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  1. Article: Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin.

    Shao, Jin / Wang, Zhi / Yang, Tieyi / Ying, Hui / Zhang, Yan / Liu, Shuyi

    International journal of endocrinology

    2015  Volume 2015, Page(s) 967673

    Abstract: ... as a structural scaffold but also as an endocrine organ, which regulates several metabolic processes. Besides ... especially in glucose metabolism. ... In summary, skeleton has endocrine function via OCN and plays an important role in energy metabolism ...

    Abstract Skeleton was considered as a dynamic connective tissue, which was essential for mobility, calcium homeostasis, and hematopoietic niche. However more and more evidences indicate that skeleton works not only as a structural scaffold but also as an endocrine organ, which regulates several metabolic processes. Besides osteoprotegerin (OPG), sclerostin (SOST), and Dickopf (DKK) which play essential roles in bone formation, modelling, remodelling, and homeostasis, bone can also secret hormones, such as osteocalcin (OCN), which promotes proliferation of β cells, insulin secretion, and insulin sensitivity. Additionally OCN can also regulate the fat cells and male gonad endocrine activity and be regulated by insulin and the neural system. In summary, skeleton has endocrine function via OCN and plays an important role in energy metabolism, especially in glucose metabolism.
    Language English
    Publishing date 2015-03-19
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2502951-4
    ISSN 1687-8345 ; 1687-8337
    ISSN (online) 1687-8345
    ISSN 1687-8337
    DOI 10.1155/2015/967673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comment on "Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin".

    Verma, Hitesh / Garg, Rajeev

    International journal of endocrinology

    2016  Volume 2016, Page(s) 9724929

    Language English
    Publishing date 2016-09-20
    Publishing country Egypt
    Document type Journal Article ; Comment
    ZDB-ID 2502951-4
    ISSN 1687-8345 ; 1687-8337
    ISSN (online) 1687-8345
    ISSN 1687-8337
    DOI 10.1155/2016/9724929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin

    Jin Shao / Zhi Wang / Tieyi Yang / Hui Ying / Yan Zhang / Shuyi Liu

    International Journal of Endocrinology, Vol

    2015  Volume 2015

    Keywords Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin

    Jin Shao / Zhi Wang / Tieyi Yang / Hui Ying / Yan Zhang / Shuyi Liu

    International Journal of Endocrinology, Vol

    2014  Volume 2014

    Keywords Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: [Bone-derived hormones and their systemic regulation.]

    Takashi, Yuichi / Fukumoto, Seiji / Matsumoto, Toshio

    Clinical calcium

    2018  Volume 28, Issue 1, Page(s) 9–15

    Abstract: ... phosphate metabolism and osteocalcin affect glucose/energy metabolism. In addition, sclerostin, interleukin ... regulates functions of other organs. It has been reported that fibroblast growth factor 23(FGF23)regulates ... Bone has several functions such as supporting our body, protecting internal organs and contributing ...

    Abstract Bone has several functions such as supporting our body, protecting internal organs and contributing to hematopoiesis. Recently, it has been revealed that bone also works as an endocrine tissue and systemically regulates functions of other organs. It has been reported that fibroblast growth factor 23(FGF23)regulates phosphate metabolism and osteocalcin affect glucose/energy metabolism. In addition, sclerostin, interleukin-11(IL-11)and lipocalin 2 have been also found to be bone-derived humoral factors. Further investigation concerning the network systems among multiple organs via bone-derived hormones may lead to the development of new drugs.
    MeSH term(s) Animals ; Bone Morphogenetic Proteins/metabolism ; Bone and Bones/metabolism ; Fibroblast Growth Factors/metabolism ; Humans ; Interleukin-11/metabolism ; Lipocalins/metabolism ; Osteocalcin/metabolism
    Chemical Substances Bone Morphogenetic Proteins ; Interleukin-11 ; Lipocalins ; fibroblast growth factor 23 ; Osteocalcin (104982-03-8) ; Fibroblast Growth Factors (62031-54-3)
    Language Japanese
    Publishing date 2018
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1801915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Skeleton and glucose metabolism: a bone-pancreas loop.

    Faienza, Maria Felicia / Luce, Vincenza / Ventura, Annamaria / Colaianni, Graziana / Colucci, Silvia / Cavallo, Luciano / Grano, Maria / Brunetti, Giacomina

    International journal of endocrinology

    2015  Volume 2015, Page(s) 758148

    Abstract: ... function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ ... function and glucose metabolism. ... as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin ...

    Abstract Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine "gland" and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.
    Language English
    Publishing date 2015-03-19
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2502951-4
    ISSN 1687-8345 ; 1687-8337
    ISSN (online) 1687-8345
    ISSN 1687-8337
    DOI 10.1155/2015/758148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Regulation of male fertility by the bone-derived hormone osteocalcin.

    Karsenty, Gerard / Oury, Franck

    Molecular and cellular endocrinology

    2013  Volume 382, Issue 1, Page(s) 521–526

    Abstract: ... osteocalcin, the skeleton regulates glucose homeostasis and male reproductive functions ... but it is also an endocrine organ itself. Through the secretion of an osteoblast-derived molecule ... that osteocalcin acts via a pancreas-bone-testis axis that regulates, independently of and in parallel ...

    Abstract Traditionally, bone has been viewed as a relatively static tissue only fulfilling mechanical and scaffolding function. In the past decade however, this classical view of the bone has considerably evolved towards a more complex picture. It is now clear that the skeleton is not only a recipient for hormonal input but it is also an endocrine organ itself. Through the secretion of an osteoblast-derived molecule, osteocalcin, the skeleton regulates glucose homeostasis and male reproductive functions. When undercarboxylated, osteocalcin acts following its binding to a G-coupled receptor, Gprc6a, on pancreatic β cells to increase insulin secretion, on muscle and white adipose tissue to promote glucose homeostasis and on Leydig cells of the testis to favor testosterone biosynthesis. More recently, it was also shown that osteocalcin acts via a pancreas-bone-testis axis that regulates, independently of and in parallel to the hypothalamus-pituitary-testis axis, male reproductive functions by promoting testosterone biosynthesis. Lastly, in trying to expand the biological relevance of osteocalcin from mouse to human, it was shown that Gprc6a is a potential new susceptibility locus for primary testicular failure in humans. Altogether, these results shed new light on the importance of the endocrine role of the skeleton and also provide credence to the search for additional endocrine functions of this organ.
    MeSH term(s) Animals ; Bone and Bones/metabolism ; Bone and Bones/physiology ; Fertility/physiology ; Hormones/metabolism ; Humans ; Male ; Osteocalcin/metabolism ; Reproduction/physiology ; Testosterone/biosynthesis
    Chemical Substances Hormones ; Osteocalcin (104982-03-8) ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2013-10-19
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2013.10.008
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1127: Show issues Location:
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  8. Article: Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts.

    Han, Yujiao / You, Xiuling / Xing, Wenhui / Zhang, Zhong / Zou, Weiguo

    Bone research

    2018  Volume 6, Page(s) 16

    Abstract: ... secreted by osteoblasts regulates systemic glucose and energy metabolism, reproduction, and cognition ... is produced by osteoblasts and osteocytes and can regulate phosphate metabolism. Osteocalcin (OCN ... The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone cells ...

    Abstract The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on osteoblastogenesis, osteclastogenesis, and angiogenesis in a paracrine manner. Osteoblasts secrete a range of different molecules including RANKL/OPG, M-CSF, SEMA3A, WNT5A, and WNT16 that regulate osteoclastogenesis. Osteoblasts also produce VEGFA that stimulates osteoblastogenesis and angiogenesis. Osteocytes produce sclerostin (SOST) that inhibits osteoblast differentiation and promotes osteoclast differentiation. Osteoclasts secrete factors including BMP6, CTHRC1, EFNB2, S1P, WNT10B, SEMA4D, and CT-1 that act on osteoblasts and osteocytes, and thereby influenceaA osteogenesis. Osteoclast precursors produce the angiogenic factor PDGF-BB to promote the formation of Type H vessels, which then stimulate osteoblastogenesis. Besides, the evidences over the past decades show that at least three hormones or "osteokines" from bone cells have endocrine functions. FGF23 is produced by osteoblasts and osteocytes and can regulate phosphate metabolism. Osteocalcin (OCN) secreted by osteoblasts regulates systemic glucose and energy metabolism, reproduction, and cognition. Lipocalin-2 (LCN2) is secreted by osteoblasts and can influence energy metabolism by suppressing appetite in the brain. We review the recent progresses in the paracrine and endocrine functions of the secretory proteins of osteoblasts, osteocytes, and osteoclasts, revealing connections of the skeleton with other tissues and providing added insights into the pathogenesis of degenerative diseases affecting multiple organs and the drug discovery process.
    Language English
    Publishing date 2018-05-24
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2803313-9
    ISSN 2095-6231 ; 2095-4700
    ISSN (online) 2095-6231
    ISSN 2095-4700
    DOI 10.1038/s41413-018-0019-6
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  9. Article: [Bone remodeling and glucose/lipid metabolism].

    Yoshizawa, Tatsuya

    Clinical calcium

    2011  Volume 21, Issue 5, Page(s) 709–714

    Abstract: ... This finding established that bone is an important endocrine organ to regulate glucose/lipid metabolism ... lipid metabolism. The bone/glucose metabolism interaction established by these studies will be important to a study ... It has been demonstrated that osteocalcin, osteoblast-derived molecule, regulates glucose ...

    Abstract It has been demonstrated that osteocalcin, osteoblast-derived molecule, regulates glucose/lipid metabolism through increasing insulin secretion from pancreas and insulin sensitivity in peripheral tissues. This finding established that bone is an important endocrine organ to regulate glucose/lipid metabolism. Recently, it has been reported that insulin signaling in osteoblasts was a positive regulator of bone acquisition, but also of bone resorption. Interestingly, insulin signaling in osteoblasts activated osteocalcin embedded in bone ECM by stimulating resorption activity in osteoclast. This finding indicated that the osteoblasts is an important target cells used by insulin which playing a central role in glucose/lipid metabolism. The bone/glucose metabolism interaction established by these studies will be important to a study of the two fields in the future, particularly a clinical field.
    MeSH term(s) Animals ; Bone Remodeling/physiology ; Bone Resorption ; Bone and Bones/metabolism ; Carbohydrate Metabolism/physiology ; Glucose/metabolism ; Humans ; Insulin/metabolism ; Insulin/physiology ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Lipid Metabolism/physiology ; Mice ; Osteoblasts/physiology ; Osteocalcin/physiology ; Osteoclasts ; Receptor, Insulin/physiology ; Signal Transduction/physiology
    Chemical Substances Insulin ; Osteocalcin (104982-03-8) ; Receptor, Insulin (EC 2.7.10.1) ; Glucose (IY9XDZ35W2)
    Language Japanese
    Publishing date 2011-04-16
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1105709714
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6536: Show issues Location:
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  10. Article ; Online: Os et métabolisme.

    Marsot, Charlotte / Chanson, Philippe / Borson-Chazot, Françoise

    Annales d'endocrinologie

    2018  Volume 79 Suppl 1, Page(s) S40–S47

    Abstract: ... glucose metabolism via osteocalcin and energy metabolism, thanks to lipocalin 2, a new hormone acting ... Bone is now considered as a particular endocrine organ. Its endocrine function is not yet fully ... demineralization. Recent findings on the role of bone on glucose and mineral metabolism could open therapeutic ...

    Title translation Bone and metabolism.
    Abstract Bone is now considered as a particular endocrine organ. Its endocrine function is not yet fully understood and has been the subject of several conferences at the European Society of Endocrinology Congress 2018. Bone regulates phosphate metabolism by secreting fibroblast growth factor 23; it also regulates glucose metabolism via osteocalcin and energy metabolism, thanks to lipocalin 2, a new hormone acting on the brain. In addition, the incidence of diabetes continues to grow, and its impact on bone has been demonstrated, with an increased risk of fractures regardless the type of diabetes. The mechanism of bone fragility in this disease is not fully known but it involves a decrease in bone turnover and bone demineralization. Recent findings on the role of bone on glucose and mineral metabolism could open therapeutic perspectives, especially for the treatment of diabetes or obesity.
    MeSH term(s) Bone Demineralization, Pathologic/etiology ; Bone Remodeling ; Bone and Bones/physiology ; Diabetes Complications ; Diabetes Mellitus/epidemiology ; Endocrine Glands/physiology ; Energy Metabolism ; Fibroblast Growth Factors/physiology ; Fractures, Bone/etiology ; Glucose/metabolism ; Humans ; Lipocalin-2/physiology ; Metabolism/physiology ; Minerals/metabolism ; Osteocalcin/physiology ; Phosphates/metabolism ; Risk Factors
    Chemical Substances Lipocalin-2 ; Minerals ; Phosphates ; fibroblast growth factor 23 ; Osteocalcin (104982-03-8) ; Fibroblast Growth Factors (62031-54-3) ; Glucose (IY9XDZ35W2)
    Language French
    Publishing date 2018-09-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/S0003-4266(18)31236-8
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