Article ; Online: METTL3 regulates WTAP protein homeostasis.
2018 Volume 9, Issue 8, Page(s) 796
Abstract: The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including ... processing and cell proliferation. In addition, WTAP is also a regulator of the nuclear complex required ... acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA ...
| Abstract | The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation. In addition, WTAP is also a regulator of the nuclear complex required for the deposition of N |
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| MeSH term(s) | Cell Line, Tumor ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Methyltransferases/antagonists & inhibitors ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Proteostasis ; RNA Interference ; RNA, Small Interfering/metabolism ; Ribosomes/metabolism |
| Chemical Substances | Nuclear Proteins ; RNA, Small Interfering ; WTAP protein, human ; METTL14 protein, human (EC 2.1.1.-) ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) |
| Language | English |
| Publishing date | 2018-07-23 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2541626-1 |
| ISSN | 2041-4889 ; 2041-4889 |
| ISSN (online) | 2041-4889 |
| ISSN | 2041-4889 |
| DOI | 10.1038/s41419-018-0843-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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