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  1. Article: Surgical palliation for pancreatic cancer. The UCLA experience.

    Singh, S M / Longmire, W P / Reber, H A

    Annals of surgery

    1990  Volume 212, Issue 2, Page(s) 132–139

    Abstract: ... Surgical palliation for pancreatic cancer was generally effective and was associated with an operative ... I), 173 had some form of surgical palliation (group II), and 106 had neither (group III). The diagnosis ... at UCLA Medical Center between 1973 and 1988. Sixty-one patients underwent pancreatic resection (group ...

    Abstract We reviewed the records of 340 patients with a tissue diagnosis of pancreatic cancer treated at UCLA Medical Center between 1973 and 1988. Sixty-one patients underwent pancreatic resection (group I), 173 had some form of surgical palliation (group II), and 106 had neither (group III). The diagnosis was made 1 to 2 months more quickly in the last 8 years of the review than in the first 8 years, but the effect of early diagnosis on curability was negligible. Biliary obstruction was best treated by cholecystojejunostomy or choledochojejunostomy, which were equally effective. Anastomoses to the jejunum were safer and more effective than were those to the duodenum for the relief of biliary obstruction. Gastrojejunostomy should be performed prophylactically as well as therapeutically. It was effective and safe in both settings. Surgical palliation for pancreatic cancer was generally effective and was associated with an operative mortality rate of less than 10%. However morbidity was high, with significant complications occurring in one third of cases.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Intraductal, Noninfiltrating/complications ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Child ; Choledochostomy ; Cholestasis/etiology ; Cholestasis/surgery ; Female ; Humans ; Male ; Middle Aged ; Palliative Care ; Pancreatectomy ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/surgery ; Retrospective Studies
    Language English
    Publishing date 1990-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/00000658-199008000-00003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Surgical treatment of pancreatic cancer. The United States experience.

    Livingston, E H / Welton, M L / Reber, H A

    International journal of pancreatology : official journal of the International Association of Pancreatology

    1991  Volume 9, Page(s) 153–157

    Abstract: ... palliation is less than 10% (recent UCLA experience), and the average survival is seven months. ... About 28,000 new cases of pancreatic cancer are diagnosed yearly in the United States ... a resection for attempted cure is about 9%. Palliation requires cholecysto(docho)jejunostomy and ...

    Abstract About 28,000 new cases of pancreatic cancer are diagnosed yearly in the United States. The diagnosis is now made up to two months more quickly than just a few years ago, but this has had no impact on survival. In most institutions, 20-25% of patients have resectable lesions. The standard operation is still the Whipple pancreaticoduodenectomy, but many surgeons now use the pylorus preserving modification of that procedure. The operative mortality rate has fallen to less than 5%. The five-year survival rate after a resection for attempted cure is about 9%. Palliation requires cholecysto(docho)jejunostomy and gastrojejunostomy, which is often done prophylactically. The operative mortality rate in patients undergoing palliation is less than 10% (recent UCLA experience), and the average survival is seven months.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/mortality ; Adenocarcinoma/surgery ; Chemotherapy, Adjuvant ; Duodenal Obstruction/complications ; Duodenal Obstruction/prevention & control ; Duodenal Obstruction/surgery ; Humans ; Jaundice/complications ; Jaundice/surgery ; Palliative Care ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/surgery ; Survival Analysis ; United States
    Language English
    Publishing date 1991
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632897-0
    ISSN 0169-4197
    ISSN 0169-4197
    DOI 10.1007/bf02925591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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