Article ; Online: Massive mobilization of dendritic cells during influenza A virus subtype H5N1 infection of nonhuman primates.
The Journal of infectious diseases
2014 Volume 209, Issue 12, Page(s) 2012–2016
Abstract: ... response, but the impact of infection on dendritic cells (DCs) is unknown. We show that influenza A virus ... Highly pathogenic avian influenza virus infection is characterized by a marked inflammatory ... subtype H5N1 infection rapidly and profoundly impacts DCs in cynomolgus macaques, increasing the number ...
| Abstract | Highly pathogenic avian influenza virus infection is characterized by a marked inflammatory response, but the impact of infection on dendritic cells (DCs) is unknown. We show that influenza A virus subtype H5N1 infection rapidly and profoundly impacts DCs in cynomolgus macaques, increasing the number of blood myeloid and plasmacytoid DCs by 16- and 60-fold, respectively. Infection was associated with recruitment, activation, and apoptosis of DCs in lung-draining lymph nodes; granulocyte and macrophage infiltration in lungs was also detected, together with expression of CXCL10. This degree of DC mobilization is unprecedented in viral infection and suggests a potential role for DCs in the pathogenesis of highly pathogenic avian influenza virus. |
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| MeSH term(s) | Animals ; Cell Proliferation ; Chemokine CXCL10/genetics ; Chemokine CXCL10/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/virology ; Influenza A Virus, H5N1 Subtype ; Lung/pathology ; Lung/virology ; Lymph Nodes/virology ; Macaca fascicularis/virology ; Macrophages/metabolism ; Male ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/pathology | ||||||||||
| Chemical Substances | Chemokine CXCL10 | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2014-01-07 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural | ||||||||||
| ZDB-ID | 3019-3 | ||||||||||
| ISSN | 1537-6613 ; 0022-1899 | ||||||||||
| ISSN (online) | 1537-6613 | ||||||||||
| ISSN | 0022-1899 | ||||||||||
| DOI | 10.1093/infdis/jiu009 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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