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  1. Article ; Online: Pathogenic Virus Detection by Optical Nanobiosensors.

    Song, Menglin / Yang, Mo / Hao, Jianhua

    Cell reports. Physical science

    2021  Volume 2, Issue 1, Page(s) 100288

    Abstract: ... biosensors based on nanotechnology for pathogenic virus detection is provided, with focus on quantum dots ... Among various nanoplatforms, optical nanobiosensors have aroused much interest due to their inherent advantages ... pathogenic viruses are developed. Nanotechnology-based biosensors are finding many applications in biological ...

    Abstract The novel coronavirus pandemic is sweeping the world and causing global crises. The lack of effective methods of early diagnosis and accurate detection may result in severe infection as well as mortality. Therefore, it is urgently required that rapid, selective, and accurate techniques for detecting pathogenic viruses are developed. Nanotechnology-based biosensors are finding many applications in biological detection, which may address these issues and realize direct detection of molecular targets in real time. Among various nanoplatforms, optical nanobiosensors have aroused much interest due to their inherent advantages of high sensitivity and direct readout. In this review, a summary of recent progress on the optical biosensors based on nanotechnology for pathogenic virus detection is provided, with focus on quantum dots (QDs), upconversion nanoparticles (UCNPs), noble metal nanoparticles, and organic fluorescent molecules-based nanoprobes and chemiluminescence assays. These representative studies demonstrate appealing performance as biosensors and hold great promise for clinical diagnosis.
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-3864
    ISSN (online) 2666-3864
    DOI 10.1016/j.xcrp.2020.100288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: AuNP-based biosensors for the diagnosis of pathogenic human coronaviruses: COVID-19 pandemic developments.

    Farzin, Mohammad Ali / Abdoos, Hassan / Saber, Reza

    Analytical and bioanalytical chemistry

    2022  Volume 414, Issue 24, Page(s) 7069–7084

    Abstract: ... alarmingly. Early detection of these viruses allows treatment interventions to be provided more quickly ... trends in the SARS-CoV-2 nanobiosensors from the beginning of the COVID-19 epidemic until 2022. We hope ... to deal with the spread of these deadly viruses. Currently, the nanomaterial-based sensing devices ...

    Abstract The outbreak rate of human coronaviruses (CoVs) especially highly pathogenic CoVs is increasing alarmingly. Early detection of these viruses allows treatment interventions to be provided more quickly to people at higher risk, as well as helping to identify asymptomatic carriers and isolate them as quickly as possible, thus preventing the disease transmission chain. The current diagnostic methods such as RT-PCR are not ideal due to high cost, low accuracy, low speed, and probability of false results. Therefore, a reliable and accurate method for the detection of CoVs in biofluids can become a front-line tool in order to deal with the spread of these deadly viruses. Currently, the nanomaterial-based sensing devices for detection of human coronaviruses from laboratory diagnosis to point-of-care (PoC) diagnosis are progressing rapidly. Gold nanoparticles (AuNPs) have revolutionized the field of biosensors because of the outstanding optical and electrochemical properties. In this review paper, a detailed overview of AuNP-based biosensing strategies with the varied transducers (electrochemical, optical, etc.) and also different biomarkers (protein antigens and nucleic acids) was presented for the detection of human coronaviruses including SARS-CoV-2, SARS-CoV-1, and MERS-CoV and lowly pathogenic CoVs. The present review highlights the newest trends in the SARS-CoV-2 nanobiosensors from the beginning of the COVID-19 epidemic until 2022. We hope that the presented examples in this review paper convince readers that AuNPs are a suitable platform for the designing of biosensors.
    MeSH term(s) Biosensing Techniques ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Gold ; Humans ; Metal Nanoparticles ; Nucleic Acids ; Pandemics ; SARS-CoV-2
    Chemical Substances Nucleic Acids ; Gold (7440-57-5)
    Language English
    Publishing date 2022-07-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-022-04193-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: AuNP-based biosensors for the diagnosis of pathogenic human coronaviruses: COVID-19 pandemic developments

    Farzin, Mohammad Ali / Abdoos, Hassan / Saber, Reza

    Analytical and bioanalytical chemistry. 2022 Oct., v. 414, no. 24

    2022  

    Abstract: ... alarmingly. Early detection of these viruses allows treatment interventions to be provided more quickly ... trends in the SARS-CoV-2 nanobiosensors from the beginning of the COVID-19 epidemic until 2022. We hope ... to deal with the spread of these deadly viruses. Currently, the nanomaterial-based sensing devices ...

    Abstract The outbreak rate of human coronaviruses (CoVs) especially highly pathogenic CoVs is increasing alarmingly. Early detection of these viruses allows treatment interventions to be provided more quickly to people at higher risk, as well as helping to identify asymptomatic carriers and isolate them as quickly as possible, thus preventing the disease transmission chain. The current diagnostic methods such as RT-PCR are not ideal due to high cost, low accuracy, low speed, and probability of false results. Therefore, a reliable and accurate method for the detection of CoVs in biofluids can become a front-line tool in order to deal with the spread of these deadly viruses. Currently, the nanomaterial-based sensing devices for detection of human coronaviruses from laboratory diagnosis to point-of-care (PoC) diagnosis are progressing rapidly. Gold nanoparticles (AuNPs) have revolutionized the field of biosensors because of the outstanding optical and electrochemical properties. In this review paper, a detailed overview of AuNP-based biosensing strategies with the varied transducers (electrochemical, optical, etc.) and also different biomarkers (protein antigens and nucleic acids) was presented for the detection of human coronaviruses including SARS-CoV-2, SARS-CoV-1, and MERS-CoV and lowly pathogenic CoVs. The present review highlights the newest trends in the SARS-CoV-2 nanobiosensors from the beginning of the COVID-19 epidemic until 2022. We hope that the presented examples in this review paper convince readers that AuNPs are a suitable platform for the designing of biosensors.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus ; Severe acute respiratory syndrome coronavirus 2 ; analytical chemistry ; biomarkers ; biosensors ; disease transmission ; electrochemistry ; humans ; laboratory diagnosis ; nanogold ; people ; point-of-care systems ; risk
    Language English
    Dates of publication 2022-10
    Size p. 7069-7084.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ISSN 1618-2642
    DOI 10.1007/s00216-022-04193-2
    Database NAL-Catalogue (AGRICOLA)

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