Article ; Online: Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A₂ (Lp-PLA₂): a review.
Lipids in health and disease
2011 Volume 10, Page(s) 170
Abstract: ... The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery ... and concentration. Thus, the effects of these treatments on Lp-PLA2 may represent a new kind ... The association of cardiovascular events with Lp-PLA2 has been studied continuously today ...
| Abstract | The association of cardiovascular events with Lp-PLA2 has been studied continuously today. The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery was directly related to the hydrolysis of the platelet-activating factor and oxidized phospholipids, which are considered protective functions. However, the hydrolysis of bioactive lipids generates lysophospholipids, compounds that have a pro-inflammatory function. Therefore, the evaluation of the distribution of Lp-PLA2 in the lipid fractions emphasized the dual role of the enzyme in the inflammatory process, since the HDL-Lp-PLA2 enzyme contributes to the reduction of atherosclerosis, while LDL-Lp-PLA2 stimulates this process. Recently, it has been verified that diet components and drugs can influence the enzyme activity and concentration. Thus, the effects of these treatments on Lp-PLA2 may represent a new kind of prevention of cardiovascular disease. Therefore, the association of the enzyme with the traditional assessment of cardiovascular risk may help to predict more accurately these diseases. |
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| MeSH term(s) | 1-Alkyl-2-acetylglycerophosphocholine Esterase/antagonists & inhibitors ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/chemistry ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism ; Animals ; Anticholesteremic Agents/therapeutic use ; Antioxidants/metabolism ; Atherosclerosis/blood ; Atherosclerosis/epidemiology ; Atherosclerosis/metabolism ; Atherosclerosis/prevention & control ; Humans ; Inflammation Mediators/blood ; Inflammation Mediators/metabolism ; Lipoproteins, LDL/blood ; Lipoproteins, LDL/metabolism ; Lysophospholipids/blood ; Lysophospholipids/metabolism ; Molecular Targeted Therapy ; Oxidative Stress ; Risk Factors |
| Chemical Substances | Anticholesteremic Agents ; Antioxidants ; Inflammation Mediators ; Lipoproteins, LDL ; Lysophospholipids ; oxidized low density lipoprotein ; 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47) |
| Language | English |
| Publishing date | 2011-09-28 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ISSN | 1476-511X |
| ISSN (online) | 1476-511X |
| DOI | 10.1186/1476-511X-10-170 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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