Article ; Online: Persistent Exertional Intolerance After COVID-19: Insights From Invasive Cardiopulmonary Exercise Testing.
2021 Volume 161, Issue 1, Page(s) 54–63
Abstract: ... invasive cardiopulmonary exercise testing (iCPET) and compared the results with those from 10 age- and sex ... recovered from COVID-19 exhibited markedly reduced peak exercise aerobic capacity (oxygen consumption [VO ... intolerance that underlies the post-COVID-19 long-haul syndrome in patients without cardiopulmonary ...
| Abstract | Background: Some patients with COVID-19 who have recovered from the acute infection after experiencing only mild symptoms continue to exhibit persistent exertional limitation that often is unexplained by conventional investigative studies. Research question: What is the pathophysiologic mechanism of exercise intolerance that underlies the post-COVID-19 long-haul syndrome in patients without cardiopulmonary disease? Study design and methods: This study examined the systemic and pulmonary hemodynamics, ventilation, and gas exchange in 10 patients who recovered from COVID-19 and were without cardiopulmonary disease during invasive cardiopulmonary exercise testing (iCPET) and compared the results with those from 10 age- and sex-matched control participants. These data then were used to define potential reasons for exertional limitation in the cohort of patients who had recovered from COVID-19. Results: The patients who had recovered from COVID-19 exhibited markedly reduced peak exercise aerobic capacity (oxygen consumption [VO Interpretation: Patients who have recovered from COVID-19 without cardiopulmonary disease demonstrate a marked reduction in peak VO |
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| MeSH term(s) | COVID-19/complications ; COVID-19/physiopathology ; Connecticut ; Exercise Test/methods ; Exercise Tolerance ; Female ; Hemodynamics/physiology ; Humans ; Male ; Massachusetts ; Middle Aged ; Oxygen Consumption/physiology ; Respiratory Function Tests ; SARS-CoV-2 ; Stroke Volume/physiology | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-08-11 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 1032552-9 | ||||||||||
| ISSN | 1931-3543 ; 0012-3692 | ||||||||||
| ISSN (online) | 1931-3543 | ||||||||||
| ISSN | 0012-3692 | ||||||||||
| DOI | 10.1016/j.chest.2021.08.010 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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