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  1. Article: Mycobactins: iron-chelating growth factors from mycobacteria.

    Snow, G A

    Bacteriological reviews

    1970  Volume 34, Issue 2, Page(s) 99–125

    MeSH term(s) Chemistry ; Growth Inhibitors ; Growth Substances/analysis ; Growth Substances/biosynthesis ; Growth Substances/history ; Growth Substances/isolation & purification ; Growth Substances/metabolism ; Growth Substances/pharmacology ; History, 20th Century ; Iron/metabolism ; Magnetic Resonance Spectroscopy ; Mycobacterium/analysis ; Mycobacterium/classification ; Mycobacterium/growth & development ; Mycobacterium/metabolism ; Species Specificity ; Spectrum Analysis
    Chemical Substances Growth Inhibitors ; Growth Substances ; Iron (E1UOL152H7)
    Language English
    Publishing date 1970-06
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 207943-4
    ISSN 0005-3678
    ISSN 0005-3678
    DOI 10.1128/br.34.2.99-125.1970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mycobacterium paratuberculosis. Factors that influence mycobactin dependence.

    Lambrecht, R S / Collins, M T

    Diagnostic microbiology and infectious disease

    1992  Volume 15, Issue 3, Page(s) 239–246

    Abstract: ... for optimal growth. In media without mycobactin at iron concentrations less than or equal to 100 microM ... growth of M. paratuberculosis occurred at pH 5.0, but not pH 6.8. Iron concentrations greater than 100 ... that is synthesized by most Mycobacterium spp. and necessary for the growth of all mycobacteria ...

    Abstract Mycobacterium paratuberculosis does not produce any detectable mycobactin, an iron-binding compound that is synthesized by most Mycobacterium spp. and necessary for the growth of all mycobacteria. This study examined the influence of various culture conditions on mycobactin dependence in M. paratuberculosis. Using a radiometric growth assay, we found the minimal concentration of mycobactin J necessary for growth of M. paratuberculosis to be 0.006 microM, whereas 1.2 microM (1 microgram/ml) was required for optimal growth. In media without mycobactin at iron concentrations less than or equal to 100 microM, growth of M. paratuberculosis occurred at pH 5.0, but not pH 6.8. Iron concentrations greater than 100 microM did not significantly increase growth at pH 5.0, but at pH 6.8 the growth rate increased with increasing amounts of iron reaching a rate equal to control cultures containing mycobactin. Mycobacterium paratuberculosis appeared to lose mycobactin dependence when subcultured; however, this was subsequently shown to be a result of mycobactin carried over from primary medium. Removal of this contaminating cell-wall-associated mycobactin reestablished mycobactin dependence. We conclude that mycobactin dependence must be carefully determined because it is a key test used in identification of M. paratuberculosis and may be easily influenced by media pH, iron concentration, and mycobactin carryover from primary media.
    MeSH term(s) Animals ; Cattle ; Culture Media ; Growth Substances/metabolism ; Hydrogen-Ion Concentration ; Iron/metabolism ; Iron Chelating Agents/metabolism ; Microscopy, Electron ; Mycobacterium avium subsp. paratuberculosis/growth & development ; Mycobacterium avium subsp. paratuberculosis/ultrastructure ; Oxazoles/metabolism
    Chemical Substances Culture Media ; Growth Substances ; Iron Chelating Agents ; Oxazoles ; mycobactins ; Iron (E1UOL152H7)
    Language English
    Publishing date 1992-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 0732-8893
    ISSN 0732-8893
    DOI 10.1016/0732-8893(92)90119-e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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