Article: Solute carrier transporters: the metabolic gatekeepers of immune cells.
Acta pharmaceutica Sinica. B
2019 Volume 10, Issue 1, Page(s) 61–78
Abstract: Solute carrier (SLC) transporters meditate many essential physiological functions, including ... on the roles of solute carrier transporters, which were discovered to regulate lymphocyte signaling and control ... amino-acid transporters, and metal ion transporters, which are critically important for mediating immune cell homeostasis ...
| Abstract | Solute carrier (SLC) transporters meditate many essential physiological functions, including nutrient uptake, ion influx/efflux, and waste disposal. In its protective role against tumors and infections, the mammalian immune system coordinates complex signals to support the proliferation, differentiation, and effector function of individual cell subsets. Recent research in this area has yielded surprising findings on the roles of solute carrier transporters, which were discovered to regulate lymphocyte signaling and control their differentiation, function, and fate by modulating diverse metabolic pathways and balanced levels of different metabolites. In this review, we present current information mainly on glucose transporters, amino-acid transporters, and metal ion transporters, which are critically important for mediating immune cell homeostasis in many different pathological conditions. |
|---|---|
| Language | English |
| Publishing date | 2019-12-14 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Review |
| ISSN | 2211-3835 |
| ISSN | 2211-3835 |
| DOI | 10.1016/j.apsb.2019.12.006 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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