Article ; Online: Prevalence and impact of comorbidities on disease prognosis among patients with COVID-19 in Bangladesh: A nationwide study amid the second wave.
2021 Volume 15, Issue 4, Page(s) 102148
Abstract: ... fatality in patients with COVID-19 suggested by studies in various countries, but study in Bangladesh is ... with the prognosis of adverse health outcomes in patients with COVID-19 in Bangladesh.: Methods: A multivariate ... higher CCI were associated with increased hospitalization, severity and fatality in patients with COVID ...
| Abstract | Background: Socio-demographics and comorbidities are involved in determining the severity and fatality in patients with COVID-19 suggested by studies in various countries, but study in Bangladesh is insufficient. Aims: We designed the study to evaluate the association of sociodemographic and comorbidities with the prognosis of adverse health outcomes in patients with COVID-19 in Bangladesh. Methods: A multivariate retrospective cohort study was conducted on data from 966 RT-PCR positive patients from eight divisions during December 13, 2020, to February 13, 2021. Variables included sociodemographic, comorbidities, symptoms, Charlson comorbidity index (CCI) and access to health facilities. Major outcome was fatality. Secondary outcomes included hospitalization, duration of hospital stay, requirement of mechanical ventilation and severity. Results: Male (65.8%, 636 of 966) was predominant and mean age was 39.8 ± 12.6 years. Fever (79%), dry cough (55%), and loss of test/smell (51%) were frequent and 74% patients had >3 symptoms. Fatality was recorded in 10.5% patients. Comorbidities were found in 44% patients. Hypertension (21.5%) diabetes (14.6%), and cardiovascular diseases (11.3%) were most prevalent. Age >60 years (OR: 4.83, 95% CI: 2.45-6.49), and CCI >3 (OR: 5.48, 95% CI: 3.95-7.24) were predictors of hospitalizations. CCI >4 (aOR: 3.41, 95% CI: 2.57-6.09) was predictor of severity. Age >60 years (aOR: 3.77, 95% CI: 1.07-6.34), >3 symptoms (aOR: 2.14, 95% CI: 0.97-4.91) and CCI >3 vs. CCI <3 (aOR: 5.23, 95% CI: 3.77-8.09) were independently associated with fatality. Conclusions: Increased age, >3 symptoms, increasing comorbidities, higher CCI were associated with increased hospitalization, severity and fatality in patients with COVID-19. |
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| MeSH term(s) | Adolescent ; Adult ; Age Factors ; Aged ; Bangladesh/epidemiology ; COVID-19/complications ; COVID-19/transmission ; COVID-19/virology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/virology ; Child ; Child, Preschool ; Comorbidity ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/mortality ; Diabetes Mellitus/pathology ; Diabetes Mellitus/virology ; Female ; Hospitalization/statistics & numerical data ; Humans ; Hypertension/epidemiology ; Hypertension/mortality ; Hypertension/pathology ; Hypertension/virology ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; SARS-CoV-2/isolation & purification ; Survival Rate ; Young Adult |
| Language | English |
| Publishing date | 2021-06-27 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 2273766-2 |
| ISSN | 1878-0334 ; 1871-4021 |
| ISSN (online) | 1878-0334 |
| ISSN | 1871-4021 |
| DOI | 10.1016/j.dsx.2021.05.021 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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