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  1. Article ; Online: Choledochal cysts: part 1 of 3: classification and pathogenesis.

    Singham, Janakie / Yoshida, Eric M / Scudamore, Charles H

    Canadian journal of surgery. Journal canadien de chirurgie

    2009  Volume 52, Issue 5, Page(s) 434–440

    Abstract: ... describing the etiology, classification, pathogenesis and malignant potential of choledochal cysts. ... about this disease entity, and the purpose of this 3-part review is to organize the available literature and present ... the various theories currently argued by the experts. In part 1, we discuss the background of the disease ...

    Abstract Much about the etiology, pathophysiology, natural course and optimal treatment of cystic disease of the biliary tree remains under debate. Gastroenterologists, surgeons and radiologists alike still strive to optimize their roles in the management of choledochal cysts. To that end, much has been written about this disease entity, and the purpose of this 3-part review is to organize the available literature and present the various theories currently argued by the experts. In part 1, we discuss the background of the disease, describing the etiology, classification, pathogenesis and malignant potential of choledochal cysts.
    MeSH term(s) Bile Duct Neoplasms/epidemiology ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/surgery ; Cell Transformation, Neoplastic/pathology ; Cholangiopancreatography, Endoscopic Retrograde ; Choledochal Cyst/classification ; Choledochal Cyst/pathology ; Choledochal Cyst/surgery ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Precancerous Conditions/pathology ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome
    Language English
    Publishing date 2009-09-24
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 221: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Preliminary exploration of animal models of congenital choledochal cysts.

    Zhang, Shu-Hao / Zhang, Yue-Bin / Cai, Duo-Te / Pan, Tao / Chen, Ken / Jin, Yi / Luo, Wen-Juan / Huang, Zong-Wei / Chen, Qing-Jiang / Gao, Zhi-Gang

    World journal of gastroenterology

    2024  Volume 30, Issue 10, Page(s) 1420–1430

    Abstract: ... Results: Dilation classified as mild (diameter, ≥ 1 mm to < 3 mm), moderate (≥ 3 mm to < 10 mm), and ... transducer and activator of transcription 3 in rat model was consistent with the human CC tissues ... Background: Various animal models have been used to explore the pathogenesis of choledochal cysts ...

    Abstract Background: Various animal models have been used to explore the pathogenesis of choledochal cysts (CCs), but with little convincing results. Current surgical techniques can achieve satisfactory outcomes for treatment of CCs. Consequently, recent studies have focused more on clinical issues rather than basic research. Therefore, we need appropriate animal models to further basic research.
    Aim: To establish an appropriate animal model that may contribute to the investigation of the pathogenesis of CCs.
    Methods: Eighty-four specific pathogen-free female Sprague-Dawley rats were randomly allocated to a surgical group, sham surgical group, or control group. A rat model of CC was established by partial ligation of the bile duct. The reliability of the model was confirmed by measurements of serum biochemical indices, morphology of common bile ducts of the rats as well as molecular biology experiments in rat and human tissues.
    Results: Dilation classified as mild (diameter, ≥ 1 mm to < 3 mm), moderate (≥ 3 mm to < 10 mm), and severe (≥ 10 mm) was observed in 17, 17, and 2 rats in the surgical group, respectively, while no dilation was observed in the control and sham surgical groups. Serum levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, and total bile acids were significantly elevated in the surgical group as compared to the control group 7 d after surgery, while direct bilirubin, total bilirubin, and gamma-glutamyltransferase were further increased 14 d after surgery. Most of the biochemical indices gradually decreased to normal ranges 28 d after surgery. The protein expression trend of signal transducer and activator of transcription 3 in rat model was consistent with the human CC tissues.
    Conclusion: The model of partial ligation of the bile duct of juvenile rats could morphologically simulate the cystic or fusiform CC, which may contribute to investigating the pathogenesis of CC.
    MeSH term(s) Humans ; Female ; Rats ; Animals ; Choledochal Cyst/surgery ; Reproducibility of Results ; Rats, Sprague-Dawley ; Models, Animal ; Dilatation, Pathologic ; Bilirubin ; Disease Models, Animal
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i10.1420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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