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  1. Article ; Online: SARS-CoV-2 infection and COVID-19 in asthmatics: a complex relationship.

    Skevaki, Chrysanthi / Karsonova, Antonina / Karaulov, Alexander / Fomina, Daria / Xie, Min / Chinthrajah, Sharon / Nadeau, Kari C / Renz, Harald

    Nature reviews. Immunology

    2021  Volume 21, Issue 4, Page(s) 202–203

    MeSH term(s) Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Asthma/epidemiology ; Asthma/immunology ; COVID-19/epidemiology ; Eosinophilia/immunology ; Humans ; Interleukin-13/immunology ; Interleukin-4/immunology ; Interleukin-5/immunology ; Phenotype ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/immunology ; RNA, Messenger/metabolism ; Receptors, Coronavirus/genetics ; Receptors, Coronavirus/metabolism ; Risk ; SARS-CoV-2 ; Severity of Illness Index ; Th1 Cells/immunology ; Th17 Cells/immunology ; Th2 Cells/immunology
    Chemical Substances Interleukin-13 ; Interleukin-5 ; RNA, Messenger ; Receptors, Coronavirus ; Interleukin-4 (207137-56-2) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-021-00516-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Regulation of mRNA transcripts, protein isoforms, glycosylation and spatial localization of ACE2 and other SARS-CoV-2-associated molecules in human airway epithelium upon viral infection and type 2 inflammation

    Stocker, Nino / Radzikowska, Urszula / Wawrzyniak, Paulina / Tan, Ge / Huang, Mengting / Ding, Mei / Akdis, Cezmi / Sokolowska, Milena

    bioRxiv

    Abstract: ... or can constitute some forms of protection against COVID-19. ACE2 and other SARS-CoV-2-related host ... SARS-CoV-2 infection continues to pose a significant life threat, especially in patients ... proteins are limiting factors of an infection, expression of which is regulated in a more complex way ...

    Abstract SARS-CoV-2 infection continues to pose a significant life threat, especially in patients with comorbidities. It remains unknown, if asthma or allergen- and virus-induced airway inflammation are risk factors or can constitute some forms of protection against COVID-19. ACE2 and other SARS-CoV-2-related host proteins are limiting factors of an infection, expression of which is regulated in a more complex way than previously anticipated. Hence, we studied the expression of ACE2 mRNA and protein isoforms, together with its glycosylation and spatial localization in house dust mite (HDM)-, interleukin-13 (IL-13)- and human rhinovirus (RV)-induced inflammation in the primary human bronchial airway epithelium of healthy subjects and patients with asthma. IL-13 decreased the expression of long ACE2 mRNA and glycosylation of full-length ACE2 protein via alteration of the N-linked glycosylation process, limiting its availability on the apical side of ciliated cells. RV infection increased short ACE2 mRNA, but it did not influence its protein expression. HDM exposure did not affect ACE2 mRNA or protein. IL-13 and RV significantly regulated mRNA, but not protein expression of TMPRSS2 and NRP1. Regulation of ACE2 and other host proteins was similar in healthy and asthmatic epithelium, underlining the lack of intrinsic differences, but rather the dependence on the inflammatory milieu in the airways.
    Keywords covid19
    Language English
    Publishing date 2022-07-20
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2022.07.19.500631
    Database COVID19

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