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Article: Cardiovascular manifestations of COVID-19: An evidence-based narrative review.

Sharma, Yash Paul / Agstam, Sourabh / Yadav, Ashutosh / Gupta, Anunay / Gupta, Ankur

The Indian journal of medical research

2021  Volume 153, Issue 1 & 2, Page(s) 7–16

Abstract: ... between COVID-19 and cardiovascular manifestations requires an in-depth understanding for appropriate ... cardiovascular manifestations of COVID-19. ... mortality in COVID-19. Patients with underlying cardiovascular diseases and conventional cardiovascular ...

Abstract The recent outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization on March 11, 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, primarily involves the respiratory system with viral pneumonia as a predominant manifestation. In addition, SARS-CoV-2 has various cardiovascular manifestations which increase morbidity and mortality in COVID-19. Patients with underlying cardiovascular diseases and conventional cardiovascular risk factors are predisposed for COVID-19 with worse prognosis. The possible mechanisms of cardiovascular injury are endothelial dysfunction, diffuse microangiopathy with thrombosis and increased angiotensin II levels. Hyperinflammation in the myocardium can result in acute coronary syndrome, myocarditis, heart failure, cardiac arrhythmias and sudden death. The high level of cardiac troponins and natriuretic peptides in the early course of COVID-19 reflects an acute myocardial injury. The complex association between COVID-19 and cardiovascular manifestations requires an in-depth understanding for appropriate management of these patients. Till the time a specific antiviral drug is available for COVID-19, treatment remains symptomatic. This review provides information on the cardiovascular risk factors and cardiovascular manifestations of COVID-19.
MeSH term(s) COVID-19/complications ; Cardiovascular Diseases/virology ; Heart Disease Risk Factors ; Humans ; Pandemics
Language English
Publishing date 2021-02-26
Publishing country India
Document type Journal Article ; Review
ZDB-ID 390883-5
ISSN 0971-5916 ; 0019-5340
ISSN 0971-5916 ; 0019-5340
DOI 10.4103/ijmr.IJMR_2450_20
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