Article: Nonspecific protection of mice against influenza virus infection by local or systemic immunization with Bacille Calmette-Guérin.
The Journal of infectious diseases
1977 Volume 136, Issue 2, Page(s) 171–175
Abstract: ... effectiveness of nonspecific immune stimulation with BCG on influenza virus infection in mice. Immunization ... with BCG resulted in significant protection of mice. Also, the local (nasal) route of immunization was more ... Bacille Calmette-Guérin (BCG) has been used effectively to protect nonspecifically against ...
| Abstract | Bacille Calmette-Guérin (BCG) has been used effectively to protect nonspecifically against bacterial infections and neoplasms, probably by enhancement of cell-mediated immunity. It has been suggested that cell-mediated immunity plays a role in the host defense against certain viral infections. In recent in vitro studies, macrophages from animals sensitized by BCG were more effective in lowering the titer of influenza virus than were macrophages from control animals. The purpose of this study was to investigate the in vivo effectiveness of nonspecific immune stimulation with BCG on influenza virus infection in mice. Immunization with BCG resulted in significant protection of mice. Also, the local (nasal) route of immunization was more effective than the systemic (intraperitoneal) route against the intranasal inoculum of virus, a finding which suggests that important role of local immunity, i.e., either earlier stimulation of secretory antibody or nonspecific cell-mediated immunity. The time course of the resistance ot infection suggests that interferon was not the protective mechanism. |
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| MeSH term(s) | Administration, Intranasal ; Animals ; BCG Vaccine/administration & dosage ; Female ; Immunization, Secondary ; Injections, Intraperitoneal ; Mice ; Orthomyxoviridae Infections/prevention & control ; Time Factors ; Vaccination | ||||||||||
| Chemical Substances | BCG Vaccine | ||||||||||
| Language | English | ||||||||||
| Publishing date | 1977-08 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, U.S. Gov't, P.H.S. | ||||||||||
| ZDB-ID | 3019-3 | ||||||||||
| ISSN | 1537-6613 ; 0022-1899 | ||||||||||
| ISSN (online) | 1537-6613 | ||||||||||
| ISSN | 0022-1899 | ||||||||||
| DOI | 10.1093/infdis/136.2.171 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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