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Article: Managing pregnancy in COVID-19 pandemic: A review article.

Singh, Vinita / Trigunait, Pragati / Majumdar, Sagarika / Ganeshan, Rajeshwari / Sahu, Rajshree

Journal of family medicine and primary care

2020 Volume 9, Issue 11, Page(s) 5468–5473

Abstract: ... pregnant women and newborn with suspected or confirmed COVID-19. All the published papers till date, NCPRE ... globe and hence declare pandemic. Pregnancy alters body physiology and immune systems, can have worse ... The outbreak Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused ...

Abstract	The outbreak Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a highly contagious and lethal beta coronavirus SARS-CoV-2, which has spread fast to encroach the entire globe and hence declare pandemic. Pregnancy alters body physiology and immune systems, can have worse effects of some respiratory infections and due to limited research and published data we still are in dilemma of appropriate management guidelines This article covers the updated guidelines for infection prevention and control (IPC), screening, sampling, antenatal visit schedules, risk scoring, triaging, supportive care, delivery, postpartum care and care of the newborn. This article aims to provide up-to-date information as per recent guidelines of various association which would serve as guidance in managing pregnant women and newborn with suspected or confirmed COVID-19. All the published papers till date, NCPRE, WHO Interim guidelines, RCOG, FOGS GCPRI, Medical Council of India
Language	English
Publishing date	2020-11-30
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_950_20
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Article ; Online: Managing pregnancy in COVID-19 pandemic

Vinita Singh / Pragati Trigunait / Sagarika Majumdar / Rajeshwari Ganeshan / Rajshree Sahu

Journal of Family Medicine and Primary Care, Vol 9, Iss 11, Pp 5468-

A review article

2020 Volume 5473

Abstract: ... during COVID-19 pandemic. This article covers the not only infection prevention and control (IPC ... pregnant women and newborn with suspected or confirmed COVID-19. All the published papers till date, NCPRE ... globe and hence declare pandemic. Pregnancy alters body physiology and immune systems, can have worse ...

Abstract	The outbreak Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a highly contagious and lethal beta coronavirus SARS-CoV-2, which has spread fast to encroach the entire globe and hence declare pandemic. Pregnancy alters body physiology and immune systems, can have worse effects of some respiratory infections and due to limited research and published data we still are in dilemma of appropriate management guidelines This article covers the updated guidelines for infection prevention and control (IPC), screening, sampling, antenatal visit schedules, risk scoring, triaging, supportive care, delivery, postpartum care and care of the newborn. This article aims to provide up-to-date information as per recent guidelines of various association which would serve as guidance in managing pregnant women and newborn with suspected or confirmed COVID-19. All the published papers till date, NCPRE, WHO Interim guidelines, RCOG, FOGS GCPRI, Medical Council of India, ICMR, MOFHW, CDC, ACOG guidelines are referred to compile this article to reach to a conclusion of evidence based management of pregnant ladies during COVID-19 pandemic. This article covers the not only infection prevention and control (IPC) guidelines, but also screening and sampling guidelines, antenatal visit schedules, risk scoring, triaging but also in-patient supportive care, delivery, postpartum care and care of the newborn. Data are very limited and hence very difficult to accurately define clinical management strategies and needs to be constantly updated.
Keywords	breast feeding ; covid-19 ; newborn care ; pandemic ; pregnancy ; sari ; sars-cov-2 ; Medicine ; R
Subject code	360
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Telemedical Approaches to Managing Gestational Diabetes Mellitus During COVID-19: Systematic Review.

Eberle, Claudia / Stichling, Stefanie

JMIR pediatrics and parenting

2021 Volume 4, Issue 3, Page(s) e28630

Abstract: ... COVID-19) was rapidly classified as a pandemic. Pregnant women with gestational diabetes mellitus (GDM ... are considered to be at risk for severe COVID-19. In the context of the pandemic, there are serious ... control during the COVID-19 pandemic.: Methods: Publications were systematically identified ...

Abstract	Background: In 2019, a new coronavirus emerged in China, and the disease caused by the virus (COVID-19) was rapidly classified as a pandemic. Pregnant women with gestational diabetes mellitus (GDM) are considered to be at risk for severe COVID-19. In the context of the pandemic, there are serious concerns regarding adverse effects on maternal and neonatal outcomes for women with GDM. Effective treatments for patients with GDM are therefore particularly important. Due to contact restrictions and infection risks, digital approaches such as telemedicine are suitable alternatives. Objective: This systematic review aims to summarize currently available evidence on maternal and offspring outcomes of pregnant women with GDM and COVID-19 and to examine telemedical interventions to improve maternal glycemic control during the COVID-19 pandemic. Methods: Publications were systematically identified by searching the Cochrane Library, MEDLINE via PubMed, Web of Science Core Collection, Embase, and CINAHL databases for studies published up to March 2021. We sorted the COVID-19 studies by outcome and divided the telemedical intervention studies into web-based and app-based groups. We analyzed case reports (COVID-19) and both randomized and nonrandomized controlled clinical trials (telemedicine). To determine the change in glycated hemoglobin A Results: Regarding COVID-19 studies, we identified 11 case reports, 3 letters, 1 case series, and 1 retrospective single-center study. In total, 41 patients with GDM and COVID-19 were analyzed. The maternal and neonatal outcomes were extremely heterogeneous. We identified adverse outcomes for mother and child through the interaction of GDM and COVID-19, such as cesarean deliveries and low Apgar scores. Furthermore, we selected 9 telemedicine-related articles: 6 were randomized controlled trials, 2 were clinical controlled trials, and 1 was a quasi-experimental design. In total, we analyzed 480 patients with GDM in the intervention groups and 494 in the control groups. Regarding the quality of the 9 telemedical studies, 4 were rated as strong, 4 as moderate, and 1 as weak. Telemedical interventions can contribute to favorable impacts on HbA Conclusions: Telemedicine is an effective approach in the context of COVID-19 and GDM because it enables social distancing and represents optimal care of patients with GDM, especially with regard to glycemic control, which is very important in view of the identified adverse maternal and neonatal outcomes. Further research is needed.
Language	English
Publishing date	2021-08-05
Publishing country	Canada
Document type	Journal Article ; Review
ISSN	2561-6722
ISSN (online)	2561-6722
DOI	10.2196/28630
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Article ; Online: Update to Perinatal-Neonatal Management of COVID-19 Guidelines.

Sivanandan, Sindhu / Chawla, Deepak / Kumar, Praveen

Indian pediatrics

2021 Volume 59, Issue 1, Page(s) 63–66

Abstract: ... the salient changes inthe perinatal-neonatal management of COVID-19. ... impact on mother-infant dyads led us to review and revise the guideline. This article summarizes ... The guidelines for diagnosing and managing perinatal SARS-CoV-2 infection for the Indian context ...

Abstract	The guidelines for diagnosing and managing perinatal SARS-CoV-2 infection for the Indian context were last updated in May 2020. Newer evidence, the evolution of the pandemic, and its significant impact on mother-infant dyads led us to review and revise the guideline. This article summarizes the salient changes inthe perinatal-neonatal management of COVID-19.
MeSH term(s)	COVID-19 ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Pandemics ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Infectious/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2021-11-22
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article: Critical Care Management of Severe COVID-19 in Pregnant Patients.

Ghafoor, Hashsaam / Abdus Samad, Aijaz / Bel Khair, Ali O Mohamed / Ahmed, Osman / Khan, Muhammad Nasir Ayub

Cureus

2022 Volume 14, Issue 5, Page(s) e24885

Abstract: ... confirmed COVID-19. In this review article, we discuss the epidemiology of COVID-19 during delivery ... its effect on the physiological and immunological changes during pregnancy, the classification of COVID-19 ... pregnant patients with COVID-19 are commonly hospitalized and often require admission to ICUs and ...

Abstract	Since December 2019, the coronavirus disease (COVID-19) pandemic has had a disastrous impact worldwide. COVID-19 is caused by the SARS-CoV-2 virus and was declared a pandemic by the WHO on March 11, 2020. The virus has been linked to a wide range of respiratory illnesses, ranging from mild symptoms to acute pneumonia and severe respiratory distress syndrome. Pregnant women are more vulnerable to COVID-19 complications owing to the physiological and immunological changes caused by pregnancy. According to the CDC, pregnant patients with COVID-19 are commonly hospitalized and often require admission to ICUs and ventilator support. Therefore, it is especially important for pregnant women to adhere to disease prevention measures to lower the risk of contracting the disease. In addition, the guidelines of several clinical societies and local health authorities should be followed when caring for pregnant women with suspected or confirmed COVID-19. In this review article, we discuss the epidemiology of COVID-19 during delivery, its effect on the physiological and immunological changes during pregnancy, the classification of COVID-19 severity, maternal and fetal risks, antenatal care, respiratory management, treatment/medication safety, timing and mode of delivery, anesthetic considerations, and the outcome of critically ill pregnant patients with COVID-19, as well as their post-delivery care and weaning from mechanical ventilation.
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.24885
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Article: COVID-19 and pregnant women - An overview on diagnosis, treatment approach with limitation, and clinical management.

Pattanashetti, Laxmi / Patil, Santosh / Nyamgouda, Sanath / Bhagiratha, Mahendrakumar / Gadad, Pramod

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2021 Volume 91, Issue 3

Abstract: ... 2. The COVID-19 has been identified to be originated from Wuhan, Hubei, China. This pandemic started ... management of COVID-19 infection in pregnant women. This overview may be useful for health care providers ... specific anti-viral drug for COVID-19 management is recommended in the current scenario ...

Abstract	Coronavirus disease or more popularly called COVID-19 is known to be caused by a novel coronavirus 2. The COVID-19 has been identified to be originated from Wuhan, Hubei, China. This pandemic started in December 2019, and since then it has spread across the world within a short period. The health and family welfare ministry of the Government of India reported 227,546 active, 9,997,272 discharged cases, and 150,114 deaths due to COVID-19 as of 06 January 2021. Indian Council of Medical Research (ICMR) reports that the cumulative testing status of SARS-CoV-2 (COVID-19) was 931,408 up to November 03, 2020. Currently, no specific anti-viral drug for COVID-19 management is recommended in the current scenario. Vulnerable populations such as pregnant women affected by COVID-19 infection need to be recognized and followed up for effective handling concerning morbidity and mortality. At present, very few case reports on COVID-19 infected pregnant women have been published in India and there is no proven exclusive treatment protocol. This article summarizes a review of signs and symptoms, etiopathogenesis, risk factors, diagnosis, and possible management of COVID-19 infection in pregnant women. This overview may be useful for health care providers for practical approach and limitation of drugs used in the current management and considers the choice of drugs with their special attention given to adverse effects to improvise maternal health, pregnancy, and birth outcomes.
MeSH term(s)	COVID-19 ; Female ; Humans ; Pandemics ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Infectious/epidemiology ; Pregnant Women ; SARS-CoV-2
Language	English
Publishing date	2021-06-10
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2021.1785
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Article: WHO's support for COVID-19 research and knowledge management in the Eastern Mediterranean Region.

Rashidian, Arash / Wu, Kaiyue / Al Ariqi, Lubna / Aly, Eman / Mandil, Ahmed / Barakat, Amal / Kodama, Chiori / Kheirandish, Mehrnaz / Nour Eldin Hassan, Hatem / Doctor, Henry Victor / Hemachandra, Nilmini / Fahmy, Kamal / Dingwall, Phillip / Nour, Mohamed / Krishnamurthy Reddiar, Sumithra

BMJ global health

2022 Volume 7, Issue Suppl 3

Abstract: ... to the COVID-19 pandemic. WHO's Eastern Mediterranean Regional Office (EMRO) supports priority research ... initiatives that address gaps in current knowledge regarding the COVID-19 pandemic. Through a specific call ... 2020, scholarly articles on COVID-19 have been published in every issue of the ...

Abstract	Health research, innovation and knowledge management remain major priorities of the WHO's response to the COVID-19 pandemic. WHO's Eastern Mediterranean Regional Office (EMRO) supports priority research initiatives that address gaps in current knowledge regarding the COVID-19 pandemic. Through a specific call for proposals, 122 research proposals were received and reviewed in 2020, of which 17 were recommended for funding from eight countries. Ten countries in the region participated in the global solidarity trial to assess potential therapies for COVID-19. In addition, WHO advocated for early serological and epidemiological investigations ('COVID-19 Unity Studies') on the general population, healthcare workers, pregnant women and neonates, and extending technical, financial and material support for them.Starting in early 2020, scholarly articles on COVID-19 have been published in every issue of the
MeSH term(s)	COVID-19 ; Female ; Humans ; Infant, Newborn ; Knowledge Management ; Pandemics/prevention & control ; Policy Making ; Pregnancy ; World Health Organization
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2059-7908
ISSN	2059-7908
DOI	10.1136/bmjgh-2022-008737
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Article ; Online: Management of Acute Severe Ulcerative Colitis in a Pregnant Woman With COVID-19 Infection: A Case Report and Review of the Literature.

Rosen, Melissa H / Axelrad, Jordan / Hudesman, David / Rubin, David T / Chang, Shannon

Inflammatory bowel diseases

2020 Volume 26, Issue 7, Page(s) 971–973

Abstract: ... trimester of pregnancy who also has COVID-19. The case presentation is followed by a review of the literature to date ... regarding IBD patients with COVID-19 and no data regarding early pregnancy in the era of COVID-19 ... on COVID-19 in regard to inflammatory bowel disease and pregnancy, respectively. ...

Abstract	First detected in Wuhan, China, the novel 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped RNA beta-coronavirus responsible for an unprecedented, worldwide pandemic caused by COVID-19. Optimal management of immunosuppression in inflammatory bowel disease (IBD) patients with COVID-19 infection currently is based on expert opinion, given the novelty of the infection and the corresponding lack of high-level evidence in patients with immune-mediated conditions. There are limited data regarding IBD patients with COVID-19 and no data regarding early pregnancy in the era of COVID-19. This article describes a patient with acute severe ulcerative colitis (UC) during her first trimester of pregnancy who also has COVID-19. The case presentation is followed by a review of the literature to date on COVID-19 in regard to inflammatory bowel disease and pregnancy, respectively.
MeSH term(s)	Abortion, Spontaneous ; Adult ; Antiviral Agents/administration & dosage ; Betacoronavirus/isolation & purification ; C-Reactive Protein/analysis ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Colitis, Ulcerative/blood ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/physiopathology ; Colitis, Ulcerative/therapy ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Cyclosporine/administration & dosage ; Female ; Humans ; Immunosuppressive Agents/administration & dosage ; Methylprednisolone/administration & dosage ; Pandemics ; Patient Acuity ; Pneumonia, Viral/complications ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Pregnancy ; Pregnancy Complications/physiopathology ; Pregnancy Complications/therapy ; Remission Induction/methods ; SARS-CoV-2 ; Sigmoidoscopy/methods ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; C-Reactive Protein (9007-41-4) ; Methylprednisolone (X4W7ZR7023)
Keywords	covid19
Language	English
Publishing date	2020-03-16
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izaa109
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Article ; Online: Effect of and Interventions in Prevention and Management of Maternal Anemia in the Advent of COVID-19

Muthuka, John K. / Fondo, Diana / Wambura, Francis / Mativo, Japheth / Kelly, Oluoch J. / Nabaweesi, Rosemary

medRxiv

Abstract: ... if pregnancy status is associated with COVID-19 severity characterized by a cytokine storm. Methods We searched ... Background There were many unknowns for pregnant women during the COVID-19 pandemic. Most ... 34, P<.00001; I-squared =98%) Conclusion In the advent of COVID-19, maternal anemia interventions ...

Abstract	Background There were many unknowns for pregnant women during the COVID-19 pandemic. Most of these could have been silent however lethal and anemic conditions could escalate the worsening of pregnancy outcomes. Existing evidence indicate that, array of factors is associated with the ability of compromising maternal anemia, some directly and others indirectly. Objective This review aimed at ascertaining the pooled effect of several anemia interventions. Specifically, the aim of this study was to establish if pregnancy status is associated with COVID-19 severity characterized by a cytokine storm. Methods We searched the Google Scholar, PubMed, Scopus, Web of Science, and Embase databases to studies suitable for inclusion in this meta-analysis. Studies examining women of reproductive age on any maternal anemia intervention were included. The risk of bias was assessed using the Cochrane risk of bias tool. Review Manager 5.4.1 was used to calculate rate ratios (RRs) with 95% CIs, which were depicted using forest plots. Quantitative variables were summarized in total numbers and percentages. The effect on prevention, control, management and or treatment of anemia was calculated and compared between the intervention and the comparator arms. Heterogeneity was evaluated with the Cochran Q statistic and Higgins test. Results A total of 11 articles including data for 6,129 were included. With sensitivity analysis, the interventions had a utility of 39% on maternal anemia prevention and management (random effects model RR 0.61, 95% CI 0.43, 0.87; P = 0.006) (X-squared 6=286.98, P<.00001; I-squared=97%). All the interventions against maternal anemia showed an effect of 17% (fixed-effect model RR 0.83, 95% CI 0.79-0.88; P<.00001) (X-squared 7;24=2.93, P=0.57;I-squared = 0%). Education to pregnant women showed a 28% effect (RR 0.72 95% CI 0.58, 0.89), medicinal administration 19% (RR 0.81 95% CI 0.73, 0.90), iron supplementation 17% (RR 0.83 95% CI 0.75, 0.92) and I.V Ferric Carboxy-maltose 15% (RR 0.85 95% CI 0.74, 0.97) (I-squared = 0%). Interventions in African region had a higher (16%) and significant effect compared to other regions (fixed-effects model RR 0.84, 95% CI 0.79-0.89; P<.001) (X-squared 7;25=176.53, P<.00001;I-squared = 7%). Multiple center studies had a significant predictive effect (16%) compared to single center studies (fixed-effects model RR 0.84, 95% CI 0.79-0.89; P<.00001)(967;25=176.53, P<.00001; I-squared=97%) .The year 2020 recorded the highest effect of maternal anemia interventions at 28% (random-effects model RR 0.72, 95% CI 0.67-0.78; P<.00001) (967;23=167.34, P<.00001; I-squared =98%) Conclusion In the advent of COVID-19, maternal anemia interventions were compromised demonstrated by a low effectiveness trend from the year 2020 to the year 2022. During this period, even the most effective and recommended interventions against maternal anemia were somehow affected.
Keywords	covid19
Language	English
Publishing date	2024-02-20
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2024.02.18.24302492
Database	COVID19

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Article ; Online: Effect of and Interventions in Prevention and Management of Maternal Anemia in the Advent of COVID-19

MUTHUKA, JOHN KYALO / Nyamai, Everlyn / Fondo, Dianna / Oluoch, Kelly / Mativo, Japeth / Nabaweesi, Rosemary

medRxiv

Abstract	Background There were many unknowns for pregnant women during the COVID-19 pandemic. Most of these could have been silent however lethal and anemic conditions could escalate the worsening of pregnancy outcomes. Existing evidence indicate that, array of factors is associated with the ability of compromising maternal anemia, some directly and others indirectly. Objective This review aimed at ascertaining the pooled effect of several anemia interventions. Specifically, the aim of this study was to establish if pregnancy status is associated with COVID-19 severity characterized by a cytokine storm. Methods We searched the Google Scholar, PubMed, Scopus, Web of Science, and Embase databases to studies suitable for inclusion in this meta-analysis. Studies examining women of reproductive age on any maternal anemia intervention were included. The risk of bias was assessed using the Cochrane risk of bias tool. Review Manager 5.4.1 was used to calculate rate ratios (RRs) with 95% CIs, which were depicted using forest plots. Quantitative variables were summarized in total numbers and percentages. The effect on prevention, control, management and or treatment of anemia was calculated and compared between the intervention and the comparator arms. Heterogeneity was evaluated with the Cochran Q statistic and Higgins test. Results A total of 11 articles including data for 6,129 were included. With sensitivity analysis, the interventions had a utility of 39% on maternal anemia prevention and management (random effects model RR 0.61, 95% CI 0.43, 0.87; P = 0.006) (X-squared 6=286.98, P<.00001; I-squared=97%). All the interventions against maternal anemia showed an effect of 17% (fixed-effect model RR 0.83, 95% CI 0.79-0.88; P<.00001) (X-squared 7;24=2.93, P=0.57;I-squared = 0%). Education to pregnant women showed a 28% effect (RR 0.72 95% CI 0.58, 0.89), medicinal administration 19% (RR 0.81 95% CI 0.73, 0.90), iron supplementation 17% (RR 0.83 95% CI 0.75, 0.92) and I.V Ferric Carboxy-maltose 15% (RR 0.85 95% CI 0.74, 0.97) (I-squared = 0%). Interventions in African region had a higher (16%) and significant effect compared to other regions (fixed-effects model RR 0.84, 95% CI 0.79-0.89; P<.001) (X-squared 7;25=176.53, P<.00001;I-squared = 7%). Multiple center studies had a significant predictive effect (16%) compared to single center studies (fixed-effects model RR 0.84, 95% CI 0.79-0.89; P<.00001)(967;25=176.53, P<.00001; I-squared=97%) .The year 2020 recorded the highest effect of maternal anemia interventions at 28% (random-effects model RR 0.72, 95% CI 0.67-0.78; P<.00001) (967;23=167.34, P<.00001; I-squared =98%) Conclusion In the advent of COVID-19, maternal anemia interventions were compromised demonstrated by a low effectiveness trend from the year 2020 to the year 2022. During this period, even the most effective and recommended interventions against maternal anemia were somehow affected.
Keywords	covid19
Language	English
Publishing date	2024-02-20
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2024.02.18.24302492
Database	COVID19

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