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  1. Article ; Online: Elevated Procalcitonin Is Positively Associated with the Severity of COVID-19: A Meta-Analysis Based on 10 Cohort Studies.

    Shen, Yue / Cheng, Cheng / Zheng, Xue / Jin, Yuefei / Duan, Guangcai / Chen, Mengshi / Chen, Shuaiyin

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 6

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) COVID-19 ; Cohort Studies ; Humans ; Procalcitonin ; Prognosis ; SARS-CoV-2
    Chemical Substances Procalcitonin
    Language English
    Publishing date 2021-06-09
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57060594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Elevated Procalcitonin Is Positively Associated with the Severity of COVID-19

    Yue Shen / Cheng Cheng / Xue Zheng / Yuefei Jin / Guangcai Duan / Mengshi Chen / Shuaiyin Chen

    Medicina, Vol 57, Iss 594, p

    A Meta-Analysis Based on 10 Cohort Studies

    2021  Volume 594

    Abstract: ... 0.106). Conclusions: Higher procalcitonin is positively associated with the severity of COVID-19 ... Background and Objectives : Procalcitonin (PCT) is positively associated with the severity of COVID ... the severity of COVID-19 decreased. Subgroup analysis revealed heterogeneity between studies and ...

    Abstract Background and Objectives : Procalcitonin (PCT) is positively associated with the severity of COVID-19 (including severe, critical, or fatal outcomes), but some of the confounding factors are not considered. The aim of this meta-analysis was to estimate the adjusted relationship between elevated procalcitonin on admission and the severity of COVID-19. Materials and Methods: We searched 1805 articles from PubMed, Web of Science, and Embase databases up to 2 April 2021. The articles were selected which reported the adjusted relationship applying multivariate analysis between PCT and the severity of COVID-19. The pooled effect estimate was calculated by the random-effects model. Results: The meta-analysis included 10 cohort studies with a total of 7716 patients. Patients with elevated procalcitonin on admission were at a higher risk of severe and critical COVID-19 (pooled effect estimate: 1.77, 95% confidence interval (CI): 1.38–2.29; I 2 = 85.6%, p < 0.001). Similar results were also observed in dead patients (pooled effect estimate: 1.77, 95% CI: 1.36–2.30). After adjusting for diabetes, the positive association between PCT and the severity of COVID-19 decreased. Subgroup analysis revealed heterogeneity between studies and sensitivity analysis showed that the results were robust. There was no evidence of publication bias by Egger’s test ( p = 0.106). Conclusions: Higher procalcitonin is positively associated with the severity of COVID-19, which is a potential biomarker to evaluate the severity of COVID-19 and predict the prognosis.
    Keywords COVID-19 ; SARS-CoV-2 ; procalcitonin ; severity ; meta-analysis ; Medicine (General) ; R5-920
    Subject code 150
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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