Article: Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
2003 Volume 284, Issue 3, Page(s) L435–51
Abstract: ... their effect on lung endothelial permeability. Specifically, alpha-thrombin, tumor necrosis factor (TNF)-alpha ... in the pulmonary endothelial response to agents involved in lung injury characteristic of the respiratory distress ... syndrome. Thus the paradigms of PKC-induced lung injury are discussed within the context of pulmonary ...
| Abstract | The intracellular serine/threonine kinase protein kinase C (PKC) has an important role in the genesis of pulmonary edema. This review discusses the PKC-mediated mechanisms that participate in the pulmonary endothelial response to agents involved in lung injury characteristic of the respiratory distress syndrome. Thus the paradigms of PKC-induced lung injury are discussed within the context of pulmonary transvascular fluid exchange. We focus on the signal transduction pathways that are modulated by PKC and their effect on lung endothelial permeability. Specifically, alpha-thrombin, tumor necrosis factor (TNF)-alpha, and reactive oxygen species are discussed because of their well-established roles in both human and experimental lung injury. We conclude that PKC, most likely PKC-alpha, is a primary supporter for lung endothelial injury in response to alpha-thrombin, TNF-alpha, and reactive oxygen species. |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MeSH term(s) | Animals ; Capillary Permeability ; Endothelium, Vascular/enzymology ; Feedback, Physiological ; Humans ; Lung/enzymology ; Lung/physiopathology ; Phorbol Esters ; Protein Kinase C/metabolism ; Pulmonary Edema/etiology ; Pulmonary Edema/physiopathology ; Reactive Oxygen Species/metabolism ; Respiratory Distress Syndrome, Adult/chemically induced ; Respiratory Distress Syndrome, Adult/complications ; Respiratory Distress Syndrome, Adult/physiopathology ; Signal Transduction ; Thrombin ; Tumor Necrosis Factor-alpha | ||||||||||
| Chemical Substances | Phorbol Esters ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Protein Kinase C (EC 2.7.11.13) ; Thrombin (EC 3.4.21.5) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2003-02-06 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Review | ||||||||||
| ZDB-ID | 1013184-x | ||||||||||
| ISSN | 1522-1504 ; 1040-0605 | ||||||||||
| ISSN (online) | 1522-1504 | ||||||||||
| ISSN | 1040-0605 | ||||||||||
| DOI | 10.1152/ajplung.00106.2002 | ||||||||||
| Shelf mark |
|
||||||||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uc I Zs.89: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.A 2749: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.