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  1. Article ; Online: COVID-19 infection and the kidneys: Learning the lesson.

    Soliman, Neveen A

    Journal of infection and public health

    2021  Volume 14, Issue 7, Page(s) 922–926

    Abstract: ... how kidneys are affected by COVID-19 infection, this review focuses on pathogenic and clinical links ... between COVID-19 infection and the kidneys. SARS-CoV-2 infected patients are target for kidney affection ... affection in COVID-19, kidneys continue to be deleteriously affected particularly in critical care settings ...

    Abstract The novel coronavirus 2019 pandemic has become a global health crisis. In an attempt to decipher how kidneys are affected by COVID-19 infection, this review focuses on pathogenic and clinical links between COVID-19 infection and the kidneys. SARS-CoV-2 infected patients are target for kidney affection, renal tropism, among other multiorgan complications. COVID-19 related kidney affection is reported not only in infected chronic kidney disease patients but also in those with no prior history of kidney disease. As nephrologists try to keep up with the rapidly evolving, sometimes hasty, reports on renal affection in COVID-19, kidneys continue to be deleteriously affected particularly in critical care settings. This review aims to briefly portray renal involvement in COVID-19 amid this unprecedented deluge of scientific data. Based on gained knowledge and expertise, it is prudent to develop and regularly update preventive, diagnostic and therapeutic strategies to improve clinical outcome and reduce mortality.
    MeSH term(s) COVID-19 ; Humans ; Kidney ; Pandemics ; Renal Insufficiency, Chronic ; SARS-CoV-2
    Language English
    Publishing date 2021-05-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2467587-8
    ISSN 1876-035X ; 1876-0341
    ISSN (online) 1876-035X
    ISSN 1876-0341
    DOI 10.1016/j.jiph.2021.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Multi-omics Approach in Kidney Transplant: Lessons Learned from COVID-19 Pandemic.

    Mizuno, Hiroki / Murakami, Naoka

    Current transplantation reports

    2023  Volume 10, Issue 4, Page(s) 173–187

    Abstract: ... in kidney transplant and COVID-19. Herein, we discuss updated findings of multi-omics data on kidney ... transplant outcomes, as well as COVID-19 and kidney transplant.: Recent findings: Transcriptomics, proteomics, and ... COVID-19. Although multi-omics data on kidney transplant and COVID-19 is limited, activation of innate ...

    Abstract Purpose of review: Multi-omics approach has advanced our knowledge on transplantation-associated clinical outcomes, such as acute rejection and infection, and emerging omics data are becoming available in kidney transplant and COVID-19. Herein, we discuss updated findings of multi-omics data on kidney transplant outcomes, as well as COVID-19 and kidney transplant.
    Recent findings: Transcriptomics, proteomics, and metabolomics revealed various inflammation pathways associated with kidney transplantation-related outcomes and COVID-19. Although multi-omics data on kidney transplant and COVID-19 is limited, activation of innate immune pathways and suppression of adaptive immune pathways were observed in the active phase of COVID-19 in kidney transplant recipients.
    Summary: Multi-omics analysis has led us to a deeper exploration and a more comprehensive understanding of key biological pathways in complex clinical settings, such as kidney transplantation and COVID-19. Future multi-omics analysis leveraging multi-center biobank collaborative will further advance our knowledge on the precise immunological responses to allograft and emerging pathogens.
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2196-3029
    ISSN 2196-3029
    DOI 10.1007/s40472-023-00410-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lessons Learned from Cross-Systems Approach to COVID-19 Pandemic Response in Juvenile Justice System, Colorado, USA.

    Tunstall, Ashley M / O'Brien, Shannon C / Monaghan, Deborah M / Burakoff, Alexis / Marquardt, Renée K

    Emerging infectious diseases

    2024  Volume 30, Issue 13, Page(s) S13–S16

    Abstract: ... lessons learned and offer recommendations on pandemic emergency response planning and managing a statewide ... The global COVID-19 pandemic illustrates the importance of a close partnership between ... must balance the risk for disease against the negative effects of restrictions. Key aspects of the COVID-19 ...

    Abstract The global COVID-19 pandemic illustrates the importance of a close partnership between public health and juvenile justice systems when responding to communicable diseases. Many setting-specific obstacles must be navigated to respond effectively to limit disease transmission and negative health outcomes while maintaining necessary services for youth in confinement facilities. The response requires multidisciplinary expertise and collaboration to address unique considerations. Public health mitigation strategies must balance the risk for disease against the negative effects of restrictions. Key aspects of the COVID-19 response in the juvenile justice system of Colorado, USA, involved establishing robust communication and data reporting infrastructures, building a multidisciplinary response team, adapting existing infection prevention guidelines, and focusing on a whole-person health approach to infection prevention. We examine lessons learned and offer recommendations on pandemic emergency response planning and managing a statewide public health emergency in youth confinement settings that ensure ongoing readiness.
    MeSH term(s) Adolescent ; Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics/prevention & control ; Colorado/epidemiology ; Public Health ; Systems Analysis
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid3013.230782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 infection and the kidneys

    Neveen A. Soliman

    Journal of Infection and Public Health, Vol 14, Iss 7, Pp 922-

    Learning the lesson

    2021  Volume 926

    Abstract: ... how kidneys are affected by COVID-19 infection, this review focuses on pathogenic and clinical links ... between COVID-19 infection and the kidneys. SARS-CoV-2 infected patients are target for kidney affection ... affection in COVID-19, kidneys continue to be deleteriously affected particularly in critical care settings ...

    Abstract The novel coronavirus 2019 pandemic has become a global health crisis. In an attempt to decipher how kidneys are affected by COVID-19 infection, this review focuses on pathogenic and clinical links between COVID-19 infection and the kidneys. SARS-CoV-2 infected patients are target for kidney affection, renal tropism, among other multiorgan complications. COVID-19 related kidney affection is reported not only in infected chronic kidney disease patients but also in those with no prior history of kidney disease. As nephrologists try to keep up with the rapidly evolving, sometimes hasty, reports on renal affection in COVID-19, kidneys continue to be deleteriously affected particularly in critical care settings. This review aims to briefly portray renal involvement in COVID-19 amid this unprecedented deluge of scientific data. Based on gained knowledge and expertise, it is prudent to develop and regularly update preventive, diagnostic and therapeutic strategies to improve clinical outcome and reduce mortality.
    Keywords SARS-CoV-2 ; pathogenesis ; Acute kidney injury ; Dialysis ; Transplantation ; Diagnosis ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 616
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Deaths by COVID-19 in a hospital from a city from Legal Amazon region

    Fabrício Silva Pessoa / Helena Beatriz Moura Martins / Agostinha Pereira Rocha Neta / Andinilde Nogueira Martins / Francisca Bruna / Adriana Sousa Rêgo / Givago da Silva Souza / Luís Cláudio Nascimento da Silva / Maria Rosa Quaresma Bomfim / Eliza Maria da Costa Brito Lacerda

    Medicina, Vol 56, Iss

    what lessons could be learned?

    2023  Volume 1

    Abstract: Objectives: Describe the epidemiology of COVID-19 deaths within a hospital in the Amazon region ... in a period of 64 days, which corresponds to the growth curve of the COVID-19 first-wave pandemic in 2020 ... associated comorbidities such as arterial hypertension, diabetes mellitus, and kidney disease. The SARS-CoV-2 ...

    Abstract Objectives: Describe the epidemiology of COVID-19 deaths within a hospital in the Amazon region in a period of 64 days, which corresponds to the growth curve of the COVID-19 first-wave pandemic in 2020. Methods: The data were obtained from medical records of 152 deaths registered for adults and elderly hospitalized. The data were also compared with the number of deaths in previous years during the same period studied to assess the impact of the pandemic on this hospital. The study also assesses the impact of intra-hospital transfers, accounting for the number of times patients who died performed transfers between sectors of the hospital. Results: During the period analyzed, there was an increase in deaths compared to the previous years. The majority of dead patients were male, aged between 34 and 96 years. The deaths were associated comorbidities such as arterial hypertension, diabetes mellitus, and kidney disease. The SARS-CoV-2 infection was confirmed in 91 cases. Among them, 15 individuals were admitted without conditions related to SARS-CoV-2 infection; they had a three-fold higher number of hospital transfers than those admitted with SARS-CoV-2 infection symptoms. Sixteen patients with SARS-CoV-2 infection developed respiratory symptoms just after hospitalization. The diagnostic exam for SARS-CoV-2 infection was performed on average 4 (± 6) days after the onset of symptoms and 6 (± 6) days after admission, and the average time from the onset of respiratory symptoms to death was 4 (± 6) days. Conclusions: These data suggest the high presence of hospital infection by SARS-CoV-2 in the Brazilian Amazon region, which may be related to the number of sectorial transfers, delay in confirming the diagnosis, and lack of management. We report a serious public health problem, as it demonstrates the fragility of healthcare institutions in the hospital environment.
    Keywords COVID-19 ; SARS-CoV-2 ; 2019 novel coronavirus Pandemic ; Nosocomial infection ; Amazon region ; Medicine ; R
    Subject code 360
    Language Portuguese
    Publishing date 2023-04-01T00:00:00Z
    Publisher Universidade de São Paulo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Engaging diverse populations in aging research during the COVID-19 pandemic

    Irving E. Vega / Kristine J. Ajrouch / Vanessa Rorai / Renee Gadwa / J. Scott Roberts / Linda Nyquist

    Frontiers in Public Health, Vol

    Lessons learned from four National Institutes of Health funded-Centers

    2023  Volume 11

    Abstract: BackgroundThe COVID-19 pandemic’s impact on our personal and professional lives required a rapid ... community partnerships. To address the social and research challenges evolving from the COVID-19 pandemic ... vaccination and understanding of the effect of COVID-19 to the brain. Different strategies were used ...

    Abstract BackgroundThe COVID-19 pandemic’s impact on our personal and professional lives required a rapid adaptation to the evolving health crisis and accumulating social stresses. Established measures to reduce the spread of infection and potential death had a direct effect on ongoing research that involved older adults and underrepresented racial/ethnic groups. Although important to preserve public health, these measures risk further isolation of vulnerable research participant populations and threatened established community partnerships. To address the social and research challenges evolving from the COVID-19 pandemic, four National Institutes of Health funded-Centers that engage with community members to enhance research and advance the science of aging came together to learn from each other’s efforts, approaches, and communication with community partners.MethodsMonthly meetings served as a venue to discuss the challenges of engagement with research participants and support community partners during the pandemic. The developed learning community also contributed to recognize and address research staff stress and isolation. We describe how these conversations led our Centers to address unprecedented challenges and sustain community engagement within diverse populations, especially Black/African Americans, Latinos, Middle Eastern/Arab Americans and the oldest-old.ResultsThe exchange of information resulted in maintaining long standing community relationships and partnerships in the face of the uncertainties generated by the pandemic. The strategies included adapting education programs to reduce risk of infection, recognizing symptoms, promoting vaccination and understanding of the effect of COVID-19 to the brain. Different strategies were used to address the effects of isolation and maintain community engagement. Although new research participant enrollment was a challenge, telephone and virtual visits allowed research participants to remain active in research. Community members participation in virtual learning ...
    Keywords aging ; community engagement ; underrepresented groups ; COVID-19 ; centers and institutes ; Public aspects of medicine ; RA1-1270
    Subject code 306
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Practicing With Uncertainty: Kidney Transplantation During the COVID-19 Pandemic.

    Lentine, Krista L / Mannon, Roslyn B / Josephson, Michelle A

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2021  Volume 77, Issue 5, Page(s) 777–785

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic required transplant nephrologists, surgeons, and ... to the pandemic and consider lessons learned, including those related to the risks, benefits, and logistical ... for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their use in transplant recipients, current consensus ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic required transplant nephrologists, surgeons, and care teams to make decisions about the full spectrum of transplant program operations and clinical practices in the absence of experience or data. Initially, across the country, there was a reduction in kidney transplant procedures and a striking pause in the conduct of living donation and living-donor transplant surgeries. Aspects of candidate evaluation and follow-up rapidly converted to telehealth. Months into the pandemic, much has been learned from experiences worldwide, yet many questions remain. In this Perspective, we reflect on some of the practice decisions made by the transplant community in the initial response to the pandemic and consider lessons learned, including those related to the risks, benefits, and logistical considerations of proceeding with versus delaying deceased-donor transplantation, living donation, and living-donor transplantation during the pandemic. We review the evolution of therapeutic strategies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their use in transplant recipients, current consensus related to immunosuppression management in infected transplant recipients, and emerging information on vaccination against SARS-CoV-2. We share our thoughts on research priorities, discuss the areas in which we are still practicing with uncertainty, and look ahead to the next phase of the pandemic response.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Clinical Decision-Making ; Critical Pathways/organization & administration ; Critical Pathways/trends ; Humans ; Immunosuppression/methods ; Infection Control/methods ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/methods ; SARS-CoV-2 ; Telemedicine/methods ; Time-to-Treatment ; Tissue Donors/statistics & numerical data ; Transplant Recipients
    Language English
    Publishing date 2021-01-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2020.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Engaging diverse populations in aging research during the COVID-19 pandemic: Lessons learned from four National Institutes of Health funded-Centers.

    Vega, Irving E / Ajrouch, Kristine J / Rorai, Vanessa / Gadwa, Renee / Roberts, J Scott / Nyquist, Linda

    Frontiers in public health

    2023  Volume 11, Page(s) 1062385

    Abstract: Background: The COVID-19 pandemic's impact on our personal and professional lives required a rapid ... community partnerships. To address the social and research challenges evolving from the COVID-19 pandemic ... vaccination and understanding of the effect of COVID-19 to the brain. Different strategies were used ...

    Abstract Background: The COVID-19 pandemic's impact on our personal and professional lives required a rapid adaptation to the evolving health crisis and accumulating social stresses. Established measures to reduce the spread of infection and potential death had a direct effect on ongoing research that involved older adults and underrepresented racial/ethnic groups. Although important to preserve public health, these measures risk further isolation of vulnerable research participant populations and threatened established community partnerships. To address the social and research challenges evolving from the COVID-19 pandemic, four National Institutes of Health funded-Centers that engage with community members to enhance research and advance the science of aging came together to learn from each other's efforts, approaches, and communication with community partners.
    Methods: Monthly meetings served as a venue to discuss the challenges of engagement with research participants and support community partners during the pandemic. The developed learning community also contributed to recognize and address research staff stress and isolation. We describe how these conversations led our Centers to address unprecedented challenges and sustain community engagement within diverse populations, especially Black/African Americans, Latinos, Middle Eastern/Arab Americans and the oldest-old.
    Results: The exchange of information resulted in maintaining long standing community relationships and partnerships in the face of the uncertainties generated by the pandemic. The strategies included adapting education programs to reduce risk of infection, recognizing symptoms, promoting vaccination and understanding of the effect of COVID-19 to the brain. Different strategies were used to address the effects of isolation and maintain community engagement. Although new research participant enrollment was a challenge, telephone and virtual visits allowed research participants to remain active in research. Community members participation in virtual learning events was variable, ranging from a dozen to hundreds of participants. Invitations to organize panels about newly developed topics indicated the need for information from trusted sources.
    Conclusion: In sum, the COVID-19 pandemic re - directed all four Centers' commitment to community service led to developing strategies for social support, which will potentially contribute to transforming public perceptions about research and researchers.
    MeSH term(s) Humans ; United States/epidemiology ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Pandemics ; Geroscience ; Community Participation/methods ; National Institutes of Health (U.S.)
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1062385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: How positive deviants helped in fighting the early phase of COVID-19 pandemic? A qualitative study exploring the roles of frontline health workers in Nepal.

    Dhital, Rolina / Subedi, Madhusudan / Hamal, Pawan Kumar / Shrestha, Carmina / Bhusal, Sandesh / Rimal, Reshika / Gopali, Lovin / Shah, Richa

    PLOS global public health

    2023  Volume 3, Issue 3, Page(s) e0000671

    Abstract: ... able to reflect upon the positive lessons learned, such as self-sustainability, teamwork, and policy ... to study frontline workers in the context of COVID-19. Therefore, this study aimed to explore the positive ... deviance traits among frontline health workers during the early days of the COVID-19 pandemic in Nepal ...

    Abstract Positive deviance is an approach wherein learnings from persons who fare better than their peers under similar circumstances are used to enable behavioral and social change. Such behaviors and solutions are likely affordable, acceptable, sustainable, and fit into the socio-cultural milieu. Despite the wide use of positive deviance in many public health programs and research, it has yet to be used to study frontline workers in the context of COVID-19. Therefore, this study aimed to explore the positive deviance traits among frontline health workers during the early days of the COVID-19 pandemic in Nepal. This qualitative study followed a grounded theory approach. The data was collected through in-depth interviews among the 17 identified participants representing different cadres of the health workforce, types of health facilities, and regions across Nepal purposively. The findings are structured around four major themes: challenges, finding solutions and innovations, positive lessons, and motivations. The personal challenges included fear and anxiety about the uncertainties. The professional challenges included stigma, infection control, and changing work style with the use of personal protective equipment. Despite the challenges, they managed available resources and innovated low-cost, technological, and practice-based solutions. They were able to reflect upon the positive lessons learned, such as self-sustainability, teamwork, and policy direction and research, and self-reflection of personal growth and patient care. The intrinsic motivation included their inherent value system, and the extrinsic motivation included appreciation and acknowledgment, family and social support, psychosocial support from peers, and support from higher authorities. This study provides insights into how the positive deviance approach can help identify the solution amid the most challenging circumstances, such as the COVID-19 pandemic in low-resource settings. However, more extensive studies are warranted to explore deeper into positive deviance and its long-term effects in bringing positive outcomes during the pandemic.
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0000671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions.

    Geetha, Duvuru / Kronbichler, Andreas / Rutter, Megan / Bajpai, Divya / Menez, Steven / Weissenbacher, Annemarie / Anand, Shuchi / Lin, Eugene / Carlson, Nicholas / Sozio, Stephen / Fowler, Kevin / Bignall, Ray / Ducharlet, Kathryn / Tannor, Elliot K / Wijewickrama, Eranga / Hafidz, Muhammad I A / Tesar, Vladimir / Hoover, Robert / Crews, Deidra /
    Varnell, Charles / Danziger-Isakov, Lara / Jha, Vivekanand / Mohan, Sumit / Parikh, Chirag / Luyckx, Valerie

    Nature reviews. Nephrology

    2022  Volume 18, Issue 11, Page(s) 724–737

    Abstract: ... For patients, increased infection risk and disease severity, often complicated by acute kidney injury, have ... support of patients with kidney disease, infection mitigation strategies, resource allocation and support ... The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected patients ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected patients with kidney disease, causing significant challenges in disease management, kidney research and trainee education. For patients, increased infection risk and disease severity, often complicated by acute kidney injury, have contributed to high mortality. Clinicians were faced with high clinical demands, resource shortages and novel ethical dilemmas in providing patient care. In this review, we address the impact of COVID-19 on the entire spectrum of kidney care, including acute kidney injury, chronic kidney disease, dialysis and transplantation, trainee education, disparities in health care, changes in health care policies, moral distress and the patient perspective. Based on current evidence, we provide a framework for the management and support of patients with kidney disease, infection mitigation strategies, resource allocation and support systems for the nephrology workforce.
    MeSH term(s) Humans ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Renal Dialysis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/therapy ; Kidney
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00618-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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