Artikel ; Online: Modeling the integration of bacterial rRNA fragments into the human cancer genome.
2016 Band 17, Seite(n) 134
Abstract: ... the integration of exogenous DNA into the human somatic genome. We previously identified in silico evidence of DNA ... in stomach cancer sequencing data. The functional and biological consequences of these bacterial DNA integrations ... fragments from a Pseudomonas-like bacteria integrating into the 5'-UTR of four proto-oncogenes ...
| Abstract | Background: Cancer is a disease driven by the accumulation of genomic alterations, including the integration of exogenous DNA into the human somatic genome. We previously identified in silico evidence of DNA fragments from a Pseudomonas-like bacteria integrating into the 5'-UTR of four proto-oncogenes in stomach cancer sequencing data. The functional and biological consequences of these bacterial DNA integrations remain unknown. Results: Modeling of these integrations suggests that the previously identified sequences cover most of the sequence flanking the junction between the bacterial and human DNA. Further examination of these reads reveals that these integrations are rich in guanine nucleotides and the integrated bacterial DNA may have complex transcript secondary structures. Conclusions: The models presented here lay the foundation for future experiments to test if bacterial DNA integrations alter the transcription of the human genes. |
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| Mesh-Begriff(e) | 5' Untranslated Regions ; Antigens, CD/genetics ; Antigens, Differentiation, B-Lymphocyte/genetics ; Carcinoembryonic Antigen/genetics ; Cell Adhesion Molecules/genetics ; GPI-Linked Proteins/genetics ; Genome, Human ; Histocompatibility Antigens Class II/genetics ; Host-Parasite Interactions/genetics ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Nucleic Acid Conformation ; Pseudomonas/genetics ; RNA, Ribosomal/chemistry ; RNA, Ribosomal/genetics ; RNA, Ribosomal/metabolism ; Recombination, Genetic |
| Chemische Substanzen | 5' Untranslated Regions ; Antigens, CD ; Antigens, Differentiation, B-Lymphocyte ; CEACAM5 protein, human ; CEACAM6 protein, human ; Carcinoembryonic Antigen ; Cell Adhesion Molecules ; GPI-Linked Proteins ; Histocompatibility Antigens Class II ; RNA, Ribosomal ; invariant chain |
| Sprache | Englisch |
| Erscheinungsdatum | 2016-03-21 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2041484-5 |
| ISSN | 1471-2105 ; 1471-2105 |
| ISSN (online) | 1471-2105 |
| ISSN | 1471-2105 |
| DOI | 10.1186/s12859-016-0982-0 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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