Thirty-three articles were selected for review. We identified 74 cases of SARS-CoV-2 infection in heart transplant and heart-kidney transplant recipients. The mean age was 60.5 ± 15.8 years, and 82.4% were males with median time from transplant of 6.5 years. Commonest symptoms were fever, cough, and dyspnea, but new left ventricular (LV) dysfunction was rare. Leukocytosis, lymphopenia, elevated inflammatory markers, and bilateral ground-glass opacities were common. Mortality was high, with particularly poor survival in patients who required intensive care unit (ICU) admission and older patients. Immunosuppression involved discontinuation of antimetabolites and steroids. COVID-19 infection in heart transplant (HT) recipients presents similarly to the general population, but new onset of LV dysfunction is uncommon. Immunosuppression strategies include increase in corticosteroids and discontinuation of antimetabolites.
    MeSH term(s) Adult ; Aged ; Antimetabolites ; COVID-19 ; Female ; Heart Transplantation/adverse effects ; Humans ; Immunosuppression Therapy/adverse effects ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Transplant Recipients
    Chemical Substances Antimetabolites
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-021-10181-y
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  7. Article ; Online: Transplantation of organs from SARS-CoV-2-positive donors: Preliminary experience from Spain.

    Montiel Villalonga, Patricia / Martínez-Alpuente, Itzíar / Fernández-Ruiz, Mario / Len, Óscar / Bodro, Marta / Los-Arcos, Ibai / Moya, José / de la Calle, Braulio / Cid-Cumplido, Manuela / Sánchez-Etayo, Gerard / Ávila, Ana / Moreno-González, Gabriel / Coll, Elisabeth / Domínguez-Gil, Beatriz

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 25, Issue 1, Page(s) e14008

    Abstract: ... right heart failure. Graft losses and patient deaths were deemed unrelated to the donor SARS-CoV-2 ... received a solid organ transplant (41 kidney, 18 liver, 8 heart, and 2 combined liver-kidney) obtained ... threshold value <30). All recipients tested negative for SARS-CoV-2 and were free of coronavirus disease 2019 ...

    Abstract Background: The utilization of non-lung organs from deceased donors with a positive polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the time of donation can be lifesaving, although the safety of this policy must be assessed.
    Methods: This is a nationwide, prospective study, reporting the experience on the utilization of non-lung organs from SARS-CoV-2-positive donors between December 15, 2020 and May 31, 2022 in Spain.
    Results: A total of 69 patients received a solid organ transplant (41 kidney, 18 liver, 8 heart, and 2 combined liver-kidney) obtained from 32 donors with a positive SARS-CoV-2 PCR at the time of donation (four of them with a cycle threshold value <30). All recipients tested negative for SARS-CoV-2 and were free of coronavirus disease 2019 (COVID-19) symptoms prior to transplantation. Nasopharyngeal swab turned positive for SARS-CoV-2 PCR in 4 (5.8%) recipients at 3, 8, 11, and 20 days after transplantation, though evidence did not support a donor-derived COVID-19. Four kidney recipients lost their grafts and two patients died: one heart recipient due to cardiogenic shock and one combined liver-kidney recipient due to lung hypertension and right heart failure. Graft losses and patient deaths were deemed unrelated to the donor SARS-CoV-2 status by the treating teams. No other adverse reactions were reported.
    Conclusions: This preliminary experience supports the safety of the use of organs other than lungs from SARS-CoV-2 PCR-positive donors, in alignment with previous series. However, the impact of SARS-CoV-2 infection upon organ quality should be established in future research.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Prospective Studies ; Spain ; Tissue Donors
    Language English
    Publishing date 2023-01-19
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14008
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  8. Article ; Online: When you need to dive in the deep end-Transplanting SARS-CoV-2 PCR+ recipients.

    Zavala, Sofia / DeLaurentis, Clare / Aaron, Justin G / Miko, Benjamin A / Fox, Alyson N / Bergelson, Michael / DeVore, Adam / Segovia, Maria Cristina / Wolfe, Cameron R / Pereira, Marcus R

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 25, Issue 5, Page(s) e14110

    Abstract: ... retrospective data of all consecutive non-lung transplant recipients who had a positive SARS-CoV-2 polymerase ... Transplantation can safely proceed in select, minimally symptomatic, non-lung recipients with a positive SARS-CoV ... 2 PCR at the time of transplant. ...

    Abstract There is an ongoing need to understand whether transplantation during acute Coronavirus disease 2019 (COVID-19) can be performed safely, especially when urgent transplant is required. We collected retrospective data of all consecutive non-lung transplant recipients who had a positive SARS-CoV-2 polymerase chain reaction (PCR) on the day of planned deceased donor organ implantation. Data were collected from two large transplant centers from 01/01/2022 to 02/01/2023. Demographics, details regarding COVID-19 infection, waitlist priority, and details regarding transplantation were obtained. A descriptive analysis was performed. A total of 12 patients were identified: 7 renal, 4 liver, and 1 heart transplant recipient. All 12 patients were vaccinated for COVID-19. Ten were asymptomatic outpatients found positive on admission and transplanted immediately. Two were in-patients with mild COVID-19 symptoms and were reactivated on the waitlist following 3 days of remdesivir when no progression to severe COVID-19 occurred. Most patients (10/12) received remdesivir posttransplant. No complications attributed to COVID-19 were noted nor were any secondary family or healthcare worker infections observed. All recipients were managed with special isolation precautions befitting their potentially infectious state. Standard induction therapy was used in all recipients. After a median follow up period of 143 days (interquartile range: 96-201 days), 3 episodes of rejection were documented, 2/7 renal recipients experienced delayed graft function, and 2/4 liver recipients required renal replacement therapy. Graft and patient survival were 100%. Transplantation can safely proceed in select, minimally symptomatic, non-lung recipients with a positive SARS-CoV-2 PCR at the time of transplant.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Transplant Recipients ; Retrospective Studies ; Organ Transplantation ; COVID-19 Testing
    Language English
    Publishing date 2023-08-01
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14110
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  9. Article: Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients.

    Zwetsloot, Peter-Paul / Smit, Wouter L / Van der Kaaij, Niels P / Szymanski, Mariusz K / Van der Meer, Manon G / Van Laake, Linda W / Troelstra, Annet / Wegdam-Blans, Marjolijn C A / Oerlemans, Marish I F J

    Biomedicines

    2023  Volume 11, Issue 8

    Abstract: ... of the recipients reported any symptoms of a viral infection. Fifty HTx recipients were screened for SARS-CoV-2 ... result.: Conclusion: Pre-operative SARS-CoV-2 screening in asymptomatic HTx recipients did not lead ... CoV-2) before heart transplantation (HTx). Due to the changing prevalence of COVID-19, the chances ...

    Abstract Introduction: From the start of the coronavirus disease 2019 (COVID-19) pandemic, international guidelines have recommended pre-operative screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before heart transplantation (HTx). Due to the changing prevalence of COVID-19, the chances of false positive results have increased. Because of increased immunity in the population and evolution of SARS-CoV-2 to current Omicron variants, associated mortality and morbidity have decreased. We set out to investigate the yield and side effects of SARS-CoV-2 screening in our center.
    Methods: We performed a retrospective cohort study in the University Medical Center Utrecht. The study period was from March 2019 to January 2023. All data from patients who underwent HTx were collected, including all pre-operative and post-operative SARS-CoV-2 tests. Furthermore, all clinical SARS-CoV-2 tests for the indication of potential HTx were screened.
    Results: In the period under study, 51 patients underwent HTx. None of the recipients reported any symptoms of a viral infection. Fifty HTx recipients were screened for SARS-CoV-2. Forty-nine out of fifty patients tested negative. One patient had a false positive result, potentially delaying the HTx procedure. There were no cancelled HTx procedures due to a true positive SARS-CoV-2 test result.
    Conclusion: Pre-operative SARS-CoV-2 screening in asymptomatic HTx recipients did not lead to any true positive cases. In 2% of the cases, screening resulted in a false positive test result. With the current Omicron variants, in combination with a low-prevalence situation, we propose to abandon pre-operative SARS-CoV-2 screening and initiate a symptom-driven approach for the general viral testing of patients who are called in for a potential HTx.
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11082103
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  10. Article ; Online: Sotrovimab in pediatric cardiac transplant recipients with SARS-CoV2 infection.

    Weber, Sven C / Danne, Friederike / Kieslich, Moritz / Krauss, Annemarie / Berger, Felix / Sallmon, Hannes

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2022  Volume 41, Issue 8, Page(s) 1124–1126

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; COVID-19 ; Child ; Heart Transplantation ; Humans ; RNA, Viral ; SARS-CoV-2 ; Transplant Recipients
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; RNA, Viral ; sotrovimab (1MTK0BPN8V)
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Letter
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2022.05.003
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