Article ; Online: Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.
2016 Volume 126, Page(s) 69–80
Abstract: ... properties of the antivirals saliphenylhalamide (SaliPhe), SNS-032, obatoclax, and gemcitabine, and found ... patients against co- and re-infections. To answer to this question, we analysed immuno-modulating ... of innate immune responses in lipopolysaccharide (LPS)- and interferon alpha (IFNα)-stimulated macrophages. Moreover, immuno ...
| Abstract | Influenza A viruses (IAVs) impact the public health and global economy by causing yearly epidemics and occasional pandemics. Several anti-IAV drugs are available and many are in development. However, the question remains which of these antiviral agents may allow activation of immune responses and protect patients against co- and re-infections. To answer to this question, we analysed immuno-modulating properties of the antivirals saliphenylhalamide (SaliPhe), SNS-032, obatoclax, and gemcitabine, and found that only gemcitabine did not impair immune responses in infected cells. It also allowed activation of innate immune responses in lipopolysaccharide (LPS)- and interferon alpha (IFNα)-stimulated macrophages. Moreover, immuno-mediators produced by gemcitabine-treated IAV-infected macrophages were able to prime immune responses in non-infected cells. Thus, we identified an antiviral agent which might be beneficial for treatment of patients with severe viral infections. |
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| MeSH term(s) | Amides/pharmacology ; Antineoplastic Agents/pharmacology ; Antiviral Agents/pharmacology ; Cells, Cultured ; Coinfection/drug therapy ; Coinfection/virology ; Cytokines/metabolism ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Humans ; Immunity, Innate/drug effects ; Immunologic Factors/pharmacology ; Influenza A virus/drug effects ; Influenza A virus/physiology ; Influenza, Human/drug therapy ; Influenza, Human/immunology ; Influenza, Human/virology ; Interferon-alpha/drug effects ; Interferon-alpha/immunology ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/virology ; Oxazoles/pharmacology ; Phosphoproteins/metabolism ; Pyrroles/pharmacology ; RNA, Viral/biosynthesis ; Salicylates/pharmacology ; Thiazoles/pharmacology ; Virus Replication/drug effects ; Virus Replication/physiology | |||||
| Chemical Substances | Amides ; Antineoplastic Agents ; Antiviral Agents ; Cytokines ; Immunologic Factors ; Interferon-alpha ; Lipopolysaccharides ; N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide ; Oxazoles ; Phosphoproteins ; Pyrroles ; RNA, Viral ; Salicylates ; Thiazoles ; saliphenylhalamide ; Deoxycytidine (0W860991D6) ; gemcitabine (B76N6SBZ8R) ; obatoclax (QN4128B52A) | |||||
| Language | English | |||||
| Publishing date | 2016-02 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 306628-9 | |||||
| ISSN | 1872-9096 ; 0166-3542 | |||||
| ISSN (online) | 1872-9096 | |||||
| ISSN | 0166-3542 | |||||
| DOI | 10.1016/j.antiviral.2015.12.011 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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