Article ; Online: Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications.
2020 Volume 34, Issue 3 Suppl, Page(s) 1589–1592
Abstract: COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or ... signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger ... related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 ...
| Abstract | COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction appears to be associated with a cytokine storm related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger of pulmonary failure. This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy. |
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| MeSH term(s) | Anti-Inflammatory Agents/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19 ; Clinical Trials as Topic ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Cytokine Receptor gp130/antagonists & inhibitors ; Cytokine Receptor gp130/physiology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/physiopathology ; Humans ; Immunotherapy ; Indoles/therapeutic use ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/physiology ; Lung/pathology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/physiology ; Receptors, Virus/drug effects ; Signal Transduction |
| Chemical Substances | Anti-Inflammatory Agents ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antiviral Agents ; IL6 protein, human ; Indoles ; Interleukin-6 ; Receptors, Interleukin-6 ; Receptors, Virus ; Cytokine Receptor gp130 (133483-10-0) ; bazedoxifene (Q16TT9C5BK) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-06-05 |
| Publishing country | Greece |
| Document type | Journal Article ; Review |
| ZDB-ID | 807031-3 |
| ISSN | 1791-7549 ; 0258-851X |
| ISSN (online) | 1791-7549 |
| ISSN | 0258-851X |
| DOI | 10.21873/invivo.11947 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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